Acceptance and Commitment Therapy for Fatigue Interference in Metastatic Breast Cancer

转移性乳腺癌疲劳干扰的接受和承诺疗法

• 批准号: 10112844
• 负责人: Catherine E Mosher
• 金额: $ 41.44万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-08 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10112844
• 关键词: Acceptance Process; Address; Advanced Malignant Neoplasm; Anxiety; Attention; Awareness; Behavior Therapy; Behavioral; Breast Cancer Patient; Breast Cancer survivorship; Cancer Patient; Caring; Chronic; Cognition; Cognitive; Cognitive Therapy; Distress; Education; Evidence based intervention; Exercise; Face; Family; Fatigue; Feeling; Geography; Goals; Group Therapy; Impairment; Intervention; Malignant Neoplasms; Malignant neoplasm of ovary; Mediating; Mediator of activation protein; Medical; Meditation; Meta-Analysis; Metastatic breast cancer; Metastatic to; Moods; Neurobehavioral Manifestations; Outcome; Pain interference; Palliative Care; Patient Care; Patients; Persons; Pharmacology; Phase; Pilot Projects; Population; Process; Psychotherapy; Quality of life; Randomized; Randomized Controlled Trials; Reporting; Sampling; Sleep; Sleep Disorders; Source; Symptoms; Telephone; Testing; Therapeutic Intervention; Thinking; Time; Treatment Efficacy; United States; Woman; Work; anxiety symptoms; base; behavior change; cancer diagnosis; clinical care; depressive symptoms; disability; disabling symptom; efficacy evaluation; evidence base; experience; flexibility; functional decline; functional disability; functional outcomes; improved; innovation; malignant breast neoplasm; mindfulness; negative affect; novel; novel strategies; phase II trial; physical symptom; pilot trial; post intervention; primary outcome; programs; psychologic; randomized trial; reduce symptoms; secondary outcome

Project Summary/Abstract Fatigue interference with activities, mood, and cognition is one of the most prevalent and distressing concerns of metastatic breast cancer patients. To date, there are no evidence-based interventions for reducing fatigue interference in metastatic breast cancer patients and other advanced cancer populations. In pilot studies, Acceptance and Commitment Therapy (ACT) has shown potential for reducing symptom-related suffering in cancer patients. We recently conducted a pilot study in metastatic breast cancer that tested a novel telephone- based ACT intervention combining mindfulness exercises (e.g., meditations, performing activities with greater awareness) with identification of personal values and engagement in activities consistent with these values. The intervention showed strong evidence of feasibility, acceptability, and promise with respect to reducing fatigue interference with activities, mood, and cognition. The proposed Phase II trial seeks to more definitively examine the efficacy of our telephone-based ACT intervention for women with metastatic breast cancer who are experiencing fatigue interference. In this trial, 250 women will be randomly assigned in equal numbers to either the ACT intervention or an education/support control condition. Women in both conditions will attend six weekly 50-minute telephone sessions. The primary aim of this study is to test the effect of telephone-based ACT on fatigue interference. Secondary outcomes include sleep interference, engagement in daily activities, and quality of life. Outcomes will be assessed at baseline, 2 weeks post-intervention, and 3 and 6 months post- intervention. This trial will also examine whether increases in psychological flexibility, defined as full awareness of the present moment while persisting in action aligned with personal values, account for the beneficial effect of ACT on fatigue interference. After demonstrating ACT's efficacy, the intervention can be widely disseminated to metastatic breast cancer patients. This trial will also lay the groundwork for further application and testing of ACT with a wide range of cancer populations and functional outcomes.

项目总结/文摘