Data Analysis Core

数据分析核心

• 批准号: 10118876
• 负责人: James Paul Carson
• 金额: $ 11.41万
• 依托单位: BATTELLE PACIFIC NORTHWEST LABORATORIES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10118876
• 关键词: 3-Dimensional; Anatomy; Atlases; Cells; Consensus; Data; Data Analyses; Data Collection; Data Set; Data Storage and Retrieval; Ensure; Environment; Equipment; FAIR principles; High Performance Computing; Human; Human BioMolecular Atlas Program; Human Resources; Image; Ingestion; Learning; Link; Maps; Metadata; Modality; Molecular; Ontology; Organ; Output; Pancreas; Positioning Attribute; Procedures; Process; Protocols documentation; Reproducibility; Resolution; Resources; Role; Secure; Signal Transduction; Systems Biology; Texas; Tissues; Universities; Work; austin; base; computerized data processing; data format; data ingestion; data integration; data quality; data sharing; experience; extracellular; interoperability; multiple omics; novel; open source; spatial relationship; tool

PROJECT ABSTRACT The Data Analysis Core (DAC) is responsible for all aspects of data and metadata management, processing, analysis, mapping, and sharing for this Tissue Mapping Center (TMC) and its Organ Specific Project (OSP) focused on the pancreas. The DAC will support the TMC in these activities by providing a protected environment for data storage and computation, and by developing robust reproducible, reusable, and scalable computational workflows thus enabling the integration of data types into 3D maps for the purpose of creating an interactive and queryable biomolecular human atlas. The DAC is an important part of the TMC in its objectives to produce and deliver to the HIVE extensive sets of high-resolution spatial mappings of molecular entities, using open formats, and within the context of the cellular and extracellular organization of the pancreas. Specifically, we will: (1) ingest and process TMC datasets; (2) analyze datasets in support of generating multiscale, multiparameter tissue maps; (3) construct 3D tissue maps to integrate datasets; and (4) coordinate planning with the HuBMAP Consortium.

项目摘要 数据分析核心（DAC）负责数据和元数据管理、处理 组织映射中心（TMC）及其器官特异性项目（OSP）的分析、映射和共享 专注于胰腺。发展援助委员会将通过提供受保护的 环境的数据存储和计算，并通过开发强大的可复制，可重用和可扩展的 计算工作流，从而能够将数据类型集成到3D地图中，以创建 一个交互式和可查询的生物分子人类图谱。DAC是TMC的重要组成部分， 目标是产生并向HIVE提供广泛的高分辨率分子空间映射集， 实体，使用开放格式，并在细胞和细胞外组织的背景下， 胰腺 具体来说，我们将：（1）摄取和处理TMC数据集;（2）分析数据集以支持生成 多尺度、多参数组织图;（3）构建3D组织图以整合数据集;以及（4）协调 与HuBMAP联盟合作。