Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)

下尿路功能障碍症状研究网络 (LURN) 的扩展

基本信息

项目摘要

DESCRIPTION (provided by applicant): Lower urinary tract dysfunction (LUTD) is common, and its incidence and prevalence are increasing as the population ages. Symptoms of LUTD are costly to diagnose and treat; existing therapeutic interventions are neither highly effective nor durable and have side effects of their own. Not surprisingly, unsatisfactory outcomes from the patient perspective are common. Collectively, these challenges represent important targets of research that are consistent with the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Previous efforts to improve patient reported outcomes (PRO) in this area have relied on incomplete symptom measurement scales and have been hampered by imperfect understanding of the origin and natural history of LUTD. Comprehensive re-evaluation of the symptom universe of LUTD and more precise characterization of patients with symptoms of LUTD (phenotyping) may provide significant new insights, leading ultimately to improved patient lives. The NIDDK-sponsored Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) includes a Data Coordinating Center (DCC) to serve as the project and data management nexus for the network. The purpose of this project is to expand the DCC, and increase the number of clinical sites that will enroll patients with symptoms of LUTD into carefully designed studies. There are three specific aims. The first is to expand the infrastructure of the LURN network to accommodate the addition of three to four clinical sites, plus the anticipated increase in complexity in supporting a larger consortium. The second specific aim is to enhance the collaboration between stakeholders by increasing the number of face-to-face meetings of the Steering Committee from one (currently) to three annually. The third aim is to expand the LURN consortium's patient-reported outcome measurement tools to include development and implementation of computerized adaptive testing.
描述(申请人提供):下尿路功能障碍(LUTD)很常见,其发病率和患病率随着人口老龄化而增加。LUTD的症状诊断和治疗费用高昂;现有的治疗干预措施既不是非常有效也不持久,而且有其自身的副作用。从患者的角度来看,结果不令人满意是常见的,这并不令人惊讶。总体而言,这些挑战代表了与国家糖尿病、消化和肾脏疾病研究所(NIDDK)的使命一致的重要研究目标。以前在这一领域改善患者报告结果(PRO)的努力依赖于不完整的症状测量量表,并因对LUTD的起源和自然历史的不完全了解而受到阻碍。全面重新评估LUTD的症状和更精确地描述LUTD患者的症状(表型)可能会提供重要的新见解,最终改善患者的生活。NIDDK赞助的下尿路功能障碍症状研究网络(LURN)包括一个数据协调中心(DCC),作为该网络的项目和数据管理纽带。该项目的目的是扩大DCC,并增加临床站点的数量,将有LUTD症状的患者纳入精心设计的研究。有三个具体目标。首先是扩大Lurn网络的基础设施,以适应增加三到四个临床站点,以及支持更大财团的预期复杂性增加。第二个具体目标是通过将指导委员会每年面对面会议的次数从一次(目前)增加到三次来加强利益攸关方之间的合作。第三个目标是扩大Lurn联盟的患者报告结果衡量工具,以包括开发和实施计算机化的适应性测试。

项目成果

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Robert M Merion其他文献

Robert M Merion的其他文献

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{{ truncateString('Robert M Merion', 18)}}的其他基金

Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
下尿路功能障碍症状研究网络 (LURN) 的扩展
  • 批准号:
    8585774
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
下尿路功能障碍症状研究网络 (LURN) 的扩展
  • 批准号:
    9067345
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
下尿路功能障碍症状研究网络 (LURN) 的扩展
  • 批准号:
    9296129
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center
下尿路功能障碍症状延续研究网络 (LURN) 数据协调中心
  • 批准号:
    10488066
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
下尿路功能障碍症状研究网络 (LURN) 的扩展
  • 批准号:
    9547580
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
下尿路功能障碍症状研究网络 (LURN) 的扩展
  • 批准号:
    8877506
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center
下尿路功能障碍症状延续研究网络 (LURN) 数据协调中心
  • 批准号:
    10251160
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Continuation of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Data Coordinating Center
下尿路功能障碍症状延续研究网络 (LURN) 数据协调中心
  • 批准号:
    10246242
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
下尿路功能障碍症状研究网络 (LURN) 的扩展
  • 批准号:
    9336639
  • 财政年份:
    2013
  • 资助金额:
    $ 40.6万
  • 项目类别:
Novel Control Group to Expand the Scope of the RELIVE Living Kidney Donor Study
新型对照组扩大了 RELIVE 活体肾脏捐赠者研究的范围
  • 批准号:
    8427235
  • 财政年份:
    2012
  • 资助金额:
    $ 40.6万
  • 项目类别:

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