Johns Hopkins HIV and Heart, Lung, Blood & Sleep Disorders Training Program (H3TP)

项目摘要 霍普金斯大学艾滋病毒与心肺、血液和睡眠障碍培训计划的长期目标 (H3TP)是培养和发展一支优秀的调查人员队伍，他们将促进知识和 改善艾滋病毒感染者(PLWH)及其心脏、肺、血液和血液共病患者的预后 睡眠(HLBS)障碍。这一目标与NHLBI的任务和艾滋病研究办公室直接相关 高度优先的研究问题，以解决老龄化与艾滋病毒并存的问题。在这个新的K-12计划中， 我们将通过实施以下具体目标来实现这一目标：(1)提供 为博士后研究员和初级教员提供严格的指导培训经验，以开展研究 HLBS在艾滋病毒共病中的利基地位；(2)利用Johns Hopkins HIV HLBS可用的丰富资源 调查人员访问具有良好特征的患者和队列人群的数据，以使学员项目能够 迅速启动和执行；(3)提供获得杰出的方法和分析专业知识的途径 促进研究成功；(4)让受训人员参与高素质的协作研究项目，以解决 重要问题和检验有意义的假设在全国知名的多 学科教师；(5)整合多层次和个性化的指导，以供每个学员发展 有意义的奖学金和成功的调查事业；以及(6)评估该计划的结果 并进行修改，以最大限度地提高其成功。 在这项提案中，我们利用约翰霍普金斯大学杰出的艾滋病毒和HLBS研究社区，包括 支持培训和研究的现有临床和翻译基础设施、高效的计划 教职员工，充满活力的跨部门和跨部门多学科合作，优秀的机构 致力于博士后和早期研究人员的高水平培训。通过这些计划 根据我们的特点，我们预计我们的受训人员将拥有强大的候选人人才库和出色的成绩。 我们的计划结合了多学科矩阵中单一调查领域的强化培训 将为博士后和初级教师培训人员提供1-3年的支持。范围广泛的 培训机会由一个庞大的互动教职员工网络提供，并得到大量赠款的支持 公文包。体验的核心是主要导师、合作导师和 受训人员围绕特定的研究项目。个性化的培训体验，通过使用个人进行指导 发展计划，将由正规的课程工作补充，可以获得研究生学位，以及 一系列丰富活动，包括参加核心H3TP论坛，与一群类似- 阶段性受训人员、个性化会议、负责任的研究行为培训、职业规划、补助金 写作和手稿准备。过程措施的多点反馈和监控将 告知并指导我们新制定的计划，以确保我们目标的实现。

Project Summary The long-term objective of the Hopkins HIV and Heart, Lung, Blood and Sleep Disorders Training Program (H3TP) is to train and develop a cadre of outstanding investigators who will advance knowledge and improve outcomes for people living with HIV infection (PLWH) and comorbid heart, lung, blood and sleep (HLBS) disorders. This goal is directly relevant to the NHLBI mission and to the Office of AIDS Research high priority research issues to address comorbidities in the setting of aging with HIV. In this new K-12 proposal, we will be accomplish this objective through implementation of the following Specific Aims: (1) Provide a rigorous, mentored training experience for postdoctoral fellows and junior faculty to develop a research niche in HLBS comorbidities in HIV; (2) Utilize the rich resources available to Johns Hopkins HIV HLBS investigators to access data on well-characterized patient and cohort populations to enable trainee projects to be rapidly initiated and executed; (3) Provide access to outstanding methodologic and analytic expertise to facilitate research success; (4) Engage trainees in high caliber collaborative research projects that address important questions and test meaningful hypotheses under the supervision of nationally-renowned multi- disciplinary faculty; (5) Integrate multi-layered and individualized mentorship for each trainee to develop meaningful scholarship and a successful investigative career; and (6) Assess the outcomes of the program and make modifications to maximize its success. In this proposal, we leverage the outstanding community of HIV and HLBS research at Johns Hopkins including existing clinical and translational infrastructure to support training and research, highly productive program faculty, vibrant interdepartmental and interdivisional multidisciplinary collaborations, excellent institutional commitment to high level training of postdoctoral and early stage investigators. With these program characteristics, we anticipate a robust pool of candidates and outstanding outcomes for our trainees. Our program combines intensive training in a single area of investigation within a matrix of multidisciplinary collaborations and will support post-doctoral and entry-level faculty trainees for 1-3 years. A wide range of training opportunities are provided by a large interactive network of faculty supported by a substantial grant portfolio. The core of the experience is the close relationship between a primary mentor, co-mentors, and the trainee around specific research projects. A personalized training experience, guided through use of individual development plans, will be supplemented by formal course work which can lead to a graduate degree, and a series of enrichment activities including participation in a core H3TP forum, peer learning with a cohort of similar- staged trainees, individualized conferences, training in responsible research conduct, career planning, grant writing, and manuscript preparation. Multiple points of feedback and monitoring of process measures will inform and guide our newly constituted program to ensure our objectives are achieved.