SPORE in Prostate Cancer

总体：摘要 本申请是对罗伯特大学前列腺癌P50 CA 180995的SPORE的更新资金的请求。 H.西北大学Lurie综合癌症中心与芝加哥大学合作 综合癌症中心和北岸大学健康系统，一个附属的大学， 芝加哥。SPORE于2001年首次获得国家癌症研究所的支持;更新申请 2009年获得资助。2015年，我们是新SPORE的接收者，我们现在请求继续 为这个项目提供资金。我们的SPORE联合了基础科学家、临床医生、病理学家、生物统计学家， 生物信息学家和我们学术机构的倡导者，他们都致力于推进 转化前列腺癌研究。在本申请中，我们提出了三个高度转化和创新的 基础科学和临床科学共同领导的研究项目：项目1：瞄准MYC 前列腺癌通路（Abdulkadir，Hussain）;项目2：重新定向转移性前列腺癌的敏感性 去势抵抗性前列腺癌免疫治疗（吴，Sosman，Morgans）;项目3：STING激活， 克服PTEN缺陷型前列腺癌中对免疫检查点阻断的抗性（Patnaik，Gastroski， Stadler）。三个核心设施支持拟议的研究项目：行政，领导和宣传 （Abdulkadir、Hussain、Stadler）;生物统计学/生物信息学（Kocherginsky、Zhao）和生物标本（Yang）。 内部和外部咨询委员会为SPORE团队成员提供科学投入的来源， 分别为半年和一年。我们的宣传小组在SPORE竞技场中建立了良好的基础， 为我们的成功做出有价值的贡献。SPORE包括发展研究和职业生涯 增强计划，两者都提供了创新和新发现的源泉。我们加 预计从我们的研究工作中获得的结果将对健康产生重大影响。 前列腺癌的治疗方法

OVERALL: ABSTRACT This application is a request for renewal funding of the SPORE in Prostate Cancer P50 CA180995 at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University in collaboration with the University of Chicago Comprehensive Cancer Center and NorthShore University HealthSystem, an affiliate of the University of Chicago. The SPORE first received support from the National Cancer Institute in 2001; a renewal application was funded in 2009. In 2015, we were the recipients of a new SPORE and we are now requesting continued funding for this program. Our SPORE unites basic scientists, clinicians, pathologists, biostatisticians, bioinformaticists and advocates from our academic institutions, all of whom are dedicated to advancing translational prostate cancer research. In this application we propose three highly translational and innovative research projects that have both basic science and clinical science co-leadership: Project 1: Targeting the MYC Pathway in Prostate Cancer (Abdulkadir, Hussain); Project 2: Re-directing the sensitivity of metastatic castration-resistant prostate cancer to immunotherapy (Wu, Sosman, Morgans); Project 3: STING Activation to Overcome Resistance to Immune Checkpoint Blockade in PTEN-deficient Prostate Cancer (Patnaik, Gajewski, Stadler). Three core facilities support the proposed research projects: Administrative, Leadership and Advocacy (Abdulkadir, Hussain, Stadler); Biostatistics/Bioinformatics (Kocherginsky, Zhao) and Biospecimen (Yang). Internal and External Advisory Boards provide a source of scientific input to members of the SPORE team on a biannual and yearly basis, respectively. Our Advocacy Group are well established in the SPORE arena and make a valued contribution to our success. The SPORE includes Developmental Research and Career Enhancement Programs, both of which provide a source of innovation and new discoveries. All together, we anticipate that the results obtained from our research endeavors will have a significant impact on the health of patients diagnosed with prostate cancer.