Animal and plant proteins and glucose metabolism
动植物蛋白与糖代谢
基本信息
- 批准号:10089440
- 负责人:
- 金额:$ 56.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AcidsAcuteAdultAdverse effectsAliquotAmino AcidsAnimal StructuresAnimalsBiologicalBiopsyBlood GlucoseC-PeptideCell WallChronicComplexConsumptionDataDietDietary ComponentDietary InterventionDietary ProteinsDiseaseEdible PlantsFGF21 geneFabaceaeFoodFortified FoodFutureGTP-Binding ProteinsGlucagonGlucoseGlucose ClampGlucose Plasma ConcentrationGoalsHealthHepaticHormonesHumanHyperinsulinismImpairmentIndicanInfusion proceduresIngestionInsulinInsulin ResistanceIntervention TrialLeadLectin InhibitorLiverMeatMediatingMetabolicMetabolic dysfunctionMusMuscleNon-Insulin-Dependent Diabetes MellitusOralOutcomeParticipantPlant ProteinsPlantsPlasmaPopulation StudyProceduresProductionProtease InhibitorProteinsRandomizedRiskSourceStable Isotope LabelingSulfateTestingTracerUnited StatesValineVascular PlantVolatile Fatty AcidsWomanbaseblood glucose regulationdiabetes riskglucagon-like peptide 1glucose disposalglucose metabolismglucose productionimprovedinsulin secretioninsulin sensitivityinsulin signalingmenmicrobialobesity preventionprotein intakeprotein metabolismprotein metaboliteresponsestool sampletrend
项目摘要
Abstract
Nearly 65% of adults in the United States actively try to increase their protein intake by
consuming naturally protein-rich foods and foods and drinks fortified with protein isolates to
improve their health. However, data from recent population studies have shown high protein
consumption is associated with an increased risk of developing type 2 diabetes (T2D). This
adverse effect might be specific to the type of protein consumed because several studies have
found high animal protein, but not high plant protein, consumption was associated with
increased T2D risk. There is experimental evidence from studies conducted in people and in
mice to support a causal relationship between dietary protein intake and metabolic dysfunction.
However, the effect of chronic high protein intake on glucose homeostasis and the mechanisms
that cause protein-mediated metabolic dysfunction are not known. The reason(s) for the
differences in the metabolic effects observed between high animal protein and high plant protein
consumption are also not known, but could be due to differences in the amino acid composition
and structure of animal and plant proteins per se and/or their biological matrix, which includes
complex cell walls, lectins, and protease inhibitors in protein-rich plant foods, that can impair gut
microbial access to proteins and/or induce the microbial production of beneficial metabolites,
such as short-chain fatty acids. The goal of this proposal is to determine the effect of a high-
protein diet in which the increase in protein intake is derived from different sources (animal vs
plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity;
ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose,
glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic
dysfunction. Our overarching hypothesis is that diets enriched with either animal or plant protein
isolates, or animal protein-rich whole foods, but not plant protein-rich whole foods, cause
alterations in the plasma hormones and protein metabolites that can cause insulin resistance
and stimulate hepatic glucose production, thereby raising 24-h plasma glucose concentration.
摘要
近65%的美国成年人积极尝试通过增加蛋白质摄入量
食用天然富含蛋白质的食物和用分离蛋白强化的食物和饮料
改善他们的健康状况。然而,最近的人口研究数据显示,高蛋白
消费与罹患2型糖尿病(T2D)的风险增加有关。这
不良反应可能特定于摄入的蛋白质类型,因为几项研究已经
发现高动物蛋白,但不高植物蛋白,摄入与
T2D风险增加。在人类和人类中进行的研究有实验证据
小鼠支持饮食蛋白质摄入量和代谢功能障碍之间的因果关系。
然而,长期高蛋白摄入对血糖稳态的影响及其机制
导致蛋白质介导的代谢功能障碍的原因尚不清楚。原因(S)
高动物蛋白和高植物蛋白代谢效应的差异
消耗量也是未知的,但可能是由于氨基酸组成的差异
以及动植物蛋白本身和/或其生物基质的结构,包括
富含蛋白质的植物食品中可损害肠道的复杂细胞壁、凝集素和蛋白酶抑制剂
微生物获得蛋白质和/或诱导微生物产生有益代谢物,
比如短链脂肪酸。这项提案的目标是确定高-
蛋白质饮食中蛋白质摄入量的增加来自不同的来源(动物与
富含植物和蛋白质的全食与分离蛋白质)在:i)肝脏和肌肉对胰岛素的敏感性;
Ii)对一餐的代谢反应,以及iii)24小时血糖的血浆浓度分布,
糖调节激素和蛋白质衍生的代谢物据称能引起代谢
功能障碍。我们的主要假设是,富含动物或植物蛋白的饮食
分离物或富含动物蛋白的全食食品,但不是富含植物蛋白的全食食品,会引起
可导致胰岛素抵抗的血浆激素和蛋白质代谢产物的变化
并刺激肝脏葡萄糖生成,从而提高24小时血糖浓度。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Samuel Klein其他文献
Samuel Klein的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Samuel Klein', 18)}}的其他基金
Exosomes and insulin action in metabolically healthy and unhealthy obesity
外泌体和胰岛素在代谢健康和不健康肥胖中的作用
- 批准号:
10721302 - 财政年份:2023
- 资助金额:
$ 56.8万 - 项目类别:
Washington University Nutrition Obesity Research Center
华盛顿大学营养肥胖研究中心
- 批准号:
10160292 - 财政年份:2020
- 资助金额:
$ 56.8万 - 项目类别:
Metabolic Effects of Sleep Extension in People with Obesity
延长睡眠对肥胖者的代谢影响
- 批准号:
10435463 - 财政年份:2018
- 资助金额:
$ 56.8万 - 项目类别:
Metabolic Effects of Sleep Extension in People with Obesity
延长睡眠对肥胖者的代谢影响
- 批准号:
10201581 - 财政年份:2018
- 资助金额:
$ 56.8万 - 项目类别:
相似海外基金
Un/kindness, shame & resistance: the care of inpatients in NHS adult acute mental health units and how it might be improved
Un/善良,羞耻
- 批准号:
2885806 - 财政年份:2023
- 资助金额:
$ 56.8万 - 项目类别:
Studentship
Post-Acute Care Transitions for Older Adult Medicare Beneficiaries with Serious Mental Illness
患有严重精神疾病的老年医疗保险受益人的急性后护理过渡
- 批准号:
10772386 - 财政年份:2023
- 资助金额:
$ 56.8万 - 项目类别:
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
- 批准号:
474619 - 财政年份:2022
- 资助金额:
$ 56.8万 - 项目类别:
Operating Grants
Investigating the impact acute inhalation of cannabis with a high content of delta-9-tetrahydrocannabinol has on myelination and microglia in adult and aged mice
研究急性吸入高含量 delta-9-四氢大麻酚的大麻对成年和老年小鼠髓鞘形成和小胶质细胞的影响
- 批准号:
485965 - 财政年份:2022
- 资助金额:
$ 56.8万 - 项目类别:
Studentship Programs
Paving The Way to a Canadian Standard of Care with CAR-T Cellular Therapy: Phase II Trial of CD19 CAR-T for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia (CLIC-01A)
通过 CAR-T 细胞疗法为加拿大护理标准铺平道路:CD19 CAR-T 治疗复发/难治性成人急性淋巴细胞白血病的 II 期试验 (CLIC-01A)
- 批准号:
466358 - 财政年份:2022
- 资助金额:
$ 56.8万 - 项目类别:
Operating Grants
Metabolomics for prediction of cisplatin mediated acute kidney injury: a Canadian multi-centre adult and pediatric study
预测顺铂介导的急性肾损伤的代谢组学:加拿大多中心成人和儿童研究
- 批准号:
402040 - 财政年份:2019
- 资助金额:
$ 56.8万 - 项目类别:
Operating Grants
Study of pathogenic mechanism of age-dependent chromosome translocation in adult acute lymphoblastic leukemia
成人急性淋巴细胞白血病年龄依赖性染色体易位发病机制研究
- 批准号:
18K16103 - 财政年份:2018
- 资助金额:
$ 56.8万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Causal effect of time-varying driving pressures on mortality in mechanically ventilated, adult patients with acute respiratory distress syndrome
时变驱动压力对机械通气成年急性呼吸窘迫综合征患者死亡率的因果影响
- 批准号:
377313 - 财政年份:2017
- 资助金额:
$ 56.8万 - 项目类别:
Studentship Programs
Role of SETBP1 in adult Ph+ acute lymphoblastic leukemia
SETBP1 在成人 Ph 急性淋巴细胞白血病中的作用
- 批准号:
9315111 - 财政年份:2016
- 资助金额:
$ 56.8万 - 项目类别:
Acute Inhibition of Adult-born Granule Cells and its Effect on Antidepressant Act
成体颗粒细胞的急性抑制及其抗抑郁作用
- 批准号:
8734273 - 财政年份:2013
- 资助金额:
$ 56.8万 - 项目类别: