Physical activity intervention co-created and pilot tested with African American Colorectal Cancer Survivors

与非裔美国结直肠癌幸存者共同创建和试点测试身体活动干预措施

• 批准号: 10095200
• 负责人: Rachel Hirschey
• 金额: $ 15.92万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-03 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10095200
• 关键词: Accelerometer; Address; Adoption; Advanced Development; African American; Award; Biological Markers; Cancer Survivor; Cause of Death; Characteristics; Clinic; Clinical; Colorectal Cancer; Control Groups; Data; Development; Diagnosis; Discrimination; Environment; Ethnic group; Fatigue; Feedback; Foundations; Functional disorder; Future; Goals; Habits; Health; Health Promotion; Healthcare Systems; Individual; Inflammation; Intervention; Interview; Intestines; Knowledge; Low income; Malignant Neoplasms; Measures; Mental Depression; Meta-Analysis; Neighborhoods; Oncology; Outcome; Outcome Measure; Pain; Participant; Pathway interactions; Physical activity; Pilot Projects; Population; Poverty; Predictive Factor; Provider; Psychological reinforcement; Publishing; Quality of life; Race; Randomized; Reach, Effectiveness, Adoption, Implementation, and Maintenance; Recommendation; Reporting; Research; Research Personnel; Resources; Sampling; Scientist; Self Efficacy; Stress; Surveys; Survivors; Symptoms; Tablets; Technology; Testing; Text Messaging; Time; Training; Treatment Protocols; Treatment Side Effects; Variant; Walking; cancer care; cancer health disparity; cancer therapy; cancer type; care systems; chemotherapy; colorectal cancer treatment; cost; effectiveness testing; efficacy outcomes; efficacy testing; exercise intervention; expectation; experience; fitbit; group intervention; high risk; implementation design; implementation intervention; improved; interest; malignant breast neoplasm; mortality; multi-component intervention; novel strategies; pain symptom; post intervention; programs; psychosocial; racial and ethnic; recruit; response; side effect; skills; social culture; standard care; therapy design; vigorous intensity

Project Summary/Abstract The long-term objective of this research is to improve physical activity among populations experiencing cancer disparities. The goal of this training award is to: (1) deliver a multicomponent, culturally-targeted, technology- delivered, scalable intervention to increase physical activity among African American colorectal cancer survivors; while advancing the development of a new investigator, with a program of research focused on increasing physical activity and decreasing cancer disparities. Specific aims are to: (1) co-create, with AA CRC survivors who engaged in physical activity throughout cancer treatment, culturally targeted narrative videos to increase physical activity knowledge, self-efficacy, outcome expectations, habits and enjoyment; (2) pilot test the intervention to assess reach, effectiveness, adoption, implementation, and maintenance and; and (3) measure outcomes at baseline, 3- and 9-months post baseline. Outcomes include: psychosocial constructs related to physical activity engagement (knowledge, self-efficacy, outcome expectations, enjoyment, habits); physical activity (average daily steps, weekly minutes of moderate-vigorous intensity activity); symptoms (pain, fatigue, depression, bowel dysfunction); and inflammation biomarkers that may explain the pathways through which physical activity impacts cancer outcomes. First, a qualitative exploratory approach will be used to interview 20 African American colorectal cancer survivors. Together with a subset of interested participants a multi-component intervention to increase physical activity among African American colorectal cancer survivors will be created. Next, an additional 72 participants will be recruited to conduct a pilot two-group, randomized repeated measures study to assess Reach, Effectiveness, Adoption, Implementation and Maintenance (RE- AIM) of the intervention. Feasibility of collecting survey and biomarker data at baseline, 3 and 9 months later will be assessed. These timepoints will facilitate exploration of changes pre- and post-intervention, and to determine if effects are maintained 6 months after completing the intervention and chemotherapy. Time since last chemotherapy will be controlled for in all analyses to account for variations in treatment schedules.

项目总结/摘要 这项研究的长期目标是改善患有癌症的人群的身体活动 差距。该培训奖的目标是：（1）提供一个多成分的，文化针对性的，技术- 提供可扩展的干预措施，以增加非裔美国人结直肠癌患者的体力活动 幸存者;同时推进一个新的调查员的发展，研究计划的重点是 增加身体活动和减少癌症差异。具体目标是：（1）与AA CRC共同创建 在整个癌症治疗过程中从事体力活动的幸存者，有文化针对性的叙事视频， 增加身体活动知识、自我效能、结果期望、习惯和享受;（2）试点测试 评估覆盖范围、有效性、采用、实施和维护的干预措施;以及（3） 测量基线、基线后3个月和9个月的结局。结果包括：社会心理结构 与身体活动参与相关（知识、自我效能、结果预期、享受、习惯）; 身体活动（平均每日步数，每周中等强度活动的分钟数）;症状（疼痛， 疲劳、抑郁、肠功能障碍）;以及炎症生物标志物，这些生物标志物可以解释通过 哪些身体活动会影响癌症的结果。首先，将采用定性探索方法， 采访了20名非裔美国人结直肠癌幸存者。与一部分感兴趣的参与者一起， 多成分干预增加非裔美国人结直肠癌幸存者的体力活动 将被创建。接下来，将招募额外的72名参与者进行试点两组，随机 重复措施研究，以评估覆盖范围、有效性、采用、实施和维护（RE- 目的）的干预。在基线、3个月和9个月后收集调查和生物标志物数据的可行性 将被评估。这些时间点将有助于探索干预前后的变化， 确定在完成干预和化疗后6个月效果是否维持。以来 在所有分析中将对末次化疗进行控制，以考虑治疗方案的变化。