Development of cannabinoid-opioid combination with opioid sparing and synergistic analgesic effects to prevent opioid use disorder and overdose.

开发具有阿片类药物节约和协同镇痛作用的大麻素-阿片类药物组合，以防止阿片类药物使用障碍和过量。

• 批准号: 10118287
• 负责人: Marisa Briones
• 金额: $ 5.5万
• 依托单位: BDH PHARMA, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2020-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10118287
• 关键词: Absence of pain sensation; Address; Advanced Development; Agonist; American; Analgesics; Anti Inflammatory Analgesics; Anxiety; Area; Buprenorphine; CYP3A4 gene; Cannabidiol; Cannabinoids; Cannabis sativa plant; Caregivers; Clinical; Clinical Trials; Data; Dependence; Development; Dosage Forms; Dose; Drug Interactions; Drug Kinetics; Epilepsy; FDA approved; Fentanyl; Formulation; Goals; Heroin; Human; In Vitro; Individual; Legal patent; Licensing; Mental Depression; Needs Assessment; Opiate Addiction; Opioid; Opioid Analgesics; Opioid agonist; Overdose; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Phase I Clinical Trials; Physical Dependence; Physicians; Prevention; Public Health; Rattus; Regimen; Regulatory Pathway; Reporting; Research Support; Respiration; Risk; Rodent; Rodent Model; Role; Safety; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Societies; Therapeutic; Toxicology; United States National Institutes of Health; Ventilatory Depression; Withdrawal; Withdrawal Symptom; addiction; chronic pain; commercialization; healing; improved; in vivo; medication safety; novel therapeutics; opioid abuse; opioid abuse prevention; opioid epidemic; opioid misuse; opioid overdose; opioid sparing; opioid use; opioid use disorder; opioid withdrawal; overdose death; overdose risk; phytocannabinoid; pre-clinical; preclinical study; prescription opioid; prevent; response; safety assessment; safety study; sedative

Project Summary/Abstract Approximately 2 million individuals in the US meet criteria for an opioid use disorder, with millions more reporting use or misuse of opioid pain relievers in the past month. Along with an increase in opioid use disorders, a rise in opioid-related overdose deaths has occurred in the last decade reaching a public health crisis. Chronic pain and opioid abuse are more prevalent than before constituting a public health crisis and exacting a heavy toll on patients, caregivers, physicians and society. There is a current therapeutic challenge for managing opioid use disorder, opioid withdrawal symptoms, chronic pain, and/or associated anxiety and depression. A severe need remains for alternative and safe therapeutic regimens that properly treat these conditions. We propose to develop a cannabinoid-opioid combination with opioid sparing and synergistic analgesic effects to prevent opioid use disorder and overdose​, ​addressing the current national opioid crisis. BDH Pharma, LLC recently completed a proof-of-concept preclinical study of a cannabinoid-opioid combination that demonstrated opioid sparing and synergistic analgesic effects, with the combination providing greater analgesia in a rodent model of chronic pain than a standard dose of the opioid alone. These results suggest that a fixed-dose combination (FDC) of the cannabinoid-opioid may have improved analgesia with lower opioid doses and thereby lower the risk of dependence, withdrawal, diversion, abuse, and overdose. This proposal will continue the development of the FDC by completing a preclinical pharmacokinetic and ​in vivo ​safety study to determine if co-administration alters the pharmacokinetics and/or respiratory depression related to either compound in rodents. Upon completion of the proposed Phase 1 aims, we will submit a Phase 2 SBIR application to complete any additional preclinical studies required by the FDA, to complete formulation studies​, and to support the manufacturing under GMP conditions of the final clinical dosage form that will be used in a subsequent phase 1 clinical trial of the FDC in humans.

项目总结/文摘