Advancing Child Health Through Cellular and Molecular Biology

项目摘要/摘要 密歇根大学儿童健康研究职业发展奖(CHRCDA)计划 旨在支持初级儿科调查人员的职业发展。CHRCDA学者参与 在细胞和分子生物学方面的强化的、有指导的培训计划以及教学教育 旨在确保他们继续研究发展的计划。自1992年推出以来，密歇根 CHRCDA为近50名儿科科学家的培训做出了贡献，其中大多数人 获得了NIH儿童疾病研究的R级资金。这项续期申请的目的是： 1)招募最有前途的初级儿科医生--科学家进行培训，包括来自 不同的背景。为了扩大我们儿科医生-科学家的范围、覆盖面和多样性 现在，我们计划与密歇根儿童医院开展地区性合作。 底特律韦恩州立大学医学院附属机构。 2)加强儿科科研人员的转化性研究培训。这对学者来说是至关重要的 参与将医生、科学家、统计学家、专利专家聚集在一起的翻译研究团队 专家，还有更多。为了实现这一目标，我们计划利用密歇根研究所的资源 临床和健康研究(MICHR，密歇根大学CTSA总部)，以及 3)认识到许多儿科疾病在未得到充分服务的人群中更为常见， 部分原因是饮食和环境暴露。儿童肥胖与铅和其他物质的暴露 环境毒素是密歇根州儿童疾病的重要因素。为了满足这一需求，我们 计划进一步将我们的导师基础从密歇根大学儿科扩大到其他 系和学院，包括密歇根大学公共卫生学院和韦恩州立大学 大学环境健康科学研究所。 为了实现这些目标，项目主任奥皮帕里博士和联合培训主任赫申森博士 和利普舒尔茨，将得到1)科学咨询委员会的协助，以监督项目指导和学者 遴选和评估；2)外部咨询委员会，对方案进行独立审查；3) 一个监督学者教学培训的教育核心；4)两个招聘干事协助识别 和招聘少数族裔候选人；以及5)国家计划审查员，他们将被邀请到校园 对该计划进行年度审查，并评估UM CHRCDA学者项目的进展情况。 最后，由于迫切需要培养儿科医生和科学家，密歇根大学医学院 院长办公室和儿科和传染病系已同意提供配对 在该奖项的五年任期内，每年增加一名奖学金获得者。

Project Summary / Abstract The University of Michigan Child Health Research Career Development Award (CHRCDA) program is designed to support the career development of junior pediatric investigators. CHRCDA scholars participate in an intensive, mentored training program in cell and molecular biology as well as a didactic educational program designed to ensure their continued research development. Since its launch in 1992, the Michigan CHRCDA has contributed to the training of nearly 50 pediatrician-scientists, the majority of whom have obtained R-level NIH funding for the study of childhood diseases. The Aims of this renewal application are to: 1) Recruit the most promising junior pediatrician-scientists for training, including those from diverse backgrounds. In order to broaden the scope, reach and diversity of our pediatrician-scientist “pipeline,” we now plan to undertake a regional collaboration with the Children's Hospital of Michigan, an affiliate of Wayne State University School of Medicine in Detroit. 2) Enhance the translational research training of pediatrician-scientists. It is essential for scholars to participate in translational research teams bringing together physicians, bench scientists, statisticians, patent experts, and more. To accomplish this goal, we plan to leverage the resources of the Michigan Institute for Clinical and Health Research (MICHR, home of the University of Michigan CTSA), and 3) Recognize that many pediatric diseases are more common in underserved populations and arise in part from dietary and environmental exposures. Childhood obesity and exposure to lead and other environmental toxins are important contributors to disease in Michigan children. To address this need, we plan to further extend our mentor base from the University of Michigan Department of Pediatrics to other Departments and Schools, including the University of Michigan School of Public Health and the Wayne State University Institute of Environmental Health Sciences. To achieve these Aims, the Program Director, Dr. Opipari, and Co-Training Directors, Drs. Hershenson and Lipshultz, will be assisted by 1) a Scientific Advisory Committee to oversee program direction and scholar selection and evaluation; 2) an External Advisory Board to provide an independent review of the program; 3) an Education Core to oversee scholar didactic training; 4) two Recruitment Officers to assist in identification and recruitment of minority candidates; and 5) National Program Reviewers who will be invited to campus to perform an annual review of the program and assess the progress of the UM CHRCDA Scholars. Finally, due to the urgent need to train pediatrician-scientists, the University of Michigan Medical School Dean's Office and the Department of Pediatrics and Communicable Diseases has agreed to supply matching funds for one additional Scholar per year for the five-year term of the award.