The Role of Dietary Nutrients in Chronic Kidney Disease Progression and Apolipoprotein L1 Nephropathy

膳食营养素在慢性肾脏病进展和载脂蛋白 L1 肾病中的作用

• 批准号: 10055616
• 负责人: Titilayo Omolara Ilori
• 金额: $ 18.74万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10055616
• 关键词: Address; Africa; Africa South of the Sahara; African; African American; American; Anti-Inflammatory Agents; Apolipoproteins; Biological Markers; Biometry; Blood Pressure; Boston; Career Choice; Cessation of life; Chronic Kidney Failure; Collection; Cross-Sectional Studies; Data Analyses; Development; Diabetes Mellitus; Dialysis procedure; Diet; Dietary Factors; Dietary Fiber; Dietary Potassium; Dietary Practices; Dietary Sodium; Dietary intake; Disease; Disease Progression; Elements; End stage renal failure; Environmental Exposure; Environmental Risk Factor; Europe; Excretory function; Funding; Gene Expression; Genes; Genetic; Genetic Risk; Genomics; Genotype; Health; High Prevalence; Human; Incidence; Individual; Inflammasome; Inflammation; Inflammatory; Inherited; Injury to Kidney; Institutes; Intake; Intervention Studies; K-Series Research Career Programs; Kidney; Kidney Diseases; Kidney Transplantation; Life; Life Style; Link; Maintenance; Malignant - descriptor; Measures; Minority; Modification; National Institute of Diabetes and Digestive and Kidney Diseases; Nutrient; Outcome; Oxalates; Parents; Participant; Patients; Phenotype; Population; Potassium; Potassium Oxalate; Prospective Studies; Prospective cohort study; Public Health; Renal function; Research; Research Project Grants; Resources; Risk; Risk Factors; Role; Sodium; Testing; Toxic effect; Training; Transplantation; Universities; Urine; Variant; biobank; career; cost; design; disease phenotype; disorder risk; early onset; fruits and vegetables; gene environment interaction; gene interaction; genetic epidemiology; genetic risk factor; global health; health disparity; high risk; medical schools; mitochondrial dysfunction; modifiable risk; nephrotoxicity; new therapeutic target; novel; nutrition; nutritional epidemiology; patient oriented research; professor; prospective; public health research; risk variant; skills; urinary

PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) individuals Among malignant Apolipoprotein L1 (APOL1). Approximately 13% of African Americans and 25% of West Africans carry high risk renal genotypes, comprising of any combination of the two APOL1 risk variants, G1 and G2. This re-submission for a National Institute of Diabetes and Digestive Kidney Diseases Patient-Oriented Research Career Development Award (K23) seeks to support Dr. Titilayo Ilori, an Assistant Professor at the Boston University School of Medicine, who wants to build a career focused on mechanistic and interventional studies on the effect of dietary factors and lifestyle on CKD incidence and progression in both low- and adequately-resourced settings, especially in the context of genetic and genomic risk variants. Dr. Ilori's prior research has focused on health disparities in CKD and secondary data analysis of nutrition-related exposures and outcomes in kidney disease. Dr. Ilori intends to extend the scope of her research towards designing prospective studies to study the role of dietary sodium and potassium in CKD progression and APOL1 Nephropathy in Africans. Accordingly, her K23 training is focused on acquiring skills in global health research, nutritional and genetic epidemiology in CKD, statistical genetics and advanced biostatistics skills in longitudinal data analysis, and biomarkers of CKD. We propose a research project that leverages the Human Hereditary and Health in Africa Kidney Disease Research Network and addresses the following research aims: 1) a cross-sectional and prospective examination of the associations of dietary sodium, potassium, and oxalate intake – assessed through 24h urine collections in Africans; 2) a cross-sectional and prospective study to determine the associations of dietary patterns with CKD and CKD progression; 3) diet:gene interaction studies to examine whether dietary factors (sodium, potassium, oxalate, or dietary patterns) modify the effect of association of APOL1 renal genotypes on CKD progression. This is an important project because it may identify if dietary factors are modifiable risk factors for CKD progressions in Africans in SSA, where the cost of dialysis and renal transplantation is prohibitive. Additionally, evidence that diet alters the risk of nephropathy in those with high-risk APOL1 renal risk alleles could be important in investigating new therapeutic targets for APOL1 Nephropathy. is effectively a “death sentence” in Sub-Saharan Africa (SSA) where <2% of with end stage renal disease (ESRD) have access to maintenance dialysis or transplantation. Africans with CKD, there is a faster decline in kidney function and earlier onset of ESRD. This CKD phenotype is largely attributable to variants in the gene encoding

项目总结/文摘