Cellular and Molecular Imaging Core

细胞和分子成像核心

• 批准号: 10077861
• 负责人: REBECCA LUCY HULL-MEICHLE
• 金额: $ 9.87万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-10 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10077861
• 关键词: Achievement; Applications Grants; Area; Collaborations; Comparative Pathology; Computer software; Core Facility; Data; Diabetes Mellitus; Disease; Ensure; Equipment; Fluorescence; Fostering; Funding; Goals; Histocytochemistry; Human Resources; Image; Image Analysis; Imaging Techniques; Immunohistochemistry; Individual; Institution; Investigation; Knowledge; Leadership; Manuscripts; Methodology; Methods; Microscopy; Microtomy; Morphology; Obesity; Pathologist; Peer Review Grants; Process; Productivity; Protocols documentation; Publishing; Quality Control; Quantitative Microscopy; Reagent; Reproducibility; Research; Research Design; Research Personnel; Scanning; Services; Techniques; Tissue imaging; Tissues; Training; Universities; Washington; Work; base; body system; cellular imaging; comparative; cost effective; diabetes pathogenesis; experimental study; flexibility; high standard; imaging modality; innovation; instrumentation; laser capture microdissection; microscopic imaging; molecular imaging; preclinical study; response; tissue processing

The Cellular and Molecular Imaging Core, which had its origin in 1977, facilitates the outstanding and innovative research of Diabetes Research Center affiliates in the Seattle area by keeping pace with and pioneering new methodological and technical advances in histochemistry, microscopic imaging and image analysis. In the next funding cycle the CMIC will continue to promote the research of these investigators during the next funding cycle by providing: (1) Quantitative assessment of immunohistochemistry and morphological changes in tissues; (2) Access to state-of-the-art imaging instrumentation, in a cost-effective manner; (3) Expert diabetes-related technical and scientific support, including design of research protocols and interpretation of results; (4) Access to comparative pathologists, to assist with experimental and/or preclinical studies; and (5) Hands-on and didactic training to affiliates, their trainees and personnel with routine and highly specialized morphological, histochemical and imaging techniques. Through all of these services, the Cellular and Molecular Imaging Core places a great deal of emphasis on ensuring high standards of rigor and reproducibility for studies undertaken in the Core. This includes, but is not limited to, rigorous quality control for reagents, expert review of protocols and ensuring appropriate and adequate use of positive and negative controls. By achieving these goals, the Cellular and Molecular Imaging Core will support the scientific investigation of affiliate investigators who will use the core to further our understanding of diabetes, obesity and related disorders.

细胞和分子成像核心，起源于1977年，促进了杰出的和 西雅图地区糖尿病研究中心分支机构的创新研究 在组织化学、显微成像和成像方面开创新的方法和技术进步 分析。在下一个资助周期中，CMIC将继续促进这些研究人员的研究 下一个供资周期提供：(1)免疫组织化学和形态学的定量评估 组织的变化；(2)以具有成本效益的方式获得最先进的成像仪器；(3) 与糖尿病相关的专家技术和科学支持，包括设计研究方案和 对结果的解释；(4)接触比较病理学家，协助进行实验和/或临床前工作 学习；以及(5)对附属公司、其受训人员和人员进行常规和高度的动手和说教培训 专门的形态、组织化学和成像技术。通过所有这些服务，蜂窝 和分子成像核心非常强调确保高标准的严格性和 在核心进行的研究的重现性。这包括但不限于，严格的质量控制 试剂、方案的专家审查以及确保适当和充分地使用阳性和阴性 控制。通过实现这些目标，细胞和分子成像核心将支持科学 对附属调查人员的调查，他们将使用核心来加深我们对糖尿病、肥胖症和 相关的障碍。