HaloFilm: a spray-on, re-chargeable, re-applicable antimicrobial coating

项目总结/摘要 在美国，每年约有170万例医疗相关感染（HAl）发生在医院。 每年，造成99，000人死亡，估计医疗费用为200亿美元。根据 根据以前的报告，多达三分之一的HAI病例可归因于环境因素， 表面，即“高接触”表面（例如床轨、机器按钮、设备）， 医院自消毒涂层，即抗菌表面，是理想的理论解决方案， 消除持久性病原体;然而， 抗菌材料，可以满足所有要求的高效率对病原体：容易 应用上，材料兼容性广泛，不会产生病原体抗性，且具有成本效益。 这使得HaloFilm™成为一个突破性的产品。HaloFilm是一种喷雾产品， 干燥后在表面上留下一层透明的薄膜。薄膜是一种聚合物， 一种是用于粘附到表面的单体，另一种是用于稳定氯的单体，即N-卤胺。 HaloFilm将表面变成氯电池，因此即使使用家用品牌的消毒剂也会 留下一个表面覆盖着氯，可以持续两个星期以上。HaloFilm拥有 与最常用的抗菌剂银相比， 因为它依赖于氯的功效，而氯已经使用了几十年， 有效对抗病原体而不产生具有抗性的病原体。 此外，我们最近开发了一种配方，其中包括防污单体， 部分和聚（乙二醇）。这些对聚合物主链的加成意味着， HaloFilm即使不带氯也能有效。该项目将评估 具有这两种防污单体的HaloFilm与不具有它们的HaloFilm相比。最好的 然后将测试制剂的功效和安全性。 HaloFilm是Halamine Inc。的第一个产品，并受独家授权专利的保护， 奥本大学和康奈尔大学。

Project Summary/Abstract In the US, about 1.7 million Healthcare-Associated Infections (HAls) occur in hospitals each year, resulting in 99,000 deaths and an estimated $20 billion in healthcare costs. According to previous reports, as much as one third of HAI cases can be attributed to environmental surfaces, namely “high touch” surfaces (e.g. bed rails, machine buttons, equipment), in a hospital. Self-sanitizing coatings, i.e. antimicrobial surfaces, are an ideal theoretical solution for eliminating persistent pathogens; however there has been no commercially available antimicrobial material which can fulfill all requirements of high-efficacy against pathogens: easy to apply, broad material compatibility, no pathogen resistance development, and cost-effective. That makes HaloFilm™ a breakthrough product. HaloFilm is a spray-on product that when dried leaves a thin transparent film on a surface. The film is a polymer composed of one monomer to stick to the surface, and another monomer that stabilizes chlorine, i.e. N-halamine. HaloFilm turns the surface into a chlorine battery so using even a household brand sanitizer will leave a surface covered with chlorine which can last longer than two weeks. HaloFilm has superior efficacy against pathogens compared to the most popular antimicrobial agent, silver, because it relies on the efficacy of chlorine which has decades of use, and broad-spectrum efficacy against pathogen without generating pathogens with resistance. In addition, we recently developed a formulation that include anti-fouling monomers, zwitterion moieties and poly(ethylene glycol). These additions to the polymer backbone mean that HaloFilm can be effective even without being charged with chlorine. This project will evaluate HaloFilm with these two anti-fouling monomers against HaloFilm without them. The best formulation will then be tested for efficacy and safety. HaloFilm is Halamine Inc.’s first product and is protected by exclusively licensed patents from Auburn University and Cornell University.