A High-End 3 Tesla Human MRI Scanner Dedicated to Research

专用于研究的高端 3 特斯拉人体 MRI 扫描仪

• 批准号: 7838694
• 负责人: Xiaohong Joe Zhou
• 金额: $ 293.11万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-18 至 2013-06-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7838694
• 关键词: Advisory Committees; Anatomy; Area; Arts; Award; Biomedical Research; Body Image; Brain; Chicago; Clinical Research; Commit; Development; Discipline; Ensure; Equipment; Functional Imaging; Funding; Future; Generations; Grant; Guidelines; Housing; Human; Illinois; Image; Imaging Techniques; Imaging technology; Magnetic Resonance Imaging; Medicine; Mission; Play; Policy Making; Positioning Attribute; Preparation; Productivity; Research; Research Infrastructure; Resources; Review Committee; Role; Site; Structure; TNFRSF5 gene; Technical Expertise; Technology; United States National Institutes of Health; Universities; college; cost; instrumentation; operation; square foot

DESCRIPTION (provided by applicant): The University of Illinois at Chicago (UIC) requests grant support to purchase a state-of-the- art whole-body 3 Tesla (3T) magnetic resonance imaging (MRI) scanner to perform advanced anatomic, functional, spectroscopic and physiologic imaging for biomedical research. The requested 3T MRI scanner is urgently needed to (a) accommodate a rapidly increasing number of NIH-funded projects, (b) replace an early generation, out-dated, un-upgradable 3T scanner with cutting-edge 3T technologies, and (c) establish the first-ever 3T imaging facility dedicated to research at UIC. The proposed 3T scanner is of paramount importance for UIC to sustain and strengthen its position at the forefront of imaging technology and to ensure successful completion of fifteen active NIH-funded projects (eleven R01's, one P50, one R21, one K24, and one R03) with a total award of $32.6M. The state-of-the-art MRI scanner will also play a pivotal role in our future expansion from brain to body imaging over a broad range of basic, translational, and clinical research areas. Overall, there is a compelling need for a high-end 3T scanner dedicated to research at UIC. The instrumentation requested is a 3T General Electric Discovery MR750 scanner with advanced neuro- and body-imaging capabilities enabled by cutting-edge technologies. The 3T scanner will be utilized as a University-wide resource located in the College of Medicine. At least 2,500 square feet of space is allocated by the University to house the new 3T MRI facility. Substantial infrastructure and technical expertise are already in place for installing, operating and maintaining the 3T scanner. More importantly, UIC and its College of Medicine have committed $1.17M to the proposed new 3T facility to cover space renovation, site preparation, scanner installation, and operation costs. To ensure continued successful operation in the post-award period, a Project Review Committee will be created to allocate the 3T resource according to the NIH guidelines and promote equipment usage while ensuring scientific merit and productivity. In addition, an Advisory Committee will be created to oversee the management of this grant and make policy and strategic decisions. This administrative structure is accompanied by a financial plan that ensures self-supporting in the post-award period. The mission of our 3T imaging facility is to promote the development and synergistic application of MRI techniques to a broad range of biomedical disciplines. The purchase of the new 3T scanner is a critical and significant step to accomplish this mission.

描述（由申请人提供）：伊利诺伊大学芝加哥分校（UIC）请求拨款支持购买最先进的全身3特斯拉（3 T）磁共振成像（MRI）扫描仪，以执行先进的解剖，功能，光谱和生理成像的生物医学研究。迫切需要所要求的3 T MRI扫描仪，以（a）适应NIH资助的项目数量的迅速增加，（B）用尖端的3 T技术取代早期一代、过时的、不可拆卸的3 T扫描仪，以及（c）在UIC建立有史以来第一个专用于研究的3 T成像设施。拟议的3 T扫描仪对于UIC保持和加强其在成像技术前沿的地位以及确保成功完成15个NIH资助的项目（11个R 01，1个P50，1个R21，1个K24和1个R 03）至关重要，总奖金为3260万美元。最先进的MRI扫描仪也将在我们未来从大脑到身体成像的广泛基础，转化和临床研究领域的扩展中发挥关键作用。总的来说，UIC迫切需要一款专门用于研究的高端3 T扫描仪。 要求的仪器是一台3 T通用电气Discovery MR 750扫描仪，具有先进的神经和身体成像能力，采用尖端技术。3 T扫描仪将被用作位于医学院的全校资源。至少2,500平方英尺的空间是由大学分配给房子新的3 T MRI设施。我们已经为安装、操作和维护3 T扫描仪提供了大量基础设施和技术专业知识。更重要的是，UIC及其医学院已承诺为拟议的新3 T设施提供117万美元，以支付空间改造、场地准备、扫描仪安装和运营成本。为了确保在授予后持续成功运行，将成立一个项目审查委员会，根据NIH指南分配3 T资源，并在确保科学价值和生产力的同时促进设备使用。此外，还将设立一个咨询委员会，负责监督这笔赠款的管理，并作出政策和战略决定。这一行政结构附有一项财务计划，确保在授标后期间实现自我维持。 我们的3 T成像设备的使命是促进MRI技术在广泛的生物医学学科中的发展和协同应用。购买新的3 T扫描仪是完成这一使命的关键和重要的一步。

项目成果

Neurofunctional correlates of behavioral inhibition system sensitivity during attentional control are modulated by perceptual load.

• DOI: 10.1016/j.biopsycho.2017.04.015
• 发表时间: 2017-07
• 期刊: Biological psychology
• 影响因子: 2.6
• 作者: Bunford N;Roberts J;Kennedy AE;Klumpp H
• 通讯作者: Klumpp H

Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness.

• DOI: 10.1002/jmri.25463
• 发表时间: 2017-05
• 期刊: Journal of magnetic resonance imaging : JMRI
• 作者: Xiong Y;Zhou XJ;Nisi RA;Martin KR;Karaman MM;Cai K;Weaver TE
• 通讯作者: Weaver TE

The feasibility of quantitative MRI of perivascular spaces at 7T.

• DOI: 10.1016/j.jneumeth.2015.09.001
• 发表时间: 2015-12-30
• 期刊: Journal of neuroscience methods
• 影响因子: 3
• 作者: Cai K;Tain R;Das S;Damen FC;Sui Y;Valyi-Nagy T;Elliott MA;Zhou XJ
• 通讯作者: Zhou XJ

A fractional motion diffusion model for grading pediatric brain tumors.

• DOI: 10.1016/j.nicl.2016.10.003
• 发表时间: 2016
• 期刊: NEUROIMAGE-CLINICAL
• 影响因子: 4.2
• 作者: Karaman, M. Muge;Wang, He;Sui, Yi;Engelhard, Herbert H.;Li, Yuhua;Zhou, Xiaohong Joe
• 通讯作者: Zhou, Xiaohong Joe

Steer-PROP: a GRASE-PROPELLER sequence with interecho steering gradient pulses.

Steer-PROP：带有回波间转向梯度脉冲的 GRASE-PROPELLER 序列。

• DOI: 10.1002/mrm.26898
• 发表时间: 2018
• 期刊: Magnetic resonance in medicine
• 影响因子: 3.3
• 作者: Srinivasan,Girish;Rangwala,Novena;Zhou,XiaohongJoe
• 通讯作者: Zhou,XiaohongJoe