Assessing Axonal Fate, Myelination and Visual Function Recovery after New Gene Treatment

评估新基因治疗后轴突命运、髓鞘形成和视觉功能恢复

基本信息

项目摘要

Retinal ganglion cells (RGCs) are the only neuronal type that relays visual information from the retina to the brain. Like other central nervous system (CNS) axons, RGC axons generally do not regenerate following damage, presenting a major obstacle for treating patients with optic nerve trauma or glaucoma. Previously, using optic nerve crush model, we and others have shown that different genetic interventions induce RGC axon regeneration in adult mice. However, despite the considerable numbers of regenerated axons, recovery of visual function has been limited or non-existent. It is generally viewed that axon regeneration alone is not enough to restore meaningful recovery of visual functions after axonal injury. Evidence indicates that remyelination facilitating saltatory conduction is another key step toward attaining functional restoration. Previously, different groups have reported the extent to which regenerated RGC axons are myelinated in adult mice. However, the results have been variable, raising a possibility that remyelination of RGC axons occurs only under certain conditions. Overall, it is unclear whether there is an optimal intervention for inducing both axon regeneration and remyelination. In this proposal, we will test a hypothesis that manipulating certain genes and treatments will permit both axon regeneration and remyelination. In the first aim, we will determine whether regenerated RGC axons are myelinated in the mice receiving different regenerative treatments. In the second aim, we will determine the degree to myelination is attained with myelinating-promoting treatment. Results obtained from these studies will provide valuable information on developing future therapies to regenerate injured retinal axons after trauma or in diseases.
视网膜神经节细胞(RGCs)是唯一一种传递视觉信息的神经元类型

项目成果

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KEVIN Kyung PARK其他文献

KEVIN Kyung PARK的其他文献

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{{ truncateString('KEVIN Kyung PARK', 18)}}的其他基金

3D visualization and Investigation of Retinal Axon Regeneration
视网膜轴突再生的 3D 可视化和研究
  • 批准号:
    10380861
  • 财政年份:
    2021
  • 资助金额:
    $ 23.03万
  • 项目类别:
3D visualization and Investigation of Retinal Axon Regeneration
视网膜轴突再生的 3D 可视化和研究
  • 批准号:
    10180285
  • 财政年份:
    2021
  • 资助金额:
    $ 23.03万
  • 项目类别:
3D visualization and Investigation of Retinal Axon Regeneration
视网膜轴突再生的 3D 可视化和研究
  • 批准号:
    10577812
  • 财政年份:
    2021
  • 资助金额:
    $ 23.03万
  • 项目类别:
Induction and characterization of RGC axon regeneration in a mouse model of glaucoma
青光眼小鼠模型中 RGC 轴突再生的诱导和表征
  • 批准号:
    10285525
  • 财政年份:
    2021
  • 资助金额:
    $ 23.03万
  • 项目类别:
Induction and characterization of RGC axon regeneration in models of glaucoma
青光眼模型中 RGC 轴突再生的诱导和表征
  • 批准号:
    10468991
  • 财政年份:
    2021
  • 资助金额:
    $ 23.03万
  • 项目类别:
Assessing Axonal Fate, Myelination and Visual Function Recovery after New Gene Treatment
评估新基因治疗后轴突命运、髓鞘形成和视觉功能恢复
  • 批准号:
    10220982
  • 财政年份:
    2020
  • 资助金额:
    $ 23.03万
  • 项目类别:
Regeneration and Reconnection of Damaged Optic Nerve
受损视神经的再生和重新连接
  • 批准号:
    8788266
  • 财政年份:
    2013
  • 资助金额:
    $ 23.03万
  • 项目类别:
Regeneration and Reconnection of Damaged Optic Nerve
受损视神经的再生和重新连接
  • 批准号:
    8421490
  • 财政年份:
    2013
  • 资助金额:
    $ 23.03万
  • 项目类别:
Regeneration and Reconnection of Damaged Optic Nerve
受损视神经的再生和重新连接
  • 批准号:
    8601703
  • 财政年份:
    2013
  • 资助金额:
    $ 23.03万
  • 项目类别:

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