Purchase of a Typhoon Phosphorimager-Fluoroimager for the Keck Biophysics Facilit

描述（由申请人提供）：这是一个建议，以获得最先进的台风荧光成像仪/磷光成像仪作为西北大学研究界的共享仪器。该仪器提供了多功能成像能力和卓越的灵敏度，用于表征荧光和化学荧光凝胶和印迹。这些能力是目前在NU进行的许多NIH资助的项目所需要的（包括但不限于本申请中详细描述的15个项目），并且在西北大学或附近的其他学术机构不可用。 该仪器将被集成在凯克生物物理设施-一个众所周知的共享设备和技术专长资源提供给NU研究人员每天24小时，每周7天的基础上。 台风成像仪为NU生命科学研究界提供的能力的需求无法强调：每天约有40个研究小组将从这种能力中受益;研究项目包括那些寻求了解基因组结构和功能的基本方面，真核细胞分裂和分化的信号通路，或各种人类疾病的分子起源（例如，亨廷顿氏病、帕金森氏病、阿尔茨海默氏病、多囊肾病、慢性阻塞性肺病），以及那些致力于开发革命性药物和创新性治疗策略以治疗癌症、不孕症、脑和骨骼疾病的公司。

DESCRIPTION (provided by applicant): This is a proposal to acquire a state of the art Typhoon Fluoroimager/Phosphoimager as a shared instrument for the Northwestern University research community. This instrument provides versatile imaging capabilities and exceptional sensitivity for characterization of fluorescent and chemifluorescent gels and blots. Such capabilities are required by many NIH-funded projects currently underway at NU (including, but not limited to, the 15 projects described in detail in this application) and are not available at Northwestern or at other nearby academic institutions. The instrument will be integrated in the Keck Biophysics Facility - a well known resource of shared equipment and technical expertise available to NU researchers on a 24 hours a day, 7 days a week basis. The need for the capabilities provided by the Typhoon imager for the NU Life Sciences research community cannot be underscored: about 40 research groups would benefit from such capabilities on a daily basis; research projects include those seeking to understand basic aspects of genomic structure and function, signaling pathways central to eukaryotic cell division and differentiation, or molecular origins of various human diseases (e.g., Huntington's disease, Parkinson's disease, Alzheimer's disease, polycystic kidney disease, chronic obstructive pulmonary disease), as well as those aiming to develop revolutionary drugs and innovative therapeutic strategies for cancer, infertility, and brain and bone disorders.