Critical Analysis of a Rapid 4-compartment Model in Hispanic Adults:Effect of Age and Level of Body Fatness

西班牙裔成人快速四室模型的批判性分析：年龄和体脂水平的影响

• 批准号: 10088593
• 负责人: Brett Stephen Nickerson
• 金额: $ 25.03万
• 依托单位: TEXAS A&M INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-12 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10088593
• 关键词: Adult; Age; Age Distribution; Aging; Air; Award; Body Composition; Body Water; Body fat; Body mass index; Bone Mineral Contents; Cadaver; Characteristics; Clinical; Deuterium Oxide; Dual-Energy X-Ray Absorptiometry; Ensure; Equation; Evaluation; Exercise Physiology; Fatty acid glycerol esters; Hispanics; Hour; Individual; International; Knowledge; Laboratories; Measurement; Medical; Methods; Minerals; Mission; Modeling; Monitor; Not Hispanic or Latino; Obesity; Participant; Pilot Projects; Plethysmography; Population; Reference Values; Research; Research Personnel; Residual state; Sampling; Testing; Texas; Thinness; Time; United States National Institutes of Health; Universities; Variant; Visit; Weight; Woman; age effect; body volume; bone; density; improved; lifestyle intervention; men; middle age; obesity prevention; profession allied to medicine; recruit; response; sex

ABSTRACT In response to PAR-16-439, Support of Competitive Research (SCORE) Pilot Project Award (SC1), the PI is proposing a study that seeks to systematically evaluate a rapid 4-compartment (4C) model in a diverse sample of Hispanic adults. Testing will consist of one visit to the Exercise Physiology Laboratory at Texas A&M International University. The PI will recruit Hispanic men (n = 150) and women (n = 150) ages 18-79 years in Laredo Texas for this study. Participants will be block recruited to ensure equal distribution of age, sex, and BMI groups. A criterion 4C model will be determined using deuterium oxide for total body water (TBW), dual energy X-ray absorptiometry (DXA) for bone mineral content (BMC), and underwater weighing for body volume (BV). A rapid 4C model will be determined using DXA for BV and BMC and bioimpedance analysis (BIA) for TBW. The DXA- derived BV equation recently developed by the PI (1) in a group of young Hispanic adults (18-45 years) will be utilized to compute BV for the rapid 4C model. Validity will be established by comparing the %Fat, fat mass (FM), and fat-free mass (FFM) of the rapid 4C model against the criterion 4C model. The FFM density, (DFFM), bone mineral (MoFFM), total body water (TBWFFM), and residual (RFFM) will also be calculated in the rapid and criterion 4C model and compared against the cadaver reference values of Brozek et al. (2). The PI recently revealed that the FFM characteristics of young- and middle-aged Hispanic adults (18-55 years) significantly differs from non-Hispanic Whites and cadaver reference values of Brozek et al. (2). This is a significant finding since the cadaver reference values of Brozek et al. (2) are employed in stand-alone methods such as BIA. Nonetheless, further evaluations need to establish whether variations in FFM characteristics exist among Hispanic adults who vary in age and level of body fatness. Collectively, findings from the proposed study will help establish whether a rapid 4C model can be used in a diverse sample of Hispanic adults and whether the assumptions employed in stand-alone assessments such as BIA (73% TBWFFM) are violated.

摘要 为了回应PAR-16-439，竞争研究支持(得分)试点项目奖(SC1)，PI是 提出了一项研究，试图在不同的样本中系统地评估快速四室(4C)模型 西班牙裔成年人。测试将包括一次参观德克萨斯A&M的运动生理学实验室 国际大学。年，PI将招募年龄在18-79岁的西班牙裔男子(n=150)和妇女(n=150)。 德克萨斯州的拉雷多进行了这项研究。参与者将被整体招募，以确保年龄、性别和BMI的平等分布 组。 标准的4C模型将使用双能X射线全身水(TBW)的氧化重氢来确定 骨密度(DXA)测定骨矿含量(BMC)，水下称量身体体积(BV)。一次快速的 BV和BMC的DXA和TBW的生物阻抗分析(BIA)将确定4C模型。DXA- PI(1)最近在一组年轻的西班牙裔成年人(18-45岁)中推导出的BV方程将是 用于计算快速4C模型的BV。效度将通过比较脂肪百分比、脂肪质量(Fm)、 以及快速4C模型相对于标准4C模型的脱脂质量(FFM)。 FFM密度(DFFM)、骨矿物质(MoFFM)、全身水分(TBWFFM)和残留物(RFFM)也将 在快速和标准4C模型中进行计算，并与Brozek et的身体参考值进行比较 艾尔(2)。PI最近揭示了中青年拉美裔成年人(18-55岁)的FFM特征 年)与非西班牙裔白人和Brozek等人的身体参考值有显著差异。(2)。这是一个 自Brozek等人的身体参考值以来的重大发现。(2)以独立方法使用 例如BIA。尽管如此，进一步的评估需要确定实况调查特征是否存在差异。 在年龄和体脂水平不同的西班牙裔成年人中。总而言之，拟议研究的结果 将有助于确定快速4C模式是否可以在不同的西班牙裔成年人样本中使用，以及 违反了独立评估中使用的假设，如BIA(73%TBWFFM)。