Elucidating the Necessary Components and Mechanisms of Cognitive Training

阐明认知训练的必要组成部分和机制

• 批准号: 10319817
• 负责人: Lesley A Ross
• 金额: $ 80.26万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-15 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10319817
• 关键词: Elucidating; Necessary; Components; Mechanisms; Cognitive

Project Title: Elucidating the Necessary Components and Mechanisms of Cognitive Training Project Dates: June 1, 2020-Mary 31, 2021 Project Number: U01AG062370 The continued goal of this project (grant title: Elucidating the Necessary Components and Mechanisms of Cognitive Training, U01AG062370) and associated supplement is to develop and evaluate the protocol to examine behavioral and neural mechanisms underlying multiple cognitive training programs in older adults. Dr. Ross relocated to Clemson University and seeks approval to move the grant to Clemson with subcontracts returned to Penn State, Einstein, and UAB to complete the work as originally planned. The overall goal and aims of the project are the same with changes outlined below primarily due to COVID-19. Changes due to PI move to Clemson: None. Dr. Ross has attained an Endowed Chair position in Aging and Cognition. This position includes no teaching responsibilities for two years which allows her to focus on research. Additionally, the Dr. Ross will maintain a faculty affiliate position at Penn State ensuring maintained access to Penn State systems. Dr. Ross holds several standing meetings with study staff and coinvestigators via zoom to ensure clear communication. These included weekly lab meetings to review study progress and weekly joint staff meetings with co- investigators and staff regarding any project difficulties. Additionally, all staff meet individually with Dr. Ross every other week and with the Center for Healthy Aging’s administrative leader monthly to address study or personnel issues. Dr. Sliwinski (mPI) will continue to oversee the Penn State subcontract as site PI. Given these multiple lines of communication which are already being implemented, Dr. Ross will be able to oversee the study from Clemson University. Changes due to COVID-19: The original project involved four in-person data collection visits and two additional in-person visits for the MRI subsample. Due to COVID-19, we redesigned all study materials and re-budgeted for additional equipment to allow us to collect all data remotely. In order facilitate the project moving forward, especially given concerns about possible additional waves of COVID in the winter of 2020-2021, we are moving to remote data collection. This decision was reached in consultation, and with approval, by NIA. The changes will allow us to collect cognitive, psychosocial, everyday functioning and self-reported sensory functioning using study-provided laptops at baseline, posttest, and follow-up. The smartphone data collection process has not changed and still includes cognitive and psychosocial measures administered daily throughout the study period. We are using the NIA-funded M2C2 mobile phone platform for daily assessments (Ambulatory Methods for Measuring Cognitive Change; U2C AG060408) which has been piloted using multiple phones over the last eight months. We have also partnered with established online assessment and training companies (Posit Science, TestMyBrain, and iFunction) to include established remote data collection assessments as well as newer ones developed or adapted for the purpose of this study (DECA, ANT). This provides significant overlap across new and established assessments in case there are technical difficulties with the newer remote data collection. Other changes: Given the complexity of remote data collection, we have included Dr. Christine Phillips as a Co-Investigator on the project. Dr. Phillips is a research assistant professor at Clemson and has worked with Dr. Ross for over 6 years. She will assist Dr. Ross with overseeing all aspects of the study.

项目名称：阐明认知训练的必要组成部分和机制 项目日期：2020年6月1日-2021年玛丽31日 项目编号：U 01 AG 062370 本项目的持续目标（资助名称：阐明生物学的必要组成部分和机制）是： 认知训练，U 01 AG 062370）和相关补充，旨在制定和评价方案， 研究老年人多种认知训练计划的行为和神经机制。博士 罗斯搬迁到克莱姆森大学，并寻求批准将赠款转移到克莱姆森与分包合同 回到宾夕法尼亚州立大学，爱因斯坦和UAB完成工作，按原计划。总体目标和 该项目的目标是相同的，但下文概述的变化主要是由于COVID-19。 由于PI移至克莱姆森而进行的变更： 没有。罗斯已获得在老化和认知赋予椅子的位置。该职位不包括 两年的教学职责，使她能够专注于研究。此外，罗斯博士将 在宾夕法尼亚州立大学保持教职员工的地位，确保保持对宾夕法尼亚州立大学系统的访问。罗斯医生 通过zoom与研究工作人员和合作研究者举行多次常务会议，以确保清晰的沟通。 其中包括每周一次的实验室会议，以审查研究进展，以及每周一次的联合工作人员会议， 调查人员和工作人员对任何项目的困难。此外，所有工作人员单独会见罗斯博士 每隔一周，每月与健康老龄化中心的行政领导，以解决研究或 人事问题。Sliwinski博士（mPI）将继续监督宾夕法尼亚州立大学的研究中心PI。给定 这些已经实施的多条通信线路，罗斯博士将能够监督 这项研究来自克莱姆森大学。 COVID-19导致的变化： 最初的项目涉及四次亲自数据收集访问和两次额外的MRI亲自访问 子样本由于COVID-19，我们重新设计了所有学习材料，并重新预算了额外的设备， 允许我们远程收集所有数据。为了促进项目的进展，特别是考虑到 鉴于2020-2021年冬季可能出现新冠疫情，我们正转向远程数据收集。 这一决定是经NIA协商并批准后做出的。这些变化将使我们能够收集 认知、社会心理、日常功能和自我报告的感觉功能，使用研究提供的 在基线、后测和随访时使用笔记本电脑。智能手机数据收集过程没有改变， 包括在整个研究期间每天给予的认知和心理社会测量。我们正在使用 NIA资助的M2 C2移动的电话平台，用于日常评估（测量的流动方法 认知变化; U2 C AG 060408），在过去的八个月里已经使用多部手机进行了试点。 我们还与成熟的在线评估和培训公司（Posit Science， TestMyBrain和iFunction），以包括已建立的远程数据收集评估以及更新的评估 为本研究的目的而开发或改编（DECA、ANT）。这在新的 以及在较新的远程数据收集出现技术困难时进行的既定评估。 其他变更： 鉴于远程数据收集的复杂性，我们邀请了克莉丝汀菲利普斯博士作为合作研究者， 该项目菲利普斯博士是克莱姆森的研究助理教授，与罗斯博士合作超过6年。 年她将协助Ross博士监督研究的各个方面。