SURGERY, PSYCHOLOGICAL FACTORS, BLOOD CLOTTING FACTORS IN WOMEN GYN PROCEDURES

女性妇科手术中的手术、心理因素、凝血因素

• 批准号: 7718196
• 负责人: Sara Higgins
• 金额: $ 0.11万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718196
• 关键词: Attenuated; Blood; Blood Clot; Blood Coagulation Factor; Blood coagulation; Cancer Patient; Coagulation Process; Computer Retrieval of Information on Scientific Projects Database; Distress; Emotional; Event; Fibrin fragment D; Fibrinogen; Funding; Grant; Institution; Literature; Malignant Neoplasms; Malignant neoplasm of ovary; Medical; Morbidity - disease rate; Operative Surgical Procedures; Patients; Plasminogen Activator Inhibitor 1; Postoperative Period; Procedures; Psychological Factors; Psychological Stress; Purpose; Reporting; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Source; Sudden Death; Thromboembolism; Thrombosis; Tumor Debulking; United States National Institutes of Health; Venous; Woman; coping; emotional distress; experience; psychobiology; psychologic; psychological distress; reproductive; response; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Women with ovarian cancer, the most deadly cancer of the reproductive tract, are at a heightened risk for developing a venous thromboembolism (VTE) after surgical debulking, the primary treatment for virtually all patients. The experience of such a VTE event can result in significant morbidity and sudden death, yet remains largely unpredictable. Evidence from the experimental psychobiology literature has demonstrated effects of psychological stress on coagulation factors, but the implications of this emerging research has yet to be determined in surgery patients. Given the high levels of distress reported in ovarian cancer patients prior to surgery, it is important to determine the role distress may have on coagulation factors that increase risk of VTE. Objective/hypothesis: The purpose of the proposed research is to prospectively assess the effect of preoperative psychological distress on postoperative coagulation factors. It is hypothesized that both higher levels of emotional distress immediately prior to surgery (e.g., emotional upset) as well as background psychological variables (e.g., coping style) will predict heightened coagulation responses to surgery (i.e., increased blood levels of D-Dimer, fibrinogen, PAI-1), controlling for demographic and medical variables. It is further hypothesized that while negative psychological variables may enhance to coagulation response to surgery, positive psychological variables may attenuate it. The study will also statistically explore possible unique and combined effects of state, trait and background psychological variables on postoperative blood levels of thrombosis risk factors.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 背景资料： 卵巢癌是最致命的生殖道癌症，女性在手术减积后发生静脉血栓栓塞（VTE）的风险更高，手术减积是几乎所有患者的主要治疗方法。 这种VTE事件的经历可能导致显著的发病率和猝死，但在很大程度上仍然是不可预测的。来自实验心理生物学文献的证据已经证明了心理应激对凝血因子的影响，但这一新兴研究的意义还有待于在手术患者中确定。考虑到卵巢癌患者在手术前报告的高水平的痛苦，确定痛苦可能对增加VTE风险的凝血因子的作用是很重要的。 目的/假设： 本研究的目的是前瞻性评估术前心理困扰对术后凝血因子的影响。 据推测，手术前较高水平的情绪困扰（例如，情绪不安）以及背景心理变量（例如，应对方式）将预测对手术的高凝反应（即，D-二聚体、纤维蛋白原、派-1的血液水平升高），控制人口统计学和医学变量。 进一步假设，虽然消极的心理变量可能会增强对手术凝血反应，积极的心理变量可能会减弱它，本研究还将统计学探讨可能的独特和综合影响的状态，特质和背景心理变量对术后血栓形成危险因素的血液水平。