ORAL DESENSITIZATION TO EGG & INDUCTION OF TOLERANCE FOR EGG ALLERGIC CHILDREN
口腔对鸡蛋脱敏
基本信息
- 批准号:7718191
- 负责人:
- 金额:$ 2.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-03-01 至 2009-02-28
- 项目状态:已结题
- 来源:
- 关键词:AllergicAllergy to eggsBlindedChildComputer Retrieval of Information on Scientific Projects DatabaseDailyDoseEgg ProteinsEgg WhiteEnd PointFundingGrantImmunologicsImmunotherapyIngestionInstitutionMaintenanceMeasuresOralOral AdministrationPhasePlacebo ControlPlacebosProspective StudiesRandomizedRelative (related person)ResearchResearch PersonnelResourcesSafetySolidSourceTimeUnited States National Institutes of HealthWeekdaydesensitizationegg
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This is a multi-center randomized, placebo-controlled (and blinded) through 40 weeks, prospective study to investigate the safety and immunologic effects of egg oral immunotherapy for egg allergy.
The primary endpoint will be to determine in egg allergic children, whether relative to placebo, daily oral administration of egg white solid escalated over a 10-month period to a maximum of 2000mg/day, increases tolerance as measured by an OFC performed 4-6 weeks after therapy discontinuation by the two year time point. Secondary endpoints include:
1) The percentage of subjects who can tolerate 5 gms of egg white solid after egg OIT following the desensitization phase of the study.
2) The percentage of subjects who tolerate the initial day escalation to 50 mg of egg OIT.
3) The percentage of subjects who achieve the 2 gm maintenance dose of egg OIT during the desensitization phase of the study.
Hypothesis: Daily ingestion of small amounts of egg protein will desensitize egg-allergic children (increasing their ability to ingest egg while on therapy) and after long term treatment will induce tolerance to egg (a permanent ability to ingest egg while off therapy).
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SCOTT H SICHERER其他文献
SCOTT H SICHERER的其他文献
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{{ truncateString('SCOTT H SICHERER', 18)}}的其他基金
Precision Allergy Thresholds With Accurate immunotherapy Selection -Clinical Core
精确的过敏阈值和准确的免疫疗法选择 - 临床核心
- 批准号:
10635813 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
ChAllenging to Foods with Escalating ThrEsholds for ReducIng Food Allergy
挑战食品,提高减少食物过敏的阈值
- 批准号:
10415891 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
Mount Sinai's COFAR Clinical Research Unit and Clinical Trial (The "ADVANCE" Trial).
西奈山的 COFAR 临床研究单位和临床试验(“ADVANCE”试验)。
- 批准号:
10589847 - 财政年份:2017
- 资助金额:
$ 2.4万 - 项目类别:
Mount Sinai's COFAR Clinical Research Unit and Clinical Trial (The "ADVANCE" Trial).
西奈山的 COFAR 临床研究单位和临床试验(“ADVANCE”试验)。
- 批准号:
10399723 - 财政年份:2017
- 资助金额:
$ 2.4万 - 项目类别:
Immune Mechanisms, Genetic and Environmental Factors Influencing Outcomes
影响结果的免疫机制、遗传和环境因素
- 批准号:
9305646 - 财政年份:2016
- 资助金额:
$ 2.4万 - 项目类别:
Immune Mechanisms, Genetic and Environmental Factors Influencing Outcomes
影响结果的免疫机制、遗传和环境因素
- 批准号:
8022453 - 财政年份:2010
- 资助金额:
$ 2.4万 - 项目类别:
ORAL DESENSITIZATION TO EGG AND SUBSEQUENT INDUCTION OF TOLERANCE
口腔对鸡蛋脱敏并随后诱导耐受
- 批准号:
7953701 - 财政年份:2009
- 资助金额:
$ 2.4万 - 项目类别:














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