HaloFilm: a spray-on, re-chargeable, re-applicable antimicrobial coating

HaloFilm：一种喷涂式、可充电、可重复涂抹的抗菌涂层

• 批准号: 10079763
• 负责人: Mingyu Qiao
• 金额: $ 25.03万
• 依托单位: HALOMINE, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-05 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10079763
• 关键词: Adhesions; Affect; Antibiotics; Antidotes; Antimicrobial Effect; Antimicrobial Resistance; Bacteria; Beds; Biological; Cessation of life; Charge; Chemicals; Chemistry; Chlorine; Clinical Trials; Consumption; Data; Development; Dopa; Effectiveness; Equipment; Evaluation; Film; Formulation; Goals; Hand; Health Care Costs; Health Personnel; Health care facility; Hospitals; Household; Human; In Vitro; Infection; Intellectual Property; Legal patent; Link; Medical Device; Methods; Mussels; Nosocomial Infections; Paint; Patient Discharge; Patients; Patients' Rooms; Phase; Polymers; Procedures; Property; Proteins; Protocols documentation; Reporting; Residual state; Resistance; Resistance development; Rubber; Safety; Sanitation; Silver; Skin; Source; Stainless Steel; Structure; Surface; System; Techniques; Testing; Thinness; Time; Touch sensation; Toxic effect; Universities; Vertebral column; Virus; Visual; antimicrobial; antimicrobial drug; base; cost; cost effective; cytotoxicity; efficacy testing; ethylene glycol; fungus; health care settings; healthcare-associated infections; in vitro testing; innovation; invention; meetings; microbial; migration; minimal risk; monomer; novel; pathogen; relative effectiveness; skin irritation; tool

Project Summary/Abstract In the US, about 1.7 million Healthcare-Associated Infections (HAls) occur in hospitals each year, resulting in 99,000 deaths and an estimated $20 billion in healthcare costs. According to previous reports, as much as one third of HAI cases can be attributed to environmental surfaces, namely “high touch” surfaces (e.g. bed rails, machine buttons, equipment), in a hospital. Self-sanitizing coatings, i.e. antimicrobial surfaces, are an ideal theoretical solution for eliminating persistent pathogens; however there has been no commercially available antimicrobial material which can fulfill all requirements of high-efficacy against pathogens: easy to apply, broad material compatibility, no pathogen resistance development, and cost-effective. That makes HaloFilm™ a breakthrough product. HaloFilm is a spray-on product that when dried leaves a thin transparent film on a surface. The film is a polymer composed of one monomer to stick to the surface, and another monomer that stabilizes chlorine, i.e. N-halamine. HaloFilm turns the surface into a chlorine battery so using even a household brand sanitizer will leave a surface covered with chlorine which can last longer than two weeks. HaloFilm has superior efficacy against pathogens compared to the most popular antimicrobial agent, silver, because it relies on the efficacy of chlorine which has decades of use, and broad-spectrum efficacy against pathogen without generating pathogens with resistance. In addition, we recently developed a formulation that include anti-fouling monomers, zwitterion moieties and poly(ethylene glycol). These additions to the polymer backbone mean that HaloFilm can be effective even without being charged with chlorine. This project will evaluate HaloFilm with these two anti-fouling monomers against HaloFilm without them. The best formulation will then be tested for efficacy and safety. HaloFilm is Halamine Inc.’s first product and is protected by exclusively licensed patents from Auburn University and Cornell University.

项目摘要/摘要 在美国，约有170万人在医院发生医疗相关感染(HAL) 去年，导致99,000人死亡，估计医疗费用为200亿美元。根据 此前有报道称，高达三分之一的禽流感病例可归因于环境因素 表面，即“高接触”表面(例如，床轨、机器按钮、设备)，在 医院。自消毒涂层，即抗菌表面，是一种理想的理论解决方案 消除持久性病原体；然而，目前还没有商业上可用的 能满足所有对病原体高效的要求的抗菌材料：简单 适用范围广，材料配伍性广，无病原菌抗性发展，性价比高。 这使得光环胶片™成为一款突破性产品。卤化胶片是一种喷雾产品，当 干燥的叶子表面有一层薄而透明的薄膜。该薄膜是一种聚合物，由一种 另一种是稳定氯的单体，即N-卤胺。 卤膜将表面变成氯电池，所以即使使用家用品牌的消毒剂也可以 表面要留有氯气覆盖，可持续两周以上。光晕胶片有 与最流行的抗菌剂银剂相比，对病原体的疗效更好。 因为它依赖于氯的功效，它已经使用了几十年，而且光谱很广 对病原体有效，不产生抗药性的病原体。 此外，我们最近开发了一种配方，其中包括防污单体zwitterion 部分和聚乙二醇组分。这些对聚合物主干的添加意味着 即使不用氯充电，卤素薄膜也可以有效。该项目将评估 含有这两种防污单体的卤素胶片与不含它们的卤素胶片进行对比。最好的 然后将对配方进行有效性和安全性测试。 卤素胶片是卤素公司S的第一款产品，受 奥本大学和康奈尔大学。