CORRELATION OF MARKERS OF METABOLIC CONTROL WITH LONG-TERM COMPLICATIONS IN GSD

代谢控制标志物与 GSD 长期并发症的相关性

• 批准号: 7717114
• 负责人: David Daniel Weinstein
• 金额: $ 14.2万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7717114
• 关键词: Age; Anemia; Biochemical; Carcinoma; Clinical; Computer Retrieval of Information on Scientific Projects Database; Development; Diagnosis; Disease; Funding; Generations; Glycogen Storage Disease; Grant; Hepatic; Institution; Kidney; Metabolic Control; Natural History; Patients; Population; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; adenoma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This natural history study is necessary to understand glycogen storage disease as people diagnosed with this disease age. Since the treatment for glycogen storage disease was first implemented approximately 30 years ago, the first generation of patients is now surviving into adulthood. It is important to follow these patients and assess the status of the population. While clinical advances have resulted in amelioration of the biochemical abnormalities in the glycogen storage diseases, long-term complications continue to occur. This study will attempt to understand the role of metabolic control on the development of complications. In particular, the effect of metabolic control on hepatic adenoma formation, hepatocelluar carcinoma development, renal complications, and anemia will be assessed.

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