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Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center

下尿路功能障碍症状延续研究网络 (LURN) 数据协调中心

基本信息

批准号：
10246242
负责人：
Robert M Merion
金额：
$ 12.02万
依托单位：
ARBOR RESEARCH COLLABORATIVE FOR HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-25 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10246242
关键词：
Ancillary Study Bar Codes Biological Biological Assay Biological Markers Bladder Case Report Form Characteristics Charge Clinical Clinical Management Clinical Research Clinical Treatment Clinical Trials Collaborations Communication Communities Complex Consensus Data Data Analyses Data Collection Data Coordinating Center Development Diagnosis Diagnostic Disease Functional disorder Funding Future Goals Human Resources Infrastructure Institutional Review Boards Internist Knowledge Lead Leadership Logistics Lower urinary tract Manuscripts Measurement Measures Modeling Monitor Motor National Institute of Diabetes and Digestive and Kidney Diseases Organ Outcome Participant Patient Care Patient Monitoring Patient Self-Report Patient-Focused Outcomes Patients Performance Phase Phenotype Physiological Pilot Projects Plasma Policies Population Process Publications Reporting Research Research Design Research Personnel Sampling Scientist Secure Self Assessment Sensory Severities Site Subgroup Surveys Symptoms System Testing Time Treatment outcome Urethra Urinary Tract Finding Urinary tract Urodynamics Urologist Woman Work Writing base care outcomes clinical phenotype clinical research site cohort data management design dissemination research expectation experience improved insight instrument lower urinary tract symptoms meetings men novel patient subsets protein biomarkers protocol development quality assurance recruit research study response symposium symptom treatment tertiary care tool treatment response treatment trial urinary web site

项目摘要

Project Summary In the Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN II), the investigators will advance the subtyping of study participants with Lower Urinary Tract Symptoms (LUTS) with the expectation that clinically useful patient subtypes will be identified. Research efforts will include continued analysis of data and biospecimens from LURN I and development of additional, new and novel collaborative studies to further improve our understanding of lower urinary tract dysfunction, both designed to generate findings that may inform future clinical studies (e.g., clinical treatment trials) and ultimately improve clinical management and patient outcomes. Studies will also refine and evaluate the longitudinal performance of clusters identified in LURN I for patient subtyping, including response to treatment. We will incorporate insights from the LURN I organ-based diagnostics pilot study and biomarker pilot studies. We will evaluate the LURN Comprehensive Assessment of Self-reported Urinary Symptoms (CASUS) instrument in populations with lesser severity of LUTS than seen in the tertiary care setting in LURN I. Consistent with the description in the RFA for this second funding cycle of LURN, the primary goal of this proposal is to better define clinical phenotypes of patients with LUTS, to better describe the impact and diversity of symptoms, and to develop new patient-centric tools for improved measurement of clinical symptoms, all with the goals of informing future clinical studies and improving patient care and outcomes. It is anticipated that the network will consist of up to six clinical sites and a single data coordinating center (DCC). The DCC for the LURN study is charged with providing coordination, communications and logistical support, clinical study design, centralized data management, biosample management, quality assurance, and analytical support to the research sites and the NIDDK Project Scientist for all LURN studies. The proposing team is submitting this response to RFA-DK-18-511 to continue as the DCC for the network.

项目总结