Training Program in Lung Biology and Translational Medicine

描述（由申请人提供）：项目负责人/主要研究者（最后，第一，中间）：Thannickal，维克托J.摘要伯明翰亚拉巴马大学（UAB）的“肺生物学和转化医学培训项目”的目标是在一个激励和协作的环境中提供多学科培训，培养高度胜任和创新的生物医学研究科学家。该计划将支持2-3年的结构化和严格的研究培训，为医学博士。或博士博士后拟议的培训的多学科性质是由谁在九个UAB部门（5 -基础科学; 4 -临床）持有主要任命的26名教师导师的多样性培育。此外，我们将聘请一个有才华和充满活力的“初级导师”谁将参加一个“小组辅导”计划。教师导师根据科学专业知识分为三个主题领域：（1）免疫学-微生物学;（2）细胞生物学-组织修复;（3）转化科学。统计遗传学、计算生物学、生物标志物发现、药物发现/开发和临床试验（第3组）的转化研究将促进基础科学研究（第1组和第2组）的临床转化。基于UAB现有的专业知识和正在进行的研究工作，培训将侧重于肺部疾病的表现，诊断，风险/预后分层，机制，预防和治疗，主要是急性肺损伤（ALI），囊性纤维化（CF），哮喘，慢性阻塞性肺病（COPD）和间质性肺病（ILD）。培训计划将高度个性化和量身定制，以最大限度地提高每个学员的成功。除了将在导师实验室进行的研究项目外，培训还将包括一个高度结构化的教学计划，其中包括肺、过敏和重症监护医学部的每周教学会议，这是一门“生存技能”课程。（与UAB临床和转化科学中心合作）和研究核心课程，包括新兴主题，如细胞可塑性，药物发现/开发、系统生物学和个性化医疗。正式的指导将包括负责任和道德的研究行为。将大力强调征聘和留住任职人数不足的少数族裔。PHS 398/2590（Rev. 11/07）

DESCRIPTION (provided by applicant): Program Director/Principal Investigator (Last, First, Middle): Thannickal, Victor J. ABSTRACT The goal of the "Training Program in Lung Biology and Translational Medicine" at the University of Alabama at Birmingham (UAB) is to provide multidisciplinary training in a stimulating and collaborative environment that nurtures the development of highly competent and innovative biomedical research scientists. The program will support 2-3 years of structured and rigorous research training for M.D. or Ph.D. postdoctoral fellows. The multidisciplinary nature of the proposed training is fostered by the diversity of the twenty-six faculty mentors who hold primary appointments in nine UAB Departments (5 - basic science; 4 - clinical). Additionally, we will engage a talented and dynamic group of "junior mentors" who will participate in a "group mentoring" plan. The faculty mentors have been grouped into three thematic areas based on scientific expertise: (1) immunology-microbiology; (2) cell biology-tissue repair; (3) translational sciences. Translational research in statistical genetics, computational biology, biomarker discovery, and drug discovery/development and clinical trials (group 3) will facilitate the clinical translation of basic science research (groups 1 and 2). Based on the existing expertise and ongoing research efforts at UAB, training will focus on the manifestations, diagnosis, risk/prognostic stratification, mechanisms, prevention, and treatment of lung diseases, primarily acute lung injury (ALI), cystic fibrosis (CF), asthma, chronic obstructive lung diseases (COPD), and interstitial lung diseases (ILD). Training programs will be highly individualized and tailored to maximize success of each trainee. In addition to the research projects that will be conducted in the mentor's laboratory, training will encompass a highly structured didactic program that includes weekly teaching conferences in the Division of Pulmonary, Allergy and Critical Care Medicine, a "survival skills" curriculum (in collaboration with the Center for Clinical and Translational Science at UAB) and a Research Core Curriculum that includes emerging themes such as cellular plasticity, drug discovery/development, systems biology, and personalized medicine. Formal instruction will include the responsible and ethical conduct of research. Strong emphasis will be placed on the recruitment and retention of underrepresented minorities. PHS 398/2590 (Rev. 11/07) Page Continuation Format Page