Task E04: SCREENING OF RODENT PHARMACOKINETICS FOR LEAD OPTIMIZATION

任务 E04：筛选啮齿动物药代动力学以优化先导化合物

• 批准号: 10075197
• 负责人: JACOB BODE
• 金额: $ 2.25万
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-18 至 2020-07-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10075197
• 关键词: Antimicrobial Resistance; Chemistry; Communicable Diseases; Development; Development Plans; Drug Kinetics; Evaluation; In Vitro; Interventional Agent Development; Lead; Microbiology; Rodent; Safety; Services; Support Contracts; Therapeutic; Toxicology; Toxin; bacterial resistance; in vivo; lead optimization; pathogen; pre-clinical; product development; programs; screening; therapeutic development

The Non-clinical Services for Development of Interventional Agents for Infectious Diseases program provides services to facilitate preclinical product development of promising therapeutics for infectious disease-causing pathogens and/or toxins. Services include: preclinical product development planning and evaluation; lead identification and development; chemistry and GMP manufacturing; in vitro and in vivo preclinical microbiological, safety, toxicology and pharmacokinetics.

传染病干预药物开发非临床服务项目提供服务，以促进有前景的传染病病原体和/或毒素治疗药物的临床前产品开发。服务包括：临床前产品开发计划和评价;先导化合物鉴定和开发;化学和GMP生产;体外和体内临床前微生物、安全性、毒理学和药代动力学。