Methods for Mendelian randomization and mediation analysis using integrative genetic and genomic data for breast cancer
使用乳腺癌综合遗传和基因组数据进行孟德尔随机化和中介分析的方法
基本信息
- 批准号:10115425
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAfricanApplications GrantsAsiansAutomobile DrivingBiologicalBiometryBreastBreast Cancer Risk FactorConfidence IntervalsDataData SetDevelopmentDevelopment PlansDiseaseDoctor of PhilosophyEnvironmentEpidemiologyEthnic OriginEtiologyEuropeanEventGeneticGenetic ResearchGenomeGenomicsGoalsHormonesInstitutionInvestigationKnowledgeLatinoLeadLeadershipLifeLinkMalignant NeoplasmsMediatingMediationMendelian randomizationMentorsMethodologyMethodsMolecular BiologyOutcomePaperPathway interactionsPerformancePopulationPostdoctoral FellowPrevention strategyPublic Health SchoolsResearchResearch PersonnelResource DevelopmentRiskRisk FactorsTechniquesTestingTrainingUniversitiesVariantWomanWorkWritinganalytical toolanticancer researchbiobankbiological researchcancer subtypescareercareer developmentclinical decision-makingcourse developmentdisease phenotypeexperiencefunctional genomicsgenetic associationgenetic variantgenome wide association studygenomic datagenomic locusindividualized medicineindividualized preventioninsightmalignant breast neoplasmmeetingsmolecular markermolecular subtypesmulti-ethnicmultidisciplinarynovelnovel strategiesnovel therapeuticspersonalized therapeuticpolygenic risk scorereproductivesimulationskillsstatisticstooltreatment strategyuser-friendly
项目摘要
Project summary
Haoyu Zhang, PhD is a statistician whose ultimate career goal is incorporating advanced causal inference
techniques into genetics and biological research in order to make impactful advances in epidemiological and
clinical decision-making. The research he proposes will develop powerful causal inference approaches to
identify causal risk factors and underlying genetic pathways leading to the risk of breast cancer.
Candidate: Dr. Zhang is a postdoctoral fellow in the Department of Biostatistics at Harvard T.H. Chan School
of Public Health (HSPH). He completed a Ph.D. in Biostatistics at Johns Hopkins University. His previous work
in breast cancer genome-wide association studies (GWAS) focusing on identifying genetic associations and
building polygenic risk has prepared him to conduct the proposed research. The proposed career development
plan will build upon his previous training with three training goals to enhance trajectory toward becoming an
independent investigator: 1) acquire and apply cutting edge causal inference methodologies to apply on large
genetic datasets; 2) gain knowledge in molecular biology and cancer; 3) develop leadership and professional
skills to conduct multidisciplinary analysis.
Mentors/Environment: Dr. Zhang has assembled a strong mentoring committee with complementary
expertise in the required fields for the proposed research. All the mentors have committed to meet with him in a
regular basis and participate the advisory meeting to oversight his training and research progress every six
months. As an institution, HSPH is committed to help young researchers. Dr. Zhang will have access to
professional and career development resources, which include professional development courses, writing and
editing support for papers and grant applications, etc.
Research: Risk factors for the breast cancer include reproductive and life events (collectively classic risk
factors) and genetic factors; however, the causal associations and pathways linking these risk factors with
breast cancer are unclear. To solve these two issues, He will develop a robust and powerful approach for
Mendelian randomization analysis to estimate the causal effects between classic risk factors and breast cancer
risk (Aim 1). He will also develop a causal mediation approach integrating functional annotation datasets to
identify the underlying pathways for breast cancer risk (Aim 2). In Aim 3, he will apply both the standard
approaches and novel approaches developed in Aim 1 and 2 on the largest breast cancer GWAS dataset from
the multi-ethnic Confluence Project. The results of this proposal will provide advanced statistical tools to
identify causal effect, elucidate the underlying genetic pathways and guide developments of personalized
therapeutics and prevention strategies. The proposal will also provide him the required training and research
experience to become an independent research with casual inference and breast cancer expertise.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Haoyu Zhang其他文献
Haoyu Zhang的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Haoyu Zhang', 18)}}的其他基金
Methods for Mendelian randomization and mediation analysis using integrative genetic and genomic data for breast cancer
使用乳腺癌综合遗传和基因组数据进行孟德尔随机化和中介分析的方法
- 批准号:
10319172 - 财政年份:2021
- 资助金额:
$ 10万 - 项目类别:
相似海外基金
Tracing the African roots of Sri-Lanka Portuguese
追溯斯里兰卡葡萄牙语的非洲根源
- 批准号:
AH/Z505717/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Research Grant
Bovine herpesvirus 4 as a vaccine platform for African swine fever virus antigens in pigs
牛疱疹病毒 4 作为猪非洲猪瘟病毒抗原的疫苗平台
- 批准号:
BB/Y006224/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Research Grant
Commercialisation of African Youth Enterprise Programme
非洲青年企业计划商业化
- 批准号:
ES/Y010752/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Research Grant
Resilient and Equitable Nature-based Pathways in Southern African Rangelands (REPAiR)
南部非洲牧场弹性且公平的基于自然的途径 (REPAiR)
- 批准号:
NE/Z503459/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Research Grant
Evaluating the effectiveness and sustainability of integrating helminth control with seasonal malaria chemoprevention in West African children
评估西非儿童蠕虫控制与季节性疟疾化学预防相结合的有效性和可持续性
- 批准号:
MR/X023133/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Fellowship
Understanding differences in host responses to African swine fever virus
了解宿主对非洲猪瘟病毒反应的差异
- 批准号:
BB/Z514457/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Fellowship
The impact on human health of restoring degraded African drylands
恢复退化的非洲旱地对人类健康的影响
- 批准号:
MR/Y019806/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Research Grant
CAREER: Habitability of the Hadean Earth - A South African perspective
职业:冥古宙地球的宜居性——南非的视角
- 批准号:
2336044 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Continuing Grant
Nowcasting with Artificial Intelligence for African Rainfall: NAIAR
利用人工智能预测非洲降雨量:NAIAR
- 批准号:
NE/Y000420/1 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Research Grant
Assessing the role of the lithospheric mantle during passive margin development - insights from the South Atlantic African margin
评估岩石圈地幔在被动边缘发育过程中的作用 - 来自南大西洋非洲边缘的见解
- 批准号:
2305552 - 财政年份:2024
- 资助金额:
$ 10万 - 项目类别:
Standard Grant