Molecular Mechanisms of HFpEF-associated Atrial Fibrillation

HFpEF 相关心房颤动的分子机制

基本信息

  • 批准号:
    10097363
  • 负责人:
  • 金额:
    $ 40.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-01-01 至 2024-12-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY It is said that heart failure with preserved ejection fraction (HFpEF) is the single greatest unmet need in cardiovascular medicine. Patients with HFpEF are uniquely predisposed to atrial fibrillation (AF), a common rhythm disturbance that is associated with worse clinical outcomes. In other words, AF and HFpEF co-segregate, substantially exacerbate one another, and represent a prevalent and unique clinical challenge without effective therapies. Metabolic diseases, such as obesity, diabetes, and hypertension, are common comorbidities for both HFpEF and AF, suggesting that metabolic disturbance serves as a common mechanism underlying both conditions. We recently developed and validated a uniquely informative murine model of HFpEF and unveiled mechanisms never reported previously in heart disease. These animals are predisposed to AF, just as are patients with HFpEF. Further, we have collected preliminary data revealing that AMPK signaling is impaired in the atria of these mice and is associated with atrial remodeling similar to changes observed in HFpEF patients. If confirmed, this is a novel mechanism of disease-triggered AF, one that does not involve tissue fibrosis, etc. Here, we propose to test the central hypothesis that impaired AMPK signaling contributes to pathological atrial remodeling in HFpEF, and modulating this pathway will attenuate atrial pathology and AF predisposition in HFpEF. Specifically, we will delineate the role of AMPK in HFpEF-associated atrial structural and electrical remodeling, focusing on atrial myocyte hypertrophy, Cx40-mediated atrial myocyte communication, and HCN4-mediated ectopic automaticity. In a translational aim, we will determine the effect of AMPK activation on attenuating atrial remodeling and AF predisposition
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

THOMAS G GILLETTE其他文献

THOMAS G GILLETTE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('THOMAS G GILLETTE', 18)}}的其他基金

ETS2-dependent control in cardiomyocyte ischemia/reperfusion injury
ETS2 依赖性控制心肌细胞缺血/再灌注损伤
  • 批准号:
    10501545
  • 财政年份:
    2022
  • 资助金额:
    $ 40.92万
  • 项目类别:
ETS2-dependent control in cardiomyocyte ischemia/reperfusion injury
ETS2 依赖性控制心肌细胞缺血/再灌注损伤
  • 批准号:
    10674020
  • 财政年份:
    2022
  • 资助金额:
    $ 40.92万
  • 项目类别:
Molecular Mechanisms of HFpEF-associated Atrial Fibrillation
HFpEF 相关心房颤动的分子机制
  • 批准号:
    10545081
  • 财政年份:
    2021
  • 资助金额:
    $ 40.92万
  • 项目类别:
Molecular Mechanisms of HFpEF-associated Atrial Fibrillation
HFpEF 相关心房颤动的分子机制
  • 批准号:
    10322371
  • 财政年份:
    2021
  • 资助金额:
    $ 40.92万
  • 项目类别:

相似海外基金

The role of auditory-motor coupling in musicians' speech perception in noise: Modulation of alpha rhythm desynchronization by transcranial direct current stimulation
听觉-运动耦合在音乐家噪声中言语感知中的作用:经颅直流电刺激调节阿尔法节律去同步
  • 批准号:
    542667-2019
  • 财政年份:
    2019
  • 资助金额:
    $ 40.92万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Master's
Neuronal mechanisms of the propofol-induced alpha rhythm
异丙酚诱导α节律的神经机制
  • 批准号:
    18K09731
  • 财政年份:
    2018
  • 资助金额:
    $ 40.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Neuronal mechanisms of propofol-induced alpha rhythm in rat cerebral cortex
异丙酚诱导大鼠大脑皮层α节律的神经机制
  • 批准号:
    25463150
  • 财政年份:
    2013
  • 资助金额:
    $ 40.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Modulation of Neural Representation & Perception by Thalamocortical Alpha Rhythm
神经表征的调节
  • 批准号:
    7546851
  • 财政年份:
    2008
  • 资助金额:
    $ 40.92万
  • 项目类别:
Modulation of Neural Representation & Perception by Thalamocortical Alpha Rhythm
神经表征的调节
  • 批准号:
    7920067
  • 财政年份:
    2008
  • 资助金额:
    $ 40.92万
  • 项目类别:
The role of alpha rhythm in sensory input control during selective attention
阿尔法节律在选择性注意过程中感觉输入控制中的作用
  • 批准号:
    385480795
  • 财政年份:
  • 资助金额:
    $ 40.92万
  • 项目类别:
    Research Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了