Signaling mechanisms and functions related to patho-physiology of vascular, lung and blood systems
与血管、肺和血液系统病理生理学相关的信号传导机制和功能
基本信息
- 批准号:10089468
- 负责人:
- 金额:$ 91.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-02-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:Adult Respiratory Distress SyndromeApplications GrantsBiochemicalBiologicalBloodBlood VesselsCRISPR/Cas technologyCell PolarityCell membraneCell-Matrix JunctionCellsChemicalsChemotactic FactorsDiseaseExocytosisFibroblastsFunctional disorderFundingFunding MechanismsG-Protein-Coupled ReceptorsGenomicsHeartIn VitroLaboratoriesLungMediatingMissionMolecularNADPH OxidasePathogenicityPathway interactionsPhysiologicalProcessProteomicsPulmonary FibrosisRNA InterferenceReadinessRegulationResearchResearch Project GrantsSignal PathwaySignal TransductionStructureSystemTechnologyTestingTherapeuticTransgenic OrganismsWnt proteinsbasefallsflexibilityfunctional genomicshigh rewardhigh riskin vivoinnovationinsightinterestmigrationnovelreceptorsuccesstherapeutic target
项目摘要
Project Summary:
My laboratory is interested in understanding molecular basis and functions for two signaling
pathways that use seven transmembrane receptors in their signaling transduction. One of the
pathways is mediated by G protein-coupled receptors, and the other is activated by Wnt
proteins. We have been using a combination of biochemical, molecular and cell biological,
transgenic, genomic, proteomic, structural and chemical biological approaches to discover novel
signaling mechanisms and investigate their functions in vitro and in vivo. In this R35 application,
I intend to streamline our current four research projects that are pertinent to NHBLI missions
under one funding mechanism. Two of the projects are current funded by NHBLI. These four
projects are: 1) To test the hypothesis that the initial break of the symmetry may arise from PM
PI4P polarization caused by plasma membrane deformation as the result of cell attachment.
Polarized PM PI4P defines the “uropod” and thus the initial cellular polarity, upon which further
polarization stimulated by chemoattractants is extended. 2) To investigate the sustained
signaling pathway for regulation of fibroblast migration and its therapeutic potential in treating
pulmonary fibrosis. 3) To Investigate the hypothesis that increased exocytosis is a pathogenic
basis for CCM disease. 4) To investigate MEKK3 as being a negative regulator of NADPH
oxidase 2 (NOD2) and potential therapeutic target for acute respiratory distress syndrome.
Each of the project is highly innovative and would exert a strong impact in their respective field.
In addition, we are generating the new leads coming from these high risk/high reward studies
that include functional genomic screens based on the CRISPR/Cas9 and RNAi technologies.
Thus, this R35 mechanism would not only allow streamlining our grant application and
management so that we can better focus our effort on research, but also afford us the flexibility
to fully and efficiently pursue the new leads coming from these high risk/high reward studies.
Our track record strongly indicates our readiness, capability, and success to pursue subjects
that we deem to be of high-impact even though they fall outside our initial intents.
项目总结:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dianqing Wu其他文献
Dianqing Wu的其他文献
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{{ truncateString('Dianqing Wu', 18)}}的其他基金
Signaling mechanisms and functions related to patho-physiology of vascular, lung and blood systems
与血管、肺和血液系统病理生理学相关的信号传导机制和功能
- 批准号:
9244290 - 财政年份:2017
- 资助金额:
$ 91.23万 - 项目类别:
DKK2 regulates NK activation and tumor immunity
DKK2 调节 NK 激活和肿瘤免疫
- 批准号:
10064071 - 财政年份:2017
- 资助金额:
$ 91.23万 - 项目类别:
Signaling mechanisms and functions related to patho-physiology of vascular, lung and blood systems
与血管、肺和血液系统病理生理学相关的信号传导机制和功能
- 批准号:
10570974 - 财政年份:2017
- 资助金额:
$ 91.23万 - 项目类别:
DKK2 regulates NK activation and tumor immunity
DKK2 调节 NK 激活和肿瘤免疫
- 批准号:
10307994 - 财政年份:2017
- 资助金额:
$ 91.23万 - 项目类别:
Identification of novel genes as being important for neutrophil functions
鉴定对中性粒细胞功能重要的新基因
- 批准号:
8415495 - 财政年份:2012
- 资助金额:
$ 91.23万 - 项目类别: