PQ6: Transgenic Mouse Model for Kaposi Sarcoma
PQ6:卡波西肉瘤转基因小鼠模型
基本信息
- 批准号:10115683
- 负责人:
- 金额:$ 52.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-03-01 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:AIDS related cancerAIDS/HIV problemAgeAnimal ModelAnimalsAnniversaryAntiviral AgentsBypassCD4 Lymphocyte CountCRISPR/Cas technologyCell LineCellsCellular StructuresDNA DamageDataDevelopmentDoxorubicinDoxorubicin Hydrochloride LiposomeDrug ModelingsEvaluationFRAP1 geneFrequenciesGanciclovirGene Expression ProfileGenerationsGenesGenetic TranscriptionGenomeHIVHIV SeronegativityHemangiosarcomaHerpesviridaeHumanHuman Herpesvirus 8ImmuneImmunocompetentIn VitroIncidenceKaposi SarcomaKnowledgeLesionLymphomaLyticMalignant NeoplasmsMapsModelingMolecularMolecular TargetMusNeoplasm TransplantationPathogenesisPathway interactionsPersonsPharmaceutical PreparationsPhasePlatelet-Derived Growth FactorProteinsRegimenResearchSafetySignal TransductionStructureStudy modelsTestingTissuesTranscriptTransgenic MiceTransgenic ModelTransplantationTumor-DerivedVaccinesVascular Endothelial Growth FactorsViralViral GenesViral GenomeViral Load resultViral OncogeneVirus Latencyantiretroviral therapycell typecohortcommon treatmentdrug candidatedrug developmentdrug testinghuman fetus tissuein vivoin vivo ModelmTOR Inhibitormouse modelneoplastic cellnovelnovel therapeuticspomalidomidepreventpreventive interventionresponsetargeted treatmenttumortumorigenesisvaccine developmentvaccine evaluation
项目摘要
Project Summary Abstract
After 25 years there is still is no adequate animal model for Kaposi Sarcoma (KS), which is the most common
cancer in people living with HIV/AIDS world-wide. Notably, KS develops even in HIV-infected person with
normal CD4 counts and no detectable HIV viral load, as well as in HIV-negative persons – so called classic
KS. The KS-associated herpesvirus (KSHV) is necessary for KS. Rather than focusing on one specific viral
gene, we inserted the entire 138,146 bp KSHV viral genome into transgenic mice. These develop
angiosarcoma and the KSHV genes are expressed in the tumor. This proposal seeks to understand the
mechanism of KS tumorigenesis and to study known and novel drug candidates. This proposal responds to
NCI provocative question six: “Can novel in vitro and in vivo models of HIV/AIDS-associated malignancies be
developed to study their development, pathogenesis, and the potential evaluation of
novel treatments for common HIV/AIDS-associated malignancies?”
项目摘要摘要
25年后,最常见的卡波西肉瘤(KS)仍然没有合适的动物模型
世界范围内艾滋病毒/艾滋病感染者的癌症。值得注意的是,KS即使在HIV感染者中也会发生
CD4计数正常,没有检测到艾滋病毒病毒载量,以及艾滋病毒阴性的人--所谓的经典
KS.KS相关疱疹病毒(KSHV)是KS所必需的。而不是专注于一种特定的病毒
我们将KSHV病毒全长138,146个碱基的基因组插入转基因小鼠体内。这些都会发展
血管肉瘤和KSHV基因在肿瘤中表达。这项提议试图理解
KS肿瘤发生机制及已知和新药候选药物的研究。这项提议回应了
NCI挑衅性问题六:新的艾滋病毒/艾滋病相关恶性肿瘤的体外和体内模型是否可以
旨在研究它们的发展、发病机制和潜在的评估
常见的艾滋病毒/艾滋病相关恶性肿瘤的新治疗方法?
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dirk P Dittmer其他文献
Determinants of mTOR inhibitor therapy in AIDS-associated malignancies
- DOI:
10.1186/1750-9378-7-s1-o9 - 发表时间:
2012-04-19 - 期刊:
- 影响因子:2.800
- 作者:
Dirk P Dittmer;Blossom Damania;Sang-Hoon Sin;Debasmita Roy - 通讯作者:
Debasmita Roy
The use of high-dose azidothymidine in combination with chemotherapy upfront is an effective treatment approach for gamma-herpes virus-related non-Hodgkin’s lymphomas
- DOI:
10.1186/1750-9378-5-s1-a81 - 发表时间:
2010-10-11 - 期刊:
- 影响因子:2.800
- 作者:
Ulas Darda Bayraktar;Eileen Bernal;Lisa Cabral;William J Harrington;Dirk P Dittmer;Juan Carlos Ramos - 通讯作者:
Juan Carlos Ramos
Dirk P Dittmer的其他文献
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{{ truncateString('Dirk P Dittmer', 18)}}的其他基金
PQ6: Transgenic Mouse Model for Kaposi Sarcoma
PQ6:卡波西肉瘤转基因小鼠模型
- 批准号:
10334549 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Project 2: Clinical and molecular determinants of HIV-associated Kaposi Sarcoma progression under local standard-of-care therapy in Malawi and South Africa
项目 2:马拉维和南非当地标准护理治疗下 HIV 相关卡波西肉瘤进展的临床和分子决定因素
- 批准号:
10434864 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Project 2: Clinical and molecular determinants of HIV-associated Kaposi Sarcoma progression under local standard-of-care therapy in Malawi and South Africa
项目 2:马拉维和南非当地标准护理治疗下 HIV 相关卡波西肉瘤进展的临床和分子决定因素
- 批准号:
10652401 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Project 2: Clinical and molecular determinants of HIV-associated Kaposi Sarcoma progression under local standard-of-care therapy in Malawi and South Africa
项目 2:马拉维和南非当地标准护理治疗下 HIV 相关卡波西肉瘤进展的临床和分子决定因素
- 批准号:
10084558 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Project 2: Clinical and molecular determinants of HIV-associated Kaposi Sarcoma progression under local standard-of-care therapy in Malawi and South Africa
项目 2:马拉维和南非当地标准护理治疗下 HIV 相关卡波西肉瘤进展的临床和分子决定因素
- 批准号:
10238161 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
PQ6: Transgenic Mouse Model for Kaposi Sarcoma
PQ6:卡波西肉瘤转基因小鼠模型
- 批准号:
10579826 - 财政年份:2020
- 资助金额:
$ 52.16万 - 项目类别:
Planning for a National Non-Communicable Disease Center of Research Excellence
规划国家非传染性疾病卓越研究中心
- 批准号:
9337384 - 财政年份:2016
- 资助金额:
$ 52.16万 - 项目类别:
Planning for a National Non-Communicable Disease Center of Research Excellence
规划国家非传染性疾病卓越研究中心
- 批准号:
9193832 - 财政年份:2016
- 资助金额:
$ 52.16万 - 项目类别:
Origin and Lineage of Differentiation of Kaposi's Sarcoma
卡波西肉瘤的起源和分化谱系
- 批准号:
8839925 - 财政年份:2015
- 资助金额:
$ 52.16万 - 项目类别:
HIV and substances of abuse influence exosomes and endothelial cell function
HIV 和滥用物质影响外泌体和内皮细胞功能
- 批准号:
9304176 - 财政年份:2015
- 资助金额:
$ 52.16万 - 项目类别: