Task E08: Lead Optimization Screening Assays for ADMET and Safety Profiling

任务 E08：ADMET 和安全性分析的先导化合物优化筛选分析

• 批准号: 10440007
• 负责人: JACOB BODE
• 金额: $ 21.48万
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10440007
• 关键词: Acinetobacter; Antimicrobial Resistance; Biological Assay; Chemistry; Communicable Diseases; Development; Development Plans; Drug Kinetics; Evaluation; Gram-Negative Bacteria; Gram-Positive Bacteria; In Vitro; Interventional Agent Development; Lead; Microbiology; Safety; Services; Support Contracts; Therapeutic; Toxicology; Toxin; gram negative facultative rods; in vivo; lead optimization; pathogen; pre-clinical; product development; programs; screening; therapeutic development

The Non-clinical Services for Development of Interventional Agents for Infectious Diseases program provides services to facilitate preclinical product development of promising therapeutics for infectious disease-causing pathogens and/or toxins. Services include: preclinical product development planning and evaluation; lead identification and development; chemistry and GMP manufacturing; in vitro and in vivo preclinical microbiological, safety, toxicology and pharmacokinetics.

传染病干预药物开发非临床服务项目提供服务，以促进有前景的传染病病原体和/或毒素治疗药物的临床前产品开发。服务包括：临床前产品开发计划和评价;先导化合物鉴定和开发;化学和GMP生产;体外和体内临床前微生物、安全性、毒理学和药代动力学。