Training Program in Lung Biology and Translational Medicine

描述(由申请人提供)：项目主任/首席研究员(最后、第一、中间)：Thanickal，Victor J.摘要阿拉巴马大学伯明翰分校(UAB)“肺生物学和转化医学培训计划”的目标是在激励和协作的环境中提供多学科培训，以培养高能力和创新的生物医学研究科学家。该计划将为医学博士或博士后研究员提供2-3年的系统和严格的研究培训。拟议培训的多学科性质是由26名教员导师的多样性促进的，他们在9个UAB部门(5-基础科学；4-临床)担任主要职务。此外，我们将聘请一群才华横溢、充满活力的“初级导师”，他们将参与“团体辅导”计划。教师导师根据科学专长被分成三个主题领域：(1)免疫学-微生物学；(2)细胞生物学-组织修复；(3)翻译科学。统计遗传学、计算生物学、生物标记物发现、药物发现/开发和临床试验方面的翻译研究(第3组)将促进基础科学研究的临床翻译(第1和第2组)。基于UAB现有的专业知识和正在进行的研究工作，培训将侧重于肺部疾病的表现、诊断、风险/预后分层、机制、预防和治疗，主要是急性肺损伤(ALI)、囊性纤维化(CF)、哮喘、慢性阻塞性肺疾病(COPD)和间质性肺疾病(ILD)。培训计划将高度个性化并量身定做，以最大限度地提高每个受训者的成功。除了将在导师的实验室进行的研究项目外，培训还将包括一个高度结构化的教学计划，其中包括每周在肺、过敏和危重护理医学部举行的教学会议，一个“生存技能”课程(与加州大学伯克利分校临床和转化科学中心合作)和一个研究核心课程，其中包括细胞可塑性、药物发现/开发、系统生物学和个性化医学等新兴主题。正式的指导将包括负责任和合乎道德的研究行为。将大力强调招募和保留任职人数偏低的少数群体。PHS 398/2590(11/07版)页面续格式页面

DESCRIPTION (provided by applicant): Program Director/Principal Investigator (Last, First, Middle): Thannickal, Victor J. ABSTRACT The goal of the "Training Program in Lung Biology and Translational Medicine" at the University of Alabama at Birmingham (UAB) is to provide multidisciplinary training in a stimulating and collaborative environment that nurtures the development of highly competent and innovative biomedical research scientists. The program will support 2-3 years of structured and rigorous research training for M.D. or Ph.D. postdoctoral fellows. The multidisciplinary nature of the proposed training is fostered by the diversity of the twenty-six faculty mentors who hold primary appointments in nine UAB Departments (5 - basic science; 4 - clinical). Additionally, we will engage a talented and dynamic group of "junior mentors" who will participate in a "group mentoring" plan. The faculty mentors have been grouped into three thematic areas based on scientific expertise: (1) immunology-microbiology; (2) cell biology-tissue repair; (3) translational sciences. Translational research in statistical genetics, computational biology, biomarker discovery, and drug discovery/development and clinical trials (group 3) will facilitate the clinical translation of basic science research (groups 1 and 2). Based on the existing expertise and ongoing research efforts at UAB, training will focus on the manifestations, diagnosis, risk/prognostic stratification, mechanisms, prevention, and treatment of lung diseases, primarily acute lung injury (ALI), cystic fibrosis (CF), asthma, chronic obstructive lung diseases (COPD), and interstitial lung diseases (ILD). Training programs will be highly individualized and tailored to maximize success of each trainee. In addition to the research projects that will be conducted in the mentor's laboratory, training will encompass a highly structured didactic program that includes weekly teaching conferences in the Division of Pulmonary, Allergy and Critical Care Medicine, a "survival skills" curriculum (in collaboration with the Center for Clinical and Translational Science at UAB) and a Research Core Curriculum that includes emerging themes such as cellular plasticity, drug discovery/development, systems biology, and personalized medicine. Formal instruction will include the responsible and ethical conduct of research. Strong emphasis will be placed on the recruitment and retention of underrepresented minorities. PHS 398/2590 (Rev. 11/07) Page Continuation Format Page