A Mixed Methods Study of Chronic Kidney Disease (CKD) Self-Management

慢性肾脏病 (CKD) 自我管理的混合方法研究

• 批准号: 10089437
• 负责人: Sarah Jeanne Schrauben
• 金额: $ 19.49万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-03 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10089437
• 关键词: Address; Adherence; Adoption; Affect; Age; Area; Award; Behavior; Biometry; Blood Glucose; Blood Pressure Monitors; Cardiovascular Diseases; Characteristics; Chronic Kidney Failure; Chronic Kidney Insufficiency; Clinical; Clinical Management; Clinical Practice Guideline; Clinical Trials; Clinical Trials Design; Cohort Studies; Data; Data Analyses; Development; Dialysis procedure; Disease; Disease Management; Disease Outcome; Disease Progression; Economic Burden; Education; End stage renal failure; Environment; Epidemic; Epidemiology; Evaluation; Feedback; Fellowship; Funding; Grant; Guidelines; Health; Health Technology; Health behavior; Hypertension; Individual; Intervention; Intervention Studies; Intervention Trial; Interview; Investigation; Kidney; Longevity; Master' s Degree; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methods; Nature; Obesity; Outcome; Participant; Patient Outcomes Assessments; Patient Preferences; Patients; Pennsylvania; Persons; Physical activity; Population; Positioning Attribute; Postdoctoral Fellow; Predictive Factor; Publishing; Recommendation; Research; Research Design; Research Methodology; Research Personnel; Research Priority; Risk; Science; Self Management; Statistical Data Interpretation; Structure; Syndrome; Technology; Testing; Time; Tobacco; Training; United States National Institutes of Health; Universities; Work; approach behavior; career; career development; clinical epidemiology; cohort; comorbidity; cost; cost effective; design; experience; feasibility trial; health economics; health literacy; healthy lifestyle; implementation science; improved; mHealth; multidisciplinary; novel strategies; patient engagement; patient oriented; patient oriented research; pilot trial; prevent; programs; prototype; psychosocial; recruit; self-management program; skills; theories; therapy design; therapy development; uptake; usability

Project summary In late 2019, COVID-19, a disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) emerged in Wuhan, China and has rapidly impacted almost all countries around the world. Officially declared a global pandemic by the WHO, COVID-19 is a worldwide emergency and by million United with directly , current in vitro model platforms are so distinct from human infection that they may not capture key components of viral infection or virus-host interactions. May 29, 2020, over 5.8 COVID-19 cases were reported with over 360,000 deaths globally. Although originating in China the States has emerged as an epicenter of this pandemic with over 1.75 million COVID-19 cases reported over 103,000 deaths. Unfortunately there is no vaccine that can prevent SARS-CoV-2 infection or robust activing antivirals that can mitigate infection or alter disease progression. Moreover Given this local, national, and global emergency our near-term goal is on the development of novel and robust experimental cell culture models, virological tools, and to identify novel therapeutics for SARS-CoV-2 treatment. Our long-term goal is to elucidate the complex interactions and mechanisms underlying SARS-CoV-2 infection and host response. Given that our institution has been at the center of the COVID-19 pandemic here in the U.S. we have generated a wide database of clinical data that has revealed that a high prevalence of initial COVID- 19 presentations are with GI manifestations with over one-half of patients noted to have biochemical evidence of liver injury at presentation. The impact of SARS-CoV-2 infection on hepatocellular and cholangiocyte function remains unclear. To address these knowledge gaps we have generated several novel technologies and have assembled a robust team with complimentary expertise in stem cell biology, tissue engineering and virology, chemical screening and stem cell biology, and in virology/BSL3 expertise. We aim to identify drug candidates that impact SARS-CoV-2 viral infection while we evaluate host-virus interactions. Our work is urgently needed given the impacts SARS-CoV-2 has had on our local, national, and global communities and its potential impact on millions of people who already, or will in the future will develop COVID19 infection by shedding light on mechanisms, molecular targets, and potential drugs that could lead directly to the development of new antiviral treatments and therapies.

项目摘要 2019年底，Covid-19，一种由严重急性呼吸系统疾病冠状病毒2引起的疾病（SARS- COV-2）出现在中国武汉，并迅速影响了世界上几乎所有国家。正式 WHO宣布为全球大流行，Covid-19是全球紧急事件，由 具有直接的当前体外模型平台的百万曼联与人类感染是如此不同，以至于它们可能无法捕获病毒感染或病毒宿主相互作用的关键组成部分。 据报道，2020年5月29日，据报道，超过5.8 covid-19案件在全球范围内有超过360,000人死亡。尽管起源于中国，但美国已经成为这一大流行的中心，有超过175万份的案件报告 超过103,000人死亡。不幸的是，没有疫苗可以防止SARS-COV-2感染或牢固 可以减轻感染或改变疾病进展的活动抗病毒药。而且 鉴于这种本地，国家和全球紧急情况，我们的近期目标是发展小说和健壮 实验细胞培养模型，病毒学工具，并确定用于SARS-COV-2治疗的新型治疗剂。 我们的长期目标是阐明SARS-COV-2感染的复杂相互作用和机制 和主机响应。鉴于我们的机构一直处于美国19日大流行的中心 我们已经生成了广泛的临床数据数据库，该数据库表明，初始covid的高流行率很高 19介绍的胃肠道表现，有超过一半的患者有生化证据 表现时肝损伤。 SARS-COV-2感染对肝细胞和胆管细胞的影响 功能尚不清楚。为了解决这些知识差距，我们产生了几种新型技术 并在干细胞生物学，组织工程和 病毒学，化学筛查和干细胞生物学以及病毒学/BSL3专业知识。我们旨在识别药物 当我们评估宿主病毒相互作用时，会影响SARS-COV-2病毒感染的候选人。 鉴于SARS-COV-2对我们的本地，国家和全球的影响，我们的工作迫切需要迫切需要 社区及其对数百万已经或将来的人的潜在影响将发展 通过阐明可能导致的机制，分子靶标和潜在药物，COVID19感染 直接发展新的抗病毒治疗和疗法。