HIV and Aging SWG

项目摘要/摘要 艾滋病毒与老龄化SWG(SWG_1) 哈佛大学艾滋病研究中心(HU CFAR)艾滋病毒与老龄化的长期目标 科学工作组(SWG)将与波士顿胡椒老年美国人独立组织合作 中心(也称为波士顿胡椒中心)1)建立并启用互动、社区参与的网络，以 加速发现人类免疫和身体功能下降的机制和生物标志物 老龄化与艾滋病毒(PLWH)，2)创建资源基础设施，以支持与以下相关的跨学科提案 艾滋病毒和老龄化，以及3)指导早期职业调查人员(ECI)。这些目标将通过利用 HU CFAR和波士顿胡椒中心拥有独特的临床和基础资源和专业知识。 由于波士顿胡椒中心代表着一个调查财团，该财团专注于多个 机构，这个SWG将催化和支持HU CFAR研究。 艾滋病毒和老龄问题工作组对艾滋病研究办公室的战略计划作出回应，该战略计划列出了 衰老和虚弱是一个高度优先的研究领域，并被我们的社会确定为优先研究领域 顾问委员。目标1将确定并吸引社区成员和调查人员进行研究 关注艾滋病毒与老龄化之间的关系，并召集各种活动，包括成立讲习班和 共同赞助(Pepper和CFAR)研讨会系列，以促进富有成效的互动，并将赞助 市政厅式的会议，以确定公共卫生部门在护理方面的优先研究领域和差距。AIM 2将建造一个 基础设施提供对HU CFAR和胡椒中心的专业知识和资源的访问，以实现 合作研究。核心服务范围将包括身体功能评估(Pepper)和高级 实验室技术核心服务(CFAR)。AIM 3将与HU CFAR开发和 指导核心制定共同赞助的试点赠款，目标是ECI。RFA将强调使用CORE 两个中心的服务，以及鼓励与两个中心的调查人员接触，并使用 教师实验室中的资源。我们将创建一个内部拨款审查流程，以提供指导和 对ECI发起的提案的反馈。

PROJECT SUMMARY/ABSTRACT HIV and Aging SWG (SWG_1) The long-term objective of the Harvard University Center for AIDS Research (HU CFAR) HIV and Aging Scientific Working Group (SWG) is to collaborate with the Boston Pepper Older Americans Independence Center (a.k.a. Boston Pepper Center) to 1) build and enable an interactive, community-engaged network to accelerate discovery of mechanisms and biomarkers for decline in immune and physical function in people aging with HIV (PLWH), 2) create a resource infrastructure to support cross-disciplinary proposals related to HIV and aging, and 3) mentor Early Career Investigators (ECI). These goals will be achieved by leveraging unique clinical and basic resources and expertise available to the HU CFAR and the Boston Pepper Center. Since the Boston Pepper Center represents a consortium of investigators focused on aging across multiple institutions, this SWG will catalyze and enable HU CFAR research. The HIV and Aging SWG is responsive to the Office of AIDS Research strategic plan which lists, “Premature Aging and Frailty” as a high research priority and was identified as a priority research area by our community advisory members. Aim 1 will identify and engage community members and investigators with research interests at the interface of HIV and aging and convene activities that include an inaugural workshop and a jointly-sponsored (Pepper and CFAR) seminar series to facilitate productive interactions and will sponsor a town-hall style meeting to identify priority research areas and gaps in care among PLWH. Aim 2 will build an infrastructure to provide access to HU CFAR and Pepper Center expertise and resources to enable collaborative studies. Core service outreach will include physical function assessment (Pepper) and Advanced Lab Technologies Core services (CFAR). Aim 3 will collaborate with the HU CFAR Developmental and Mentoring Core to develop co-sponsored pilot grants that target ECIs. The RFA will emphasize use of core services from both centers, as well as encourage outreach to investigators from both centers and use of resources in faculty laboratories. We will create an internal grant review process to provide guidance and feedback on ECI-initiated proposals.