Development Core

摘要 发展核心的目标是加强研究培训、领导能力和专业能力 为有兴趣开展研究的肯尼亚和乌干达初级卫生保健专业人员建立网络 有关艾滋病毒相关恶性肿瘤的问题。本次U54续签申请继续关注 加强与人乳头瘤病毒（HPV）和艾滋病毒感染者宫颈癌相关的研究能力 东非妇女。在肯尼亚，协调将通过提供医疗保健的学术模式进行 (AMPATH) 合作伙伴关系，由北美学术医学院的协作网络组成， 莫伊大学和莫伊教学和转诊医院。在乌干达，将与国际组织进行协调 评估艾滋病流行病学数据库 (IeDEA) 与麦克雷雷大学合作，培育了 通过参与 Afya Bora 联盟进行合作研究指导；跨专业计划 培养全球卫生领导力。该核心汇集了我们的集体专业知识，以快速推进研究 能力重点关注与艾滋病毒相关的恶性肿瘤，并帮助培养下一代肯尼亚和 乌干达研究领导者通过以下具体目标： 具体目标 1：利用当前和未来的 U54 项目队列数据来增强转化 以及东非基于人口的艾滋病毒/艾滋病和艾滋病毒相关恶性肿瘤的同行评审研究。 通过竞争性申请流程，我们每年将奖励 4-6 个试点项目。每位学员将 与一位主要科学导师相匹配，分配一位指定的现场导师，并由研究人员监督 咨询委员会（RAC）由具有相关专业技术知识的团队成员组成。 指导将包括研究方法、实施、资助写作技巧、预算和财务 管理。受训者应提交第一作者出版物和外部资助申请。 具体目标 2：建立指导和领导力发展计划，以促进以下领域的研究： 肯尼亚和乌干达医疗保健专业人员与艾滋病毒相关的恶性肿瘤。有独特的技能 由研究人员在其研究人群感染艾滋病毒和/或患有慢性癌症时开发 疾病通常与不良预后和长期护理有关。培训模块和专业 Afya Bora 联盟的开发工具将进行修改以应对这些挑战。系统化 评估将为可持续指导和领导力发展计划的制定提供信息。 具体目标 3：建立可持续的专业网络和合作研究机制 将肯尼亚和乌干达的医疗保健专业人员和学员团结起来。每月研讨会将加强 这一新建立的合作展示了相互关联和互补的研究项目。初级 学员将有机会申请旅行奖，以便他们可以出席科学会议， 从而扩大他们的专业网络并获得其领域的认可。

ABSTRACT The goal of the Developmental Core is to enhance the research training, leadership capacity and professional networking for junior Kenyan and Ugandan health care professionals who are interested in addressing research questions regarding HIV-associated malignancies. This U54 renewal application continues to focus on strengthening research capacity related to human papillomavirus (HPV) and cervical cancer in HIV-infected women of East Africa. In Kenya, coordination will be through the Academic Model Providing Access to Healthcare (AMPATH) partnership which consists of a collaborative network of North American academic medical schools, Moi University and Moi Teaching and Referral Hospital. In Uganda, coordination will be with the International Epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration and Makerere University that has fostered collaborative research mentoring through participation in the Afya Bora Consortium; an interprofessional program fostering global health leadership. This Core brings together our collective expertise to rapidly advance research capacity focused on HIV-associated malignancies and to help develop the next generation of Kenyan and Ugandan research leaders through the following Specific Aims: Specific Aim 1: To leverage the current and future U54 Project cohort data to enhance the translational and population-based HIV/AIDS and HIV-Associated Malignancy peer-reviewed research in East Africa. Through a competitive application process, we will award 4-6 pilot projects each year. Each mentee will be matched to a primary scientific mentor, assigned a designated site mentor, and supervised by a Research Advisory Committee (RAC) consisting of team members with relevant professional and technical expertise. Mentoring will include research methodologies, implementation, grant writing skills, budgeting and financial management. Mentees are expected to submit first-author publications and an external grant application. Specific Aim 2: To establish a mentorship and leadership development program to promote research in HIV-associated malignancies for Kenyan and Ugandan healthcare professionals. There are unique skills developed by researchers when their study populations are HIV-infected and/or have cancer, which are chronic diseases often associated with poor prognoses and long-term care. Training modules and professional development tools from the Afya Bora Consortium will be modified to address these challenges. Systematic evaluations will inform the development of sustainable mentorship and leadership development programs. Specific Aim 3: To develop sustainable professional networking and collaborative research mechanisms that unite Kenyan and Ugandan healthcare professionals and trainees. Monthly seminars will strengthen this newly established collaboration and showcase inter-related and complementary research projects. Junior trainees will have an opportunity to apply for Travel Awards so they may present at scientific conferences, thereby expanding their professional network and gaining recognition in their field.