Utah Center for Clinical and Translational Science

联系PD/PI：Dere，Willard H. 摘要-总体 犹他州大学临床和转化科学中心（CCTS）是 在Intermountain West进行翻译研究。CCTS已成为将 犹他州大学及其合作伙伴成为一个充满活力的研究企业，推进两个临床项目 和转化研究的科学。为了实现这些目标，CCTS由共同主要研究者领导 Drs. Dere和Hess在机构领导层中处于有利地位，并得到各种 补充CCTS活动的机构倡议和资源。联合PI由一个 由经验丰富的地方、区域和国家领导人组成的综合小组，并由一个全面的 在犹他州大学及其合作伙伴内部锚定CCTS的监督结构。我们的建议是 我们在实力领域取得的成就奠定了坚实的基础，这些领域包括但不限于： 这导致了许多致病基因的发现和各种软件的开发 全球计算基因组学中使用的平台;我们的社区外展工作， 主要领导人的州和全国性举措;我们开发的统计方法和软件， 替代标志物;以及我们在临床试验方面的丰富经验，包括传统的随机和 务实，多中心的合作网络，继续研究各种特殊人群 最近NCATS生命周期倡议确定的。通过支持各级成功的受训人员， 为他们的生产性职业生涯做好准备，我们正在建立一支能够利用我们广泛的 推动国家CTSA目标的基础设施。CCTS活动的广度使其能够解决 通过提供及时的资源、咨询和服务，解决既定和新出现的体制问题。我们看起来 期待通过一套全面的解决重大公共卫生和转化研究问题， 服务，以及奖励团队科学和高质量研究的文化，以更好地确保 研究再现性。我们通过四个具体目标来实现我们的目标：（1）催化临床和 翻译研究作为CTSA中心的山间西部;（2）推进和完善教育 最大化不同利益相关者之间的合作和培训价值的环境;（3）整合 不同的合作伙伴，在翻译领域的研究工作中进行有意义的合作;（4） 促进高效和有效的数据收集、分析和共享，利用创新的信息学- 基于解决方案。 项目摘要/摘要第282页 联系PD/PI：Dere，Willard H.

Contact PD/PI: Dere, Willard H. ABSTRACT - OVERALL The University of Utah Center for Clinical and Translational Science (CCTS) serves as the central locus of translational research in the Intermountain West. The CCTS has become the center for combining the efforts of the University of Utah and its partners into a vibrant research enterprise which advances both clinical projects and the science of translational research. To realize these goals, the CCTS is led by Co-Principal Investigators Drs. Dere and Hess, who are well positioned within institutional leadership and are supported by a variety of institutional initiatives and resources that complement the CCTS activities. The Co-PIs are supported by an integrated group of experienced local, regional, and national leaders and are guided by a comprehensive oversight structure that anchors the CCTS within the University of Utah and its partners. Our proposal builds on a firm foundation of achievements in areas of strength which include but are not limited to: our genetics programs, which has led to discoveries of numerous disease-causing genes and to a variety of software platforms that are used in computational genomics globally; our community-outreach efforts, highlighted by state- and nationwide initiatives by key leaders; our statistical methods and software developed to evaluate surrogate markers; and our substantive experiences in clinical trials, both traditional randomized and pragmatic, and multi-center collaboration networks, which continue to study a variety of special populations identified by the recent NCATS Lifespan initiatives. By supporting successful trainees at all levels and preparing them for productive careers, we are building a diverse workforce able to use our extensive infrastructure to advance national CTSA goals. The breadth of the CCTS activities allows it to address established and emerging institutional issues by providing timely resources, advice, and services. We look forward to addressing major public health and translational research issues through a comprehensive suite of services, as well as a culture that prizes team science and high quality research in order to better ensure research reproducibility. We seek to achieve our goals through four specific aims: (1) Catalyze clinical and translational research as the CTSA hub for the Intermountain West; (2) Advance and refine an educational environment that maximizes the value of collaboration and training among various stakeholders; (3) Integrate diverse partners for meaningful collaborations in research endeavors across the translational spectrum; (4) Promote efficient and effective data collection, analyses, and sharing that leverages innovative informatics- based solutions. Project Summary/Abstract Page 282 Contact PD/PI: Dere, Willard H.