Medical physics and biomedical technology development for next generation dose measurement, optimization and computation tools

下一代剂量测量、优化和计算工具的医学物理和生物医学技术开发

• 批准号: RGPIN-2019-05038
• 负责人: Beaulieu, Luc
• 金额: $ 5.46万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=691896
• 关键词: Medical; physics; biomedical; technology; development

Cancer is now the most important cause of premature death in industrialized country and around 50% of cancer patients will have one form of radiation therapy, alone and in combination with surgery and chemotherapy, as part of their treatments. As with any cytotoxic agents, radiation, which must be used safely, has the distinct advantages of being a local treatment modality for which the basic interaction processes with matter are well-known (relative to systemic chemotherapy agents) i.e. the physical dose and its spatial extension can be predicted with high precision. The search for novel approaches to cure or manage cancer is extremely active. Still, a recent review shows that cancers are mainly “cured” using surgery and radiation therapy. This is because surgery and radiation therapy are also benefiting from continuous technological and scientific advances. ******Our research program is rooted in this paradigm as the ongoing, long-term objective of the research program is to increase the accuracy of dose measurements, dose optimization and dose calculations for radiation-based precision medicine. This is achieved through a comprehensive research program combining elements of basic and applied research in medical physics and biomedical engineering. The proposed program hinges on radiation physics, optics, numerical optimization problems, image and signal processing and high-performance numerical computing. It is a well-established, wide-ranging and highly productive research program. The methodology used combines both experimental and numerical approaches to build tools and algorithms that are novel and clinically relevant to radiation medicine. ******The 5-year objectives for this renewal spreads along three main research tracks: ***1) Development of new plan optimization algorithms, ***2) Development of novel scintillation dosimeters, ***3) Monte Carlo method for radiation-matter simulations. ******Our close connection with clinical teams ensures that our program, and its 5-year objectives listed above, are strongly connected with real clinical need. More importantly, the application of the said technologies and algorithms that we are developing has the potential for improved precision of radiation medicine, and thus quality of life of patients, in Canada and worldwide. As a result, they are highly sought after by the various stakeholders (clinicians, researchers, ) as well as the biomedical technology industry partners, actual and future.

现在，癌症是工业化国家过早死亡的最重要原因，大约50％的癌症患者将单独使用一种放射疗法，并与手术和化学疗法结合使用，作为其治疗的一部分。与任何细胞毒性剂一样，必须安全地使用的辐射具有明显的优势，即是局部治疗方式，基本的相互作用过程与物质是众所周知的（相对于全身化学疗法剂），即物理剂量及其空间差异，可以高精度地预测。寻找治愈或管理癌症的新方法非常活跃。尽管如此，最近的评论表明，癌症主要使用手术和放射治疗“治愈”。这是因为手术和放射疗法也从连续的技术和科学进步中受益。 *****我们的研究计划植根于该范式，因为研究计划的持续，长期目标是提高剂量测量，剂量优化和基于辐射精度医学的剂量计算的准确性。这是通过一项全面的研究计划来实现的，该计划结合了医学物理和生物医学工程领域的基础研究和应用研究的要素。所提出的程序取决于辐射物理，光学，数值优化问题，图像和信号处理以及高性能数值计算。这是一项良好的，广泛的且高产的研究计划。使用的方法结合了实验和数值方法，以构建与放射医学相关的新颖且临床上有关的工具和算法。 *****该更新的5年目标沿着三个主要研究轨道传播：*** 1）开发新计划优化算法，*** 2）开发新型闪烁的Dosimeterter，*** 3）蒙特卡洛方法用于辐射模拟模拟。 ****我们与临床团队的密切联系确保我们的计划及其5年目标与实际临床需求密切相关。更重要的是，我们正在开发的上述技术和算法的应用有可能提高放射医学的精度，并在加拿大和全球范围内的患者生活质量。结果，他们受到各种利益相关者（临床医生，研究人员）以及生物医学技术行业伙伴的高度追捧。