权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

MRI Scanner (3T) for Research in Catastrophic Diseases of Childhood

用于儿童灾难性疾病研究的 MRI 扫描仪 (3T)

基本信息

批准号：
7840308
负责人：
ROBERT J OGG
金额：
$ 277.2万
依托单位：
ST. JUDE CHILDREN'S RESEARCH HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-20 至 2011-05-19
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7840308
关键词：
AIDS/HIV problem Accounting Adult Adverse effects American Architecture Arts Award Child Child health care Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Diagnosis Disease Employee Employment Engineering Ensure Environmental Impact Funding Grant Housing Human Image Institution Investigation Lead Life Magnetic Resonance Imaging Magnetism Malignant Childhood Neoplasm Malignant Neoplasms Medical Occupations Operating System Pathogenesis Positioning Attribute Postdoctoral Fellow Quality of life Recovery Research Research Activity Research Personnel Research Project Grants Resources Saint Jude Children&apos s Research Hospital Scanning Schedule Scientist Services Sickle Cell Anemia Solutions Support System Survivors System Technology Time Treatment outcome United States United States National Institutes of Health Work adverse outcome cost design graduate student improved instrument instrumentation programs public health relevance rapid growth research study software systems

项目摘要

DESCRIPTION (provided by applicant): A high-end instrumentation grant is requested to purchase a research- dedicated 3.0 T Siemens Verio MRI scanner for human translational and clinical imaging research at St. Jude Children's Research Hospital. St. Jude is a charitably funded institution dedicated to advancing cures for catastrophic diseases of childhood through treatment and research. Imaging scientists and clinical investigators will use the instrument in major NIH-funded research programs to study children with pediatric cancers, sickle cell disease, and HIV/AIDS, and also adult survivors of these diseases. The objectives of the research to be conducted with the MRI scanner are to understand disease pathogenesis, improve diagnosis and assessment of disease extent, enhance treatment outcome, and quantitate adverse consequences of treatment. Currently, MRI imaging research activities of St. Jude investigators are accommodated by 3 clinical MRI scanners (two 1.5 T, one 3.0 T), but current resources are no longer sufficient because of rapid growth in demand for both clinical and research MR imaging. Research studies account for approximately 50% of all scans on the existing scanners, which operate at greater than 90% of capacity. The high utilization rate of available MRI scanners limits the efficiency of current research projects because of difficulty scheduling examinations, discourages colleagues in clinical investigation from collaborative imaging research objectives, and precludes the initiation of important new lines of investigation because imaging time is always sparse and sometimes unavailable. The 3T instrument is urgently needed to support the human imaging needs of NIH- supported biomedical researchers at St. Jude. The Verio scanner was chosen because it includes the most advanced MRI technology available, and because the St. Jude imaging scientists, in-house service engineers, and MRI Technologists who will operate the system have expertise in Siemens system software and hardware architecture. The scanner will be located in an existing empty MRI bay adjacent to our clinical MRI scanners. With institutional commitments to complete the vacant bay (RF and magnetic shielding, completion of internal features) and support initial operational costs, the new system will be installed and operational within 6 months of the grant award. The installation of this MRI scanner will lead to the creation of 2 jobs at St. Jude within the first 6 months of the award for direct operational support of the system, and we anticipate an additional 2 positions for post doctoral fellows, graduate students, and research assistants within 24 months to support the expanded research programs of participating investigators. Access to the research-dedicated scanner will also help ensure the jobs of the employees currently supported by NIH users' grants; purchase of the Verio system will help to sustain and grow the Siemens workforce in the United States. American Recovery and Reinvestment Act funds invested in this instrument will be put to work quickly for compelling research programs to improve the health of children, our most important national resource. PUBLIC HEALTH RELEVANCE: A state-of-the-art MRI scanner is needed for research at St. Jude Children's Research Hospital to improve the lives of children with cancer, sickle cell disease, and HIV/AIDS, and also adult survivors of these diseases. The objectives of the research are to understand the causes of disease, improve diagnosis and assessment of disease extent, and quantify side effects of treatment - all leading toward increased survival and improved quality of life for survivors. Purchase of the MRI scanner, a Siemens Verio that is designed and manufactured to reduce adverse environmental impact, will create 4 jobs at St. Jude Children's Research Hospital within 2 years, support construction activities at St. Jude, and strengthen the employment position of Siemens Medical Solutions in the United States.

描述（由申请人提供）：请求高端仪器补助金购买一台研究专用 3.0 T 西门子 Verio MRI 扫描仪，用于圣裘德儿童研究医院的人体转化和临床成像研究。圣裘德是一家慈善机构，致力于通过治疗和研究促进儿童灾难性疾病的治疗。成像科学家和临床研究人员将在 NIH 资助的主要研究项目中使用该仪器来研究患有儿科癌症、镰状细胞病和艾滋病毒/艾滋病的儿童以及这些疾病的成年幸存者。使用 MRI 扫描仪进行的研究的目的是了解疾病发病机制、改进疾病程度的诊断和评估、提高治疗效果并量化治疗的不良后果。目前，St. Jude 研究人员的 MRI 成像研究活动由 3 台临床 MRI 扫描仪（两台 1.5 T、一台 3.0 T）来满足，但由于临床和研究 MR 成像需求的快速增长，当前资源已不再充足。研究工作约占现有扫描仪所有扫描的 50%，现有扫描仪的运行能力超过 90%。由于难以安排检查，可用 MRI 扫描仪的高利用率限制了当前研究项目的效率，阻碍了临床研究同事实现协作成像研究目标，并阻碍了重要的新研究方向的启动，因为成像时间总是稀疏且有时不可用。迫切需要 3T 仪器来支持 NIH 支持的 St. Jude 生物医学研究人员的人体成像需求。之所以选择 Verio 扫描仪，是因为它包含最先进的 MRI 技术，还因为将操作系统的 St. Jude 成像科学家、内部服务工程师和 MRI 技术人员拥有西门子系统软件和硬件架构方面的专业知识。该扫描仪将位于与我们的临床 MRI 扫描仪相邻的现有空 MRI 隔间中。由于机构承诺完成空置间隔（射频和磁屏蔽、完成内部功能）并支持初始运营成本，新系统将在拨款后 6 个月内安装并投入运行。安装这台 MRI 扫描仪后，圣裘德将在获得该系统直接运营支持后的前 6 个月内创造 2 个工作岗位，我们预计在 24 个月内将额外增加 2 个博士后研究员、研究生和研究助理职位，以支持参与研究人员扩展的研究项目。使用研究专用扫描仪也将有助于确保目前由 NIH 用户资助支持的员工的工作；购买 Verio 系统将有助于维持和发展西门子在美国的员工队伍。投资于该工具的《美国复苏和再投资法案》资金将迅速用于引人注目的研究项目，以改善儿童的健康，这是我们最重要的国家资源。公共健康相关性：圣裘德儿童研究医院的研究需要最先进的 MRI 扫描仪，以改善患有癌症、镰状细胞病和艾滋病毒/艾滋病的儿童以及这些疾病的成年幸存者的生活。该研究的目的是了解疾病的原因，改进疾病程度的诊断和评估，并量化治疗的副作用——所有这些都可以提高幸存者的生存率和生活质量。购买 MRI 扫描仪（一款专为减少不利环境影响而设计和制造的西门子 Verio）将在 2 年内为圣裘德儿童研究医院创造 4 个就业岗位，支持圣裘德的建设活动，并加强西门子医疗解决方案在美国的就业地位。