EFFECTS OF GROWTH HORMONE ON METABOLISM AND SATIATION IN PRADER-WILLI SYNDROME

生长激素对普瑞德威利综合征代谢和饱足感的影响

基本信息

  • 批准号:
    7717075
  • 负责人:
  • 金额:
    $ 7.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-12-01 至 2008-11-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prader-Willi Syndrome is a neurobehavioral syndrome whose clinical features include neonatal failure-to-thrive, a distinct behavioral phenotype, cognitive impairment, hypotonia, hyperphagia and morbid obesity. This syndrome is the most commonly recognized genetic cause of obesity. It has been suggested that the hyperphagia is secondary to altered hypothalamic function, which is a consequence of the genetic alterations that characterize this condition. Children with Prader-Willi syndrome have evidence of a growth hormone deficiency secondary to hypothalamic dysfunction. Studies have shown that children with Prader-Willi syndrome treated with GH have a decrease in fat mass and an increase in lean body mass, an increase in growth velocity and in resting energy expenditure. It is unknown if treatment of children with Prader-Willi syndrome with GH causes changes in the hypothalamus, or if the effects are peripheral. This study will investigate the benefits of GH on hypothalamic recognition of hunger and satiety, as well as on the basal metabolic rate and body composition of PWS individuals. We will compare the neuroanatomical correlates of hunger and satiation using functional MRI on PWS patients before and one year after GH treatment. In addition, we will use normal weight siblings and non-PWS obese individuals as additional comparison groups. Blood will be drawn to determine various hormonal and neurotransmitter levels at times correlating with hunger and satiety in these individuals. Basal metabolic rate and body composition via dual energy X-ray absorptiometry; will be assessed for all individuals, and will be reevaluated in PWS subjects one year after treatment with GH.
该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金, 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说,它不一定是研究者的机构。 普瑞德威利综合征是一种神经行为综合征,其临床特征包括新生儿发育不良、独特的行为表型、认知障碍、肌张力低下、食欲过盛和病态肥胖。这种综合征是最常见的肥胖遗传原因。有人认为,食欲过盛是继发于下丘脑功能改变的,而下丘脑功能改变是这种疾病特征性基因改变的结果。患有普瑞德威利综合征的儿童有继发于下丘脑功能障碍的生长激素缺乏的证据。研究表明,接受 GH 治疗的普瑞德威利综合征儿童的脂肪量减少,瘦体重增加,生长速度加快,静息能量消耗增加。目前尚不清楚用 GH 治疗患有普瑞德威利综合征的儿童是否会引起下丘脑的变化,或者影响是否是外周的。 这项研究将调查 GH 对下丘脑对饥饿和饱腹感的识别以及 PWS 个体的基础代谢率和身体成分的益处。我们将使用功能性 MRI 对 PWS 患者在 GH 治疗前和治疗后一年来比较饥饿和饱腹感的神经解剖学相关性。此外,我们将使用正常体重的兄弟姐妹和非 PWS 肥胖个体作为额外的对照组。将抽取血液来测定有时与这些人的饥饿和饱腹感相关的各种激素和神经递质水平。通过双能 X 射线吸收测定法测定基础代谢率和身体成分;将对所有个体进行评估,并将在 GH 治疗一年后对 PWS 受试者进行重新评估。

项目成果

期刊论文数量(0)
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JENNIFER L MILLER其他文献

JENNIFER L MILLER的其他文献

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{{ truncateString('JENNIFER L MILLER', 18)}}的其他基金

Neuroanatomic Studies in Prader-Willi Syndrome and Early-onset Obesity
普瑞德威利综合征和早发性肥胖的神经解剖学研究
  • 批准号:
    8050081
  • 财政年份:
    2008
  • 资助金额:
    $ 7.1万
  • 项目类别:
EFFECTS OF GROWTH HORMONE ON METABOLISM AND SATIATION IN PRADER-WILLI SYNDROME
生长激素对普瑞德威利综合征代谢和饱足感的影响
  • 批准号:
    7950705
  • 财政年份:
    2008
  • 资助金额:
    $ 7.1万
  • 项目类别:
Neuroanatomic Studies in Prader-Willi Syndrome and Early-onset Obesity
普瑞德威利综合征和早发性肥胖的神经解剖学研究
  • 批准号:
    7471753
  • 财政年份:
    2008
  • 资助金额:
    $ 7.1万
  • 项目类别:
Neuroanatomic Studies in Prader-Willi Syndrome and Early-onset Obesity
普瑞德威利综合征和早发性肥胖的神经解剖学研究
  • 批准号:
    7783792
  • 财政年份:
    2008
  • 资助金额:
    $ 7.1万
  • 项目类别:
Neuroanatomic Studies in Prader-Willi Syndrome and Early-onset Obesity
普瑞德威利综合征和早发性肥胖的神经解剖学研究
  • 批准号:
    8249473
  • 财政年份:
    2008
  • 资助金额:
    $ 7.1万
  • 项目类别:
Neuroanatomic Studies in Prader-Willi Syndrome and Early-onset Obesity
普瑞德威利综合征和早发性肥胖的神经解剖学研究
  • 批准号:
    7578209
  • 财政年份:
    2008
  • 资助金额:
    $ 7.1万
  • 项目类别:
FUNCTIONAL MAGNETIC RESONANCE IMAGING OF REDUCED SATIETY IN PWS AND OBESITY
PWS 饱腹感降低和肥胖的功能磁共振成像
  • 批准号:
    7717098
  • 财政年份:
    2007
  • 资助金额:
    $ 7.1万
  • 项目类别:
EFFECTS OF GROWTH HORMONE ON METABOLISM AND SATIATION IN PRADER-WILLI SYNDROME
生长激素对普瑞德威利综合征代谢和饱足感的影响
  • 批准号:
    7605445
  • 财政年份:
    2006
  • 资助金额:
    $ 7.1万
  • 项目类别:
EFFECTS OF GROWTH HORMONE ON METABOLISM AND SATIATION IN PRADER-WILLI SYNDROME
生长激素对普瑞德威利综合征代谢和饱足感的影响
  • 批准号:
    7374640
  • 财政年份:
    2005
  • 资助金额:
    $ 7.1万
  • 项目类别:
EFFECTS OF GROWTH HORMONE ON METABOLISM AND SATIATION IN PRADER-WILLI SYNDROME:
生长激素对普瑞德威利综合征新陈代谢和饱足感的影响:
  • 批准号:
    7202943
  • 财政年份:
    2004
  • 资助金额:
    $ 7.1万
  • 项目类别:

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