Purchase of a Typhoon Phosphorimager-Fluoroimager for the Keck Biophysics Facilit

为凯克生物物理设施购买一台台风荧光成像仪-荧光成像仪

• 批准号: 7794543
• 负责人: Jonathan Widom
• 金额: $ 11.99万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-20 至 2011-02-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7794543
• 关键词: Alzheimer' s Disease; Arts; Biological Sciences; Biophysics; Bone Diseases; Brain; Cell division; Chronic Obstructive Airway Disease; Communities; Equipment; Eukaryotic Cell; Funding; Gel; Genomics; Hour; Huntington Disease; Image; Infertility; Institution; Malignant Neoplasms; Molecular; Parkinson Disease; Pharmaceutical Preparations; Polycystic Kidney Diseases; Research; Research Personnel; Research Project Grants; Resource Sharing; Signal Pathway; Structure; Technical Expertise; Therapeutic; Universities; base; human disease; innovation; instrument

DESCRIPTION (provided by applicant): This is a proposal to acquire a state of the art Typhoon Fluoroimager/Phosphoimager as a shared instrument for the Northwestern University research community. This instrument provides versatile imaging capabilities and exceptional sensitivity for characterization of fluorescent and chemifluorescent gels and blots. Such capabilities are required by many NIH-funded projects currently underway at NU (including, but not limited to, the 15 projects described in detail in this application) and are not available at Northwestern or at other nearby academic institutions. The instrument will be integrated in the Keck Biophysics Facility - a well known resource of shared equipment and technical expertise available to NU researchers on a 24 hours a day, 7 days a week basis. The need for the capabilities provided by the Typhoon imager for the NU Life Sciences research community cannot be underscored: about 40 research groups would benefit from such capabilities on a daily basis; research projects include those seeking to understand basic aspects of genomic structure and function, signaling pathways central to eukaryotic cell division and differentiation, or molecular origins of various human diseases (e.g., Huntington's disease, Parkinson's disease, Alzheimer's disease, polycystic kidney disease, chronic obstructive pulmonary disease), as well as those aiming to develop revolutionary drugs and innovative therapeutic strategies for cancer, infertility, and brain and bone disorders.

描述(由申请人提供)：这是一项收购最先进的台风荧光成像仪/磷光成像仪的提案，作为西北大学研究社区的共享仪器。该仪器具有多种成像功能和卓越的灵敏度，可用于表征荧光和化学荧光凝胶和斑点。这种能力是NIH资助的许多目前正在南大进行的项目(包括但不限于本申请中详细描述的15个项目)所需的，而西北大学或附近其他学术机构无法提供这种能力。该仪器将被整合到凯克生物物理设施中，这是一个著名的共享设备和技术专长的资源，NU的研究人员一周7天、每天24小时都可以使用。人们对台风成像仪为NU生命科学研究界提供的能力的需求不容忽视：大约40个研究小组每天都将从这种能力中受益；研究项目包括试图了解基因组结构和功能的基本方面、真核细胞分裂和分化的关键信号途径、或各种人类疾病(如亨廷顿病、帕金森病、阿尔茨海默病、多囊肾病、慢性阻塞性肺病)的分子起源，以及旨在针对癌症、不孕症、脑和骨骼疾病开发革命性药物和创新治疗策略的研究项目。