Investigating the Regulation and Role of FOXM1 in Aggressive Meningioma
研究 FOXM1 在侵袭性脑膜瘤中的调节和作用
基本信息
- 批准号:10092806
- 负责人:
- 金额:$ 3.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:Automobile DrivingBiochemistryBioinformaticsBiologicalBiological AssayBiological ModelsBiologyBrain NeoplasmsCell ProliferationCellsCellular biologyCentral Nervous System NeoplasmsCerebrumChIP-seqCharacteristicsClassificationClinicalClinical ResearchClustered Regularly Interspaced Short Palindromic RepeatsCommunicationCommunity Clinical Oncology ProgramDNA MethylationDNA methylation profilingDataExposure toFOXM1 geneFellowshipFoundationsGenesGeneticGenetic TranscriptionGenomicsGoalsGrantGrowthHistologicHistopathologic GradeHumanIn VitroIntracranial NeoplasmsKnowledgeLearningLightMediatingMentorsMentorshipMitoticModelingMolecularMolecular BiologyMutateMutationNeurofibromin 2OncogenicOncologistOperative Surgical ProceduresOrganoidsOutcomePathogenesisPathway interactionsPatient-Focused OutcomesPatientsPharmacologyPhysiciansPhysiologyPreparationProgression-Free SurvivalsRadiationRegulationResearchResearch PersonnelResearch Project GrantsResectedRoleRunningSamplingScienceScientistSpecialized Program of Research ExcellenceSubgroupSyndromeTOP2A geneTestingTrainingTumor BiologyTumor Cell InvasionTumor Suppressor ProteinsUnited StatesWritingbasecancer typecareerclinical databasedemographicsfollow-upimprovedmeningiomamolecular targeted therapiesneoplastic cellneuro-oncologynew technologynew therapeutic targetnovelskillstranscription factortranscriptome sequencingtumortumorigenesis
项目摘要
PROJECT SUMMARY/ABSTRACT
Meningioma is the most common primary central nervous system tumor in the United States. Treatments for
meningiomas include surgery and radiation, but the majority of high-grade meningiomas recur, and there are no
effective systemic or molecular therapies for meningioma patients. A classification based on DNA methylation
better predicts meningioma outcomes than histologic grade, suggesting that understanding the molecular
mechanisms driving meningioma growth is critical for improving patient outcomes. The tumor suppressor NF2 is
the most commonly mutated gene in meningioma, but how NF2 functions in normal physiology and
tumorigenesis remains poorly understood. Thus, very little is known about the molecular drivers of pathogenesis
in meningioma. The overall goal of this research project is to understand the molecular pathways driving
meningioma in order to shed light on novel molecular therapies for meningioma patients. Our preliminary data
demonstrate that meningioma is comprised of 4 molecular subgroups that are associated with distinct patient
demographics, genomic characteristics, and clinical outcomes. The most aggressive subgroup of meningiomas
is defined by enrichment of FOXM1, an oncogenic transcription factor that our lab has shown to be associated
with high-grade meningiomas and meningioma growth. NF2 has been implicated in post-translational
degradation of FOXM1 in other types of cancer. Thus, I hypothesize that loss of NF2 in meningioma stabilizes
FOXM1 expression and activity to drive the growth of aggressive tumors. To define how FOXM1 drives
meningioma growth, Aim 1 proposes to identify and functionally validate FOXM1 target genes in meningioma.
To understand how FOXM1 is activated to drive meningioma, Aim 2 will determine whether FOXM1-mediated
meningioma growth is contingent on NF2 loss. This research will be conducted in the Raleigh lab, within the
UCSF Brain Tumor Center, an NCI-recognized Specialized Program of Research Excellence (SPORE), under
the guidance of my mentors, Dr. Raleigh, a physician-scientist with clinical and research expertise in meningioma
biology, and Dr. Costello, a renowned expert in brain tumor biology with a long track record of successful
mentorship. This project will improve upon my existing molecular and cell biology technical knowledge, create
exposure to new technologies and model systems, and develop new skillsets in biochemistry and bioinformatics.
As part of the fellowship training plan, I will also learn from and integrate into the clinical neuro-oncology
community at UCSF, in preparation for my career goal of becoming a neuro-oncologist physician-scientist.
Furthermore, I will develop professional skills, such as science communication and grant writing, which are
essential for becoming a physician-scientist running a lab as an independent researcher.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Abrar Choudhury其他文献
Abrar Choudhury的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Abrar Choudhury', 18)}}的其他基金
Investigating the Regulation and Role of FOXM1 in Aggressive Meningioma
研究 FOXM1 在侵袭性脑膜瘤中的调节和作用
- 批准号:
9906474 - 财政年份:2020
- 资助金额:
$ 3.78万 - 项目类别:
Investigating the Regulation and Role of FOXM1 in Aggressive Meningioma
研究 FOXM1 在侵袭性脑膜瘤中的调节和作用
- 批准号:
10549807 - 财政年份:2020
- 资助金额:
$ 3.78万 - 项目类别:
Investigating the Regulation and Role of FOXM1 in Aggressive Meningioma
研究 FOXM1 在侵袭性脑膜瘤中的调节和作用
- 批准号:
10322370 - 财政年份:2020
- 资助金额:
$ 3.78万 - 项目类别:
相似海外基金
Identification of Pathogenic Protein Mutations using Synthetic Biology, Structural Bioinformatics and Biochemistry
利用合成生物学、结构生物信息学和生物化学鉴定致病蛋白突变
- 批准号:
2106288 - 财政年份:2018
- 资助金额:
$ 3.78万 - 项目类别:
Studentship
Applying Bioinformatics and Biochemistry Tools to support the Craft Brewing Industry in BC
应用生物信息学和生物化学工具支持 BC 的精酿啤酒业
- 批准号:
517930-2017 - 财政年份:2018
- 资助金额:
$ 3.78万 - 项目类别:
College and Community Innovation Program - Entry Level
Applying Bioinformatics and Biochemistry Tools to support the Craft Brewing Industry in BC
应用生物信息学和生物化学工具支持 BC 的精酿啤酒业
- 批准号:
517930-2017 - 财政年份:2017
- 资助金额:
$ 3.78万 - 项目类别:
College and Community Innovation Program - Entry Level
The protein phosphatses of arabidopsis thaliana: bioinformatics, biochemistry and function
拟南芥蛋白磷酸盐:生物信息学、生物化学和功能
- 批准号:
216895-2008 - 财政年份:2012
- 资助金额:
$ 3.78万 - 项目类别:
Discovery Grants Program - Individual
FINDING NOVEL REAGENTS BY BIOINFORMATICS AND BIOCHEMISTRY
通过生物信息学和生物化学寻找新试剂
- 批准号:
8251388 - 财政年份:2012
- 资助金额:
$ 3.78万 - 项目类别:
FINDING NOVEL REAGENTS BY BIOINFORMATICS AND BIOCHEMISTRY
通过生物信息学和生物化学寻找新试剂
- 批准号:
8488588 - 财政年份:2012
- 资助金额:
$ 3.78万 - 项目类别:
FINDING NOVEL REAGENTS BY BIOINFORMATICS AND BIOCHEMISTRY
通过生物信息学和生物化学寻找新试剂
- 批准号:
8542875 - 财政年份:2012
- 资助金额:
$ 3.78万 - 项目类别:
The protein phosphatses of arabidopsis thaliana: bioinformatics, biochemistry and function
拟南芥蛋白磷酸盐:生物信息学、生物化学和功能
- 批准号:
216895-2008 - 财政年份:2011
- 资助金额:
$ 3.78万 - 项目类别:
Discovery Grants Program - Individual
The protein phosphatses of arabidopsis thaliana: bioinformatics, biochemistry and function
拟南芥蛋白磷酸盐:生物信息学、生物化学和功能
- 批准号:
216895-2008 - 财政年份:2010
- 资助金额:
$ 3.78万 - 项目类别:
Discovery Grants Program - Individual
The protein phosphatses of arabidopsis thaliana: bioinformatics, biochemistry and function
拟南芥蛋白磷酸盐:生物信息学、生物化学和功能
- 批准号:
216895-2008 - 财政年份:2009
- 资助金额:
$ 3.78万 - 项目类别:
Discovery Grants Program - Individual