Purchase of a Typhoon Phosphorimager-Fluoroimager for the Keck Biophysics Facilit

为凯克生物物理设施购买一台台风荧光成像仪-荧光成像仪

• 批准号: 7794543
• 负责人: Jonathan Widom
• 金额: $ 11.99万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-20 至 2011-02-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794543
• 关键词: Alzheimer' s Disease; Arts; Biological Sciences; Biophysics; Bone Diseases; Brain; Cell division; Chronic Obstructive Airway Disease; Communities; Equipment; Eukaryotic Cell; Funding; Gel; Genomics; Hour; Huntington Disease; Image; Infertility; Institution; Malignant Neoplasms; Molecular; Parkinson Disease; Pharmaceutical Preparations; Polycystic Kidney Diseases; Research; Research Personnel; Research Project Grants; Resource Sharing; Signal Pathway; Structure; Technical Expertise; Therapeutic; Universities; base; human disease; innovation; instrument

DESCRIPTION (provided by applicant): This is a proposal to acquire a state of the art Typhoon Fluoroimager/Phosphoimager as a shared instrument for the Northwestern University research community. This instrument provides versatile imaging capabilities and exceptional sensitivity for characterization of fluorescent and chemifluorescent gels and blots. Such capabilities are required by many NIH-funded projects currently underway at NU (including, but not limited to, the 15 projects described in detail in this application) and are not available at Northwestern or at other nearby academic institutions. The instrument will be integrated in the Keck Biophysics Facility - a well known resource of shared equipment and technical expertise available to NU researchers on a 24 hours a day, 7 days a week basis. The need for the capabilities provided by the Typhoon imager for the NU Life Sciences research community cannot be underscored: about 40 research groups would benefit from such capabilities on a daily basis; research projects include those seeking to understand basic aspects of genomic structure and function, signaling pathways central to eukaryotic cell division and differentiation, or molecular origins of various human diseases (e.g., Huntington's disease, Parkinson's disease, Alzheimer's disease, polycystic kidney disease, chronic obstructive pulmonary disease), as well as those aiming to develop revolutionary drugs and innovative therapeutic strategies for cancer, infertility, and brain and bone disorders.

描述（由申请人提供）：这是获得最先进的台风氟化物/磷光iMimager的建议，作为西北大学研究社区的共享工具。该仪器为表征荧光和化学荧光凝胶和印迹的表征提供了多功能的成像功能和出色的灵敏度。当前在NU正在进行的NIH资助项目（包括但不限于本申请中详细描述的15个项目）所要求的功能是必需的，在Northwestern或其他附近的学术机构都无法获得。 该仪器将集成到凯克生物物理学设施中 - NU研究人员每周24小时可提供共享设备和技术专业知识的知名资源。 台风成像师为NU Life Sciences研究社区提供的功能的需求不能突显：大约40个研究小组每天将从此类能力中受益；研究项目包括试图了解基因组结构和功能的基本方面的研究项目，信号通路，对真核细胞分裂和分化的核心，或各种人类疾病的分子起源（例如，亨廷顿氏病，帕金森氏病，帕金森氏病，阿尔茨海默氏病，阿尔茨海默氏病，多余的肾脏疾病，多余的肾脏疾病，慢性阻塞性肺部疾病以及那些涉及策略性疾病），以及涉及策略性的策略性，涉及范围，不育，大脑和骨骼疾病。