CELLULAR AND MOLECULAR IMAGING CORE

细胞和分子成像核心，其中有其起源于1977年，促进了杰出的， 糖尿病研究中心附属机构在西雅图地区的创新研究， 在（免疫）组织化学、显微成像和 图像分析在下一个资助周期中，CMIC将继续推动这些研究人员的研究 通过提供：（1）专家糖尿病相关的技术和科学支持，包括研究咨询 设计，使用适当的控制，并解释结果;（2）严格的定量评估 免疫组织化学和组织形态学变化;（3）以成本效益高的方式获得最新技术 （4）对附属机构、受训人员和具有以下能力的人员进行实践和教学培训： 常规和高度专业化的形态学，组织化学和成像技术;（5）获得临床 和比较病理学家，以协助实验和/或临床前研究。通过所有这些 核心领导层和工作人员分享他们在糖尿病相关组织工作方面的专业知识， 解释细胞组成/形态的疾病相关变化。细胞和分子成像 Core非常重视确保研究的严格性和可重复性的高标准 在核心中进行。这包括但不限于对试剂进行严格的质量控制， 确保适当和充分使用阳性和阴性对照。核心报价 多种先进的自动化免疫组织化学服务，包括常规、共聚焦和超级免疫组织化学， 分辨率显微镜、激光捕获显微切割和自动/AI图像分析。通过实现这些 目标，细胞和分子成像核心将继续支持附属公司的科学研究 研究人员将使用核心来进一步了解糖尿病和相关疾病。

The Cellular and Molecular Imaging Core, which had its origin in 1977, facilitates the outstanding and innovative research of Diabetes Research Center affiliates in the Seattle area by keeping pace with and pioneering new methodological and technical advances in (immuno)histochemistry, microscopic imaging and image analysis. In the next funding cycle the CMIC will continue to promote the research of these investigators by providing: (1) Expert diabetes-related technical and scientific support, including consultation for study design, use of appropriate controls, and interpretation of results; (2) Rigorous quantitative assessment of immunohistochemistry and morphological changes in tissues; (3) Cost-effective access to state-of-the-art imaging instrumentation; (4) Hands-on and didactic training to affiliates, their trainees, and personnel with routine and highly specialized morphological, histochemical, and imaging techniques; and (5) Access to clinical and comparative pathologists to assist with experimental and/or preclinical studies. Through all of these services, Core leadership and staff share their deep expertise in working with diabetes-relevant tissues and in interpreting disease-related changes in cellular composition/morphology. The Cellular and Molecular Imaging Core places a great deal of emphasis on ensuring high standards of rigor and reproducibility for studies undertaken in the Core. This includes, but is not limited to, rigorous quality control for reagents, expert review of protocols and ensuring appropriate and adequate use of positive and negative controls. The Core offers multiple state-of-the-art services for automated immunohistochemistry, conventional, confocal and super- resolution microscopy, laser capture microdissection and automated/AI image analysis. By achieving these goals, the Cellular and Molecular Imaging Core will continue to support the scientific investigation of affiliate investigators who will use the Core to further our understanding of diabetes and related disorders.