Novel strategies for storage and recovery of cadaveric bone marrow stem cells
尸体骨髓干细胞储存和恢复的新策略
基本信息
- 批准号:10116454
- 负责人:
- 金额:$ 68.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-03-15 至 2023-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptionAllograftingAspirate substanceB-LymphocytesBasic ScienceBiological Specimen BanksBlood BanksBlood VesselsBone BanksBone MarrowBone Marrow AspirationBone Marrow CellsBone Marrow Stem CellBone Marrow TransplantationCadaverCell SeparationCellsCessation of lifeChildClinicalClinical ResearchClinical TrialsCommunicable DiseasesComplementComplexCost SavingsCryopreservationCryopreserved CellDendritic CellsDimethyl SulfoxideDiseaseEcosystemGenerationsGenetic VariationGiftsHLA AntigensHealthHematopoieticHematopoietic Stem Cell TransplantationHematopoietic stem cellsHospitalsIn SituIndustrializationInfrastructureInjuryInvestigationLifeLiving DonorsManualsMarrowMesenchymal Stem CellsMethodsMinorityModelingMusNatural Killer CellsOrganOrgan DonorOrgan ProcurementsPatientsPhasePhysiciansProceduresProcessProductionRampRecoveryRegistriesReproducibility of ResultsResearchResearch PersonnelResourcesSavingsSourceSpecimenSterilitySystemT-LymphocyteTechnologyTherapeuticTherapeutic Human ExperimentationTimeTissue DonorsTissue EngineeringTissuesUmbilical Cord BloodUnited States Health Resources and Services AdministrationVacuumWomanWorkbonecell typecostgene therapyhealth disparityhuman leukocyte antigen testingimprovedinnovationinterestnovelnovel strategiesperipheral bloodphase 2 studyprogenitorprotective effectstemstem cellstrial comparingvertebra body
项目摘要
ABSTRACT
Bone marrow represents a rich source of diverse stem, progenitor and other cells of clinical and research interest
including hematopoietic stem cells (HSC) and mesenchymal stem cells (MSC), dendritic cells, T-cells, natural
killer (NK) cells, B-cells and others. Currently, these cells are only recovered from living donors through bone
marrow aspiration or peripheral blood mobilization. Ossium Health is developing the first clinical and research
bank of bone marrow derived cells from deceased organ and tissue donors. While the concept of utilizing this
resource for bone marrow cells was first described over 60 years ago, the ability to recover viable material
efficiently and the infrastructure necessary to achieve this at even a modest scale simply has not existed. Ossium
Health has overcome this by establishing a robust ecosystem comprised of a world-class tissue processor (and
Phase III partner), major organ procurement agencies and innovation to, for the first time, allow recovery and
banking of this plentiful source of potentially life-saving cells. However, for this bank to reach its full potential,
further efficiencies must be advanced and implemented. This Phase II study aims to develop “smart baking”
innovations by optimizing methods of cryopreserving intact marrow in situ within whole bones to allow time for
infectious disease, sterility and HLA testing prior to investing in fully processing donor bones to isolate cellular
components. This innovative work will also provide early guidance towards cryopreservation of more complex
tissues such as vascular composite allografts (VCA). The resulting technology from this study may increase
efficiency by as much as 80% - drastically reducing cost and allowing more readily available and less expensive
clinical grade and high-quality research material to be available to meet the growing demands of gene therapy,
tissue engineering and basic science investigation.
摘要
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Identification and characterization of a large source of primary mesenchymal stem cells tightly adhered to bone surfaces of human vertebral body marrow cavities.
- DOI:10.1016/j.jcyt.2020.07.003
- 发表时间:2020-11
- 期刊:
- 影响因子:4.5
- 作者:Johnstone BH;Miller HM;Beck MR;Gu D;Thirumala S;LaFontaine M;Brandacher G;Woods EJ
- 通讯作者:Woods EJ
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{{ truncateString('ERIK J. WOODS', 18)}}的其他基金
Novel strategies for storage and recovery of cadaveric bone marrow stem cells
尸体骨髓干细胞储存和恢复的新策略
- 批准号:
9910145 - 财政年份:2018
- 资助金额:
$ 68.73万 - 项目类别:
OssioStem-matched multipotent MSC (M3): banked, low passage bone marrow MSC for treatment of hematopoietic acute radiation syndrome.
OssioStem 匹配的多能 MSC (M3):库存的低通道骨髓 MSC,用于治疗造血急性放射综合征。
- 批准号:
9913377 - 财政年份:2018
- 资助金额:
$ 68.73万 - 项目类别:
OssioStem-matched multipotent MSC (M3): banked, low passage bone marrow MSC for treatment of hematopoietic acute radiation syndrome.
OssioStem 匹配的多能 MSC (M3):库存的低通道骨髓 MSC,用于治疗造血急性放射综合征。
- 批准号:
10392485 - 财政年份:2018
- 资助金额:
$ 68.73万 - 项目类别:
OssioStem-matched multipotent MSC (M3): banked, low passage bone marrow MSC for treatment of hematopoietic acute radiation syndrome.
OssioStem 匹配的多能 MSC (M3):库存的低通道骨髓 MSC,用于治疗造血急性放射综合征。
- 批准号:
10271661 - 财政年份:2018
- 资助金额:
$ 68.73万 - 项目类别:
Novel Disaccharide-Based Cryopreservation Approach for Stable, -80°C Storage of Stem Cells
基于二糖的新型冷冻保存方法,用于-80℃稳定储存干细胞
- 批准号:
9410055 - 财政年份:2017
- 资助金额:
$ 68.73万 - 项目类别:
Optimizing Industrial-Scale GMP Processes for Recovering and Banking Deceased Donor Bone Marrow
优化工业规模 GMP 流程以回收和储存已故捐献者骨髓
- 批准号:
9926831 - 财政年份:2017
- 资助金额:
$ 68.73万 - 项目类别:
A Novel, Inexpensive Cryopreservation System for Stable -80 degree C Storage of A
一种新型、廉价的冷冻保存系统,可在 -80 摄氏度下稳定储存 A
- 批准号:
8199764 - 财政年份:2011
- 资助金额:
$ 68.73万 - 项目类别:
Therapeutic Angiogenesis by Universal Donor Endometrial Regenerative Cells
通用供体子宫内膜再生细胞的治疗性血管生成
- 批准号:
7804372 - 财政年份:2010
- 资助金额:
$ 68.73万 - 项目类别:
A Novel Device Design for Sperm Cryopreservation
精子冷冻保存的新型装置设计
- 批准号:
7665250 - 财政年份:2009
- 资助金额:
$ 68.73万 - 项目类别:
A NOVEL APPROACH TO GMP PRODUCTION, CRYOPRESERVATION AND DISTRIBUTION OF TOOTH DE
一种 GMP 生产、冷冻保存和分配牙齿的新方法
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7935375 - 财政年份:2009
- 资助金额:
$ 68.73万 - 项目类别:
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