Cell Biology Program

细胞生物学研究项目总结 癌症通常被称为“细胞生物学问题”，其中遗传异常或环境异常导致癌症。 损伤诱导基本细胞功能如基因调节、细胞分裂、细胞粘附 受体信号传导和运输以及分化。马约诊所癌症中心的中心目标是 （MCCC）细胞生物学计划是为了确定肿瘤转化的分子遗传学和细胞基础， 生长和转移，同时提供对细胞生长和衰老，器官发育， 染色质动力学和基因组改变。MCCC细胞生物学项目包括来自16个国家的34名成员。 不同的部门共同带来了大量基于癌症的NIH资金（450万美元，56% NCI）。这些成员在广泛的癌症领域进行研究，重点是4 具体目标：1）研究细胞周期调控的基本遗传和表观遗传机制 正常、衰老和肿瘤细胞中的转录调控; 2）通过 哪些细胞信号传导途径和受体内吞活性促进不受控制的细胞生长; 3） 确定癌细胞及其微环境之间的串扰如何促进癌症生长， 调节新血管生成、炎症、免疫逃避和纤维化;以及4）了解细胞如何 附着于基质和彼此，以及当细胞开始迁移时这些附着如何改变， 入侵细胞生物学计划研究与发展或预防相关的细胞过程， 广泛的人类癌症和广泛的接口与其他MCCC计划。除了 进行创新和尖端癌症相关的研究，细胞生物学计划组织和 赞助许多互动的科学聚会，包括国家和国际会议，并提供一个 马约诊所的基础癌症生物学中心。在我们发表的483篇癌症相关论文中， 在2013年至2017年期间，66名成员为方案内成员，235名成员为方案间成员， 该计划为癌症中心带来的高附加值。

CELL BIOLOGY PROGRAM PROJECT SUMMARY Cancer is commonly referred to as a “cell biological problem” in which genetic abnormalities or environmental insults induce profound changes in basic cellular functions such as gene regulation, cell division, cell adhesion, receptor signaling and trafficking, and differentiation. The central goal of the Mayo Clinic Cancer Center (MCCC) Cell Biology Program is to define the molecular genetic and cellular basis of neoplastic transformation, growth, and metastasis while providing insights into cell growth and senescence, organ development, chromatin dynamics, and genomic alterations. The MCCC Cell Biology Program includes 34 members from 16 different departments that collectively bring in substantial cancer-based NIH funding ($4.5M directs with 56% from the NCI). These members conduct research across a broad spectrum of cancers, which is focused in 4 specific aims: 1) To investigate the fundamental genetic and epigenetic mechanisms regulating the cell cycle and transcription control in normal, senescent, and neoplastic cells; 2) To elucidate the mechanisms through which cell signaling pathways and receptor endocytic activity promote uncontrolled cell growth; 3) To determine how the crosstalk between cancer cells and their microenvironment promotes cancer growth by regulating neo-angiogenesis, inflammation, immune evasion, and fibrosis; and 4) To understand how cells attach to substrates and to each other, and how these attachments are altered as a cell initiates migration and invasion. The Cell Biology Program studies cellular processes relevant to the development or prevention of a broad spectrum of human cancers and broadly interfaces with other MCCC Programs. In addition to conducting innovative and cutting-edge cancer-relevant research, the Cell Biology Program organizes and sponsors many interactive scientific gatherings, including national and international meetings, and provides a central hub for basic cancer biology at Mayo Clinic. Of the 483 cancer-relevant papers published by our members between 2013 and 2017, 66 were intraprogrammatic and 235 were interprogrammatic, underscoring the high value added by the Program to the Cancer Center.