Multiwavelength diode laser system for PDT

描述（由申请人提供）：我们是一个由10名多学科研究人员组成的小组，代表加州大学欧文分校的6个部门，拥有11项联邦资助的研究经费，受本次仪器申请的影响。我们正在为贝克曼激光研究所的NIH-NCRR生物医学技术资源中心（P41-RR01192，激光微束和医疗项目，LAMMP）内的多波长光动力治疗（PDT）连续波光源寻求资金支持。LAMMP设施致力于定义和理解与使用光作为诊断和治疗工具相关的广泛问题。自20世纪80年代初以来，BLI一直致力于PDT科学的发展，推进和翻译，我们的中心在技术开发方面拥有非常强大的基础。迫切需要一个商业的，用户友好的多波长PDT光源被安置和管理在我们的NIH资源。在美国，很少有中心能够执行本提案中描述的项目。PDT科学在欧洲和亚洲要先进得多。拟议的项目是作为试点/可行性研究启动的，使用过时的光源限制了PDT科学向临床应用的转化。我们中心迫切需要升级和利用商业上可用的技术来支持这项研究，并将我们的技术转化为患者使用。这些美国国立卫生研究院资助的研究人员在没有这种仪器的情况下继续取得进展受到阻碍。基于LAMMP现有的强大影响及其向同事和合作者传播新发现，预计所要求的仪器将对加州大学欧文分校的研究界及其他领域产生重大的整体效益。

DESCRIPTION (provided by applicant): We are a group of 10 multi-disciplinary investigators representing 6 departments at the University of California, Irvine with 11 federally funded research grants impacted by this request for instrumentation. We are seeking funds for a multi-wavelength photodynamic therapy (PDT) continuous wave light source to be housed and supported within the well-established NIH-NCRR Biomedical Technology Resource Center (P41-RR01192, Laser Microbeam and Medical Program, LAMMP) at the Beckman Laser Institute. The LAMMP facility is dedicated to defining and understanding broad issues related to the use of light as a diagnostic and therapeutic tool. BLI has been involved in developing, advancing and translating PDT science since the early 1980's and our center has a very strong foundation in technology development. There is an urgent need for a commercial, user-friendly multi-wavelength PDT light source to be housed and managed within our NIH resource. There are very few centers in the United States capable of performing the projects described in this proposal. PDT science is much more advanced in Europe and Asia. The proposed projects were initiated as pilot/feasibility studies using obsolete light sources limiting translation of the PDT science to clinical application. There is a critical need at our center to upgrade and utilize commercially available technology to support this research and to translate our technologies for patient use. Continued progress for these NIH-funded investigators is hampered without access to such an instrument. It is expected that the requested instrumentation will have a significant overall benefit to the UC Irvine research community and beyond, based on the existing strong impact of the LAMMP and its dissemination of new discoveries to colleagues and collaborators.