Health and Aging Brain among Latino Elders (HABLE-AT(N)) Study

拉丁裔老年人的健康与大脑老化 (HABLE-AT(N)) 研究

• 批准号: 10055904
• 负责人: LEIGH A JOHNSON
• 金额: $ 914.73万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10055904
• 关键词: Address; Age; Age of Onset; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer' s disease related dementia; Amyloid; Amyloid beta-42; Biological; Biological Assay; Biological Markers; Blood; Cerebrum; Clinical; Clinical Trials; Cognitive; Cognitive aging; Communities; Data; Diabetes Mellitus; Diagnosis; Diagnostic; Disease; Elderly; Enrollment; Ethnic Origin; Frequencies; Goals; Growth; Health; Hispanics; Impaired cognition; Infrastructure; Latino; Magnetic Resonance Imaging; Measures; Mental Depression; Methods; Mexican Americans; Nerve Degeneration; Not Hispanic or Latino; Outcome; Parents; Patients; Pilot Projects; Plasma; Population; Positron-Emission Tomography; Prevalence; Prevalence Study; Primary Prevention; Proteomics; Publications; Race; Research; Risk; Risk Factors; Science; Secondary Prevention; Statistical Models; System; Testing; Underrepresented Groups; Underserved Population; Work; aging brain; apolipoprotein E-4; base; blood-based biomarker; caucasian American; clinical Diagnosis; cohort; cost; design; differential expression; exosome; experience; follow-up; health disparity; mild cognitive impairment; modifiable risk; neuroimaging; novel; pre-clinical; prevent; primary care setting; prodromal Alzheimer' s disease; racial and ethnic; screening; specific biomarkers; tau Proteins; tertiary prevention; tool

PROJECT SUMMARY The 2018 NIA - Alzheimer's Association Research Framework [AT(N)] for Alzheimer's Disease (AD) provides a biological context for studying AD by incorporating state-of-the art biomarkers of amyloid (A), tau (T) and neurodegeneration (N). Despite the fact that these biomarkers vary by race/ethnicity, no prior work has systematically examined them among Mexican Americans. Given that (1) Hispanic/Latinos are projected to experience the largest growth in AD and Alzheimer's Disease Related Dementias (ADRDs) by 2060 and (2) Mexican Americans are the largest segment of the U.S. Hispanic/Latino population, there is a pressing need to study prevalence, progression and clinical impact of these biomarkers among this underrepresented group. This work addresses goals of the National Alzheimer's Project Act (NAPA), NIA Milestones for AD and ADRD research, and needs highlighted by the AT(N) framework publication. The current research team consists of leading experts in Mexican American cognitive aging, neuroimaging (PET and MRI), blood-based biomarkers as well as advanced statistical modeling. By leveraging the ongoing HABLE cohort, infrastructure and data, we will test the following Specific Aims: Aim 1: Examine the prevalence, progression and clinical impact of cerebral markers of the 2018 AT(N) framework among community-dwelling Mexican Americans. Aim 2. Examine the prevalence, progression and clinical impact of blood markers of the 2018 AT(N) framework among community-dwelling Mexican Americans. Aim 3: To determine if blood-based biomarkers of Aβ40, Aβ42, tau and NfL can be used to screen for AT(N)-defined preclinical AD, prodromal AD and AD dementia for enrollment of Mexican Americans into novel clinical trials. The current study is highly significant for several reasons: (1) This is the first-ever large-scale multi-ethnic study of the AT(N) biomarkers, which is of tremendous importance given the racial/ethnic make-up of the U.S. population; (2) this work directly addresses goals set forth by NAPA as well NIA-Milestones for AD/ADRD science; (3) it will determine if ethnic-specific biomarker trajectories are appropriate and finally, (4) it will generate data and methods for increasing enrollment of Hispanics into clinical trials across the AT(N)-defined spectrum of AD (primary, secondary and tertiary prevention) beginning in primary care settings.

项目总结