UCSF Comprehensive Lab Animal Monitoring System

描述(由申请者提供)：这项共享设备赠款是为12室综合实验室动物监测系统(CLAMS)提供的，该系统能够有效和精确地测量小鼠的摄食、基础代谢、运动活动和体温调节。这些参数的准确测量对于阐明肥胖和代谢性疾病的机制至关重要。目前，加州大学旧金山分校越来越多的研究人员正在进行肥胖和代谢综合征的研究，但没有类似的设备可用。无法用常规方法测量研究动物的关键代谢参数，阻碍了这一领域的研究进展。在这份申请中，加州大学旧金山分校的一组研究人员描述了他们由NIH支持的研究项目，这些项目将从收购CLAMS系统中获得显著好处。如果获得资金，CLAMS系统将被整合到加州大学旧金山分校的代谢核心中，该核心将由加州大学旧金山分校糖尿病中心的指定人员管理和维护。已经制定了详细的管理计划，以确保该仪器的成本效益。随着肥胖症、2型糖尿病和代谢性疾病患病率的上升，拟议中的仪器的安装将极大地增加现有研究工作的能力，并将吸引更多的研究人员来研究肥胖症和代谢紊乱。

DESCRIPTION (provided by applicant): This shared equipment grant is for a 12-chamber Comprehensive Lab Animal Monitoring System (CLAMS) that enables efficient and precise measurements of feeding, basal metabolism, motor activities, and thermoregulation in mice. The accurate measurements of these parameters are essential for elucidating the mechanisms underlying obesity and metabolic diseases. Currently, no comparable equipment is accessible to an increasing number of UCSF investigators who are conducting research on obesity and metabolic syndromes. The inability to measure key metabolic parameters in research animals by conventional methods has impeded research progress in this field. In this application, a group of UCSF investigators have described their NIH-supported research projects that would significantly benefit from the acquisition of a CLAMS system. The CLAMS system, if funded, will be integrated into the UCSF Metabolic Core, which will be managed and maintained by designated personnel at the UCSF Diabetes Center. Detailed management plan has been formulated to ensure cost-effective operation of the instrument. With prevalence of obesity, type 2 diabetes and metabolic diseases on the rise, the installation of the proposed instrument would dramatically increase the capacity of existing research efforts, and will attract an even larger number of investigators to study obesity and metabolic disorders.