Racial Disparities Associated with Maternal Exposure to Environmental Endocrine Disrupting Compounds in a Southeastern U.S. Community

美国东南部社区中与母亲接触环境内分泌干扰化合物相关的种族差异

• 批准号: 10056324
• 负责人: Michael S Bloom
• 金额: $ 29.77万
• 依托单位: GEORGE MASON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-24 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10056324
• 关键词: Address; Affect; African American; Age; Analytical Chemistry; Archives; Benzophenones; Beverages; Biological Markers; Biomedical Research; Biometry; Birth; Blood specimen; Clinical; Clinical Data; Collaborations; Communities; Complex Mixtures; Confounding Factors (Epidemiology); Consent; Data; Development; Dimensions; Discipline of obstetrics; Discrimination; Education; Endocrine Disruptors; Endocrine disruption; Ensure; Environmental Pollutants; Epidemiology; Exhibits; Exposure to; Family; Fetal Development; Food; Foundations; Future; Gender; Gestational Age; Goals; Hormonal; Income; Infant; Investigation; Joints; Life Style; Low Birth Weight Infant; Maternal Exposure; Measures; Medical Records; Modeling; Mothers; National Institute of Environmental Health Sciences; Newborn Infant; Outcome; Parabens; Participant; Pharmaceutical Preparations; Phenols; Population; Positioning Attribute; Pregnancy; Pregnant Women; Premature Birth; Prospective cohort study; Psychosocial Stress; Questionnaires; Race; Recording of previous events; Reporting; Reproductive Endocrinology; Reproductive Health; Research; Risk Factors; Second Pregnancy Trimester; Source; South Carolina; Strategic Planning; Third Pregnancy Trimester; Ultrasonography; Umbilical Cord Blood; Urine; Work; adverse birth outcomes; androgenic; anogenital distance; bisphenol A; cohort; environmental agent; epidemiology study; experience; fetal; health disparity; high risk; in utero; innovation; modifiable risk; penis; perceived stress; personal care products; phthalates; pregnant; premature; prenatal exposure; racial disparity; sex; social health determinants; sociodemographics; study population; success; urinary

PROJECT SUMMARY Aims: We propose a prospective cohort study to examine fetal developmental effects from gestational exposure to endocrine disrupting environmental phenols (EPs) and phthalates (PHTs) in African American (AA) and white mothers in a southeastern U.S. obstetrical population. The focus will be on how associations of EPs with fetal developmental outcomes vary by race. We will also explore how co-exposure to both EPs and PHTs influence these associations. Significance: The proposed study will fundamentally advance our understanding of racial disparities in exposure to EPs and how these differences may contribute to reproductive health disparities between AAs and whites. We will also explore the joint effects of gestational co-exposure to a complex mixture of EPs and PHTs on fetal development. This study directly addresses significant gaps in our understanding the impact of highly prevalent EPs and PHTs on fetal development among AAs and lays the foundation for a more definitive future study of the effect of mixed endocrine disrupting exposures on reproductive health disparities. Innovation: The proposed study will be the 1st to leverage a cohort of AA and white mothers and their newborns, to directly assess health disparities in gestational exposure to a mixture of EPs and PHTs with fetal developmental outcomes. It will be one of few studies to assess the impact of mixed gestational exposure to EPs and PHTs and the 1st to capture these data in the southeastern U.S., where disparities in rates of prematurity and low birth weight between AAs and whites is the highest in the U.S. Preliminary Study: This proposal builds upon a prospective cohort study of 8 prevalent urinary PHTs that we previously measured and fetal development among AA and white mothers in Charleston, South Carolina. The results provide strong support for the approach outlined, especially in regard to differential effects by race. Approach: AA (n=152) and white (n=158) mother-infant pairs completed our study between 2011-2014. Participants provided urine and blood specimens during gestation and at delivery, had a detailed mid-gestation fetal ultrasound, completed a study questionnaire about exposure sources and consented to medical records access. We will measure 10 prevalent EPs in archived maternal urine and correlate the concentrations to birth outcomes, newborn anogenital distances and penis dimensions by mid-gestation ultrasound and at delivery. We will explore the impact of co-exposure to EPs and PHTs and how these results vary by race. Successful completion of our project is ensured by the experience of the team, who worked together to complete the previous project, and have the necessary expertise in obstetrics, reproductive endocrinology, analytic chemistry, epidemiology and biostatistical modeling. These data will be used to develop an R01 application to support a more comprehensive and mechanistic future study to address this important biomedical research gap regarding racially disparate developmental effects of fetal exposure to endocrine disrupting compounds.

项目总结 目的：我们提出了一项前瞻性队列研究，以检查妊娠对胎儿发育的影响。 非裔美国人接触内分泌干扰性环境酚(EP)和邻苯二甲酸盐(PHTs) (Aa)美国东南部产科人口中的白人母亲。重点将放在协会如何 有胎儿发育结果的EPs的比例因种族而异。我们还将探索如何同时接触EP和 PHTs会影响这些关联。 意义：拟议的研究将从根本上促进我们对 暴露于EPs以及这些差异如何可能导致AAs之间的生殖健康差异 还有白人。我们还将探索妊娠期共同暴露于EPs和Ep的复杂混合物的联合影响。 PHTs对胎儿发育的影响。这项研究直接解决了我们在理解以下方面的重大差距： 在AAs中高度流行的EPs和PHTs对胎儿发育的影响，并为更明确的 未来关于混合内分泌干扰暴露对生殖健康差异的影响的研究。 创新：拟议的研究将是第一项利用AA和白人母亲及其母亲的队列的研究 新生儿，直接评估孕期接触EPs和PHTs混合物与胎儿的健康差异 发展成果。这将是为数不多的评估混合妊娠暴露的影响的研究之一。 EPS和PHTs是第一个在美国东南部捕获这些数据的公司，在那里 AAS和白人的早产儿和低出生体重在美国是最高的。 初步研究：这项建议建立在我们对8种流行的尿液PHTs进行的前瞻性队列研究的基础上 此前在南卡罗来纳州查尔斯顿测量了再生障碍性贫血和白人母亲的胎儿发育。这个 结果为概述的方法提供了强有力的支持，特别是在种族差异影响方面。 方法：再生障碍性贫血(n=152)和白人(n=158)母婴配对在2011-2014年间完成了我们的研究。 参与者在怀孕期间和分娩时提供了尿液和血液样本，并在怀孕中期进行了详细的检查 胎儿超声波，填写了一份关于接触来源的研究问卷，并同意医疗记录 进入。我们将测量10种流行的母体尿液中的EPs，并将其浓度与出生联系起来 妊娠中期和分娩时超声检查结果、新生儿肛门生殖道距离和阴茎大小。 我们将探索共同暴露于EPs和PHTs的影响，以及这些结果如何因种族而异。成功 我们项目的完成是由团队的经验确保的，他们共同努力完成了 以前的项目，并拥有必要的产科、生殖内分泌学、分析学专业知识 化学、流行病学和生物统计学建模。这些数据将用于开发R01应用程序，以 支持更全面和机械化的未来研究，以解决这一重要的生物医学研究 关于胎儿暴露在内分泌干扰物中的不同种族的发育影响的差距。