University of Arizona Cancer Center - Cancer Center Support Grant

项目概要/摘要：总体 位于亚利桑那州图森市的亚利桑那大学癌症中心（UACC）已成为NCI指定的癌症中心。 自1978年以来，中心和综合癌症中心自1990年以来。它是作为一个矩阵中心建立的， 亚利桑那大学（UA），其成员代表43个学院和11个部门。2014年 UACC被提升到相当于学院的地位，直接向高级副总裁报告。 健康科学。在这个时候，安德鲁S。Kraft，MD，被任命为UACC主任。对所有人都有权威 在联合国癌症相关活动中，他带头利用重要的机构支持， 加强方案。这包括最近完成的1亿美元220，000平方英尺的门诊诊所， 凤凰，这将大大提高转化研究，扩大基础研究的空间， 在两年内入住20，000平方英尺，并在2015年期间获得2.32亿美元的机构承诺。 未来五年该中心的功能已通过优化行政和 高级领导基础设施。UACC 2015-2020年战略计划呼吁继续 高度创新和有影响力的团队科学基于四个强大的基石计划：癌症生物学， 癌症成像，治疗发展，癌症预防和控制。战略征聘和 试点供资的重点是团队建设，包括发展方案间合作， 研究进入临床。UACC将继续投资其八个综合共享 提高UACC研究人员在基础、预防、转化和临床方面能力的资源 一个是研究，另一个是发展。临床试验办公室得到加强， 正在支持精准医疗举措。UACC是美国唯一的主要学术癌症中心， 400平方英里的驾驶距离，并致力于为该地区的居民及其直接 亚利桑那州南部的集水区。因此，它的重点是皮肤癌和砷暴露以及 西班牙裔美国人，美洲原住民，老年人和经济弱势群体的需求。它已经设立了一个 强大的国际、国家和区域合作基础设施和外展计划， 跨流行病学，遗传学，表观遗传学，细胞生物学和信号机制的研究，以及 有针对性的干预和未充分研究的生存问题。为了抓住新出现的协同效应， 癌症差异副主任和精准医学和生物信息学副主任 由国家认可的专家创建和填补。UACC强调包容性培训 下一代癌症研究人员在美洲原住民毕业方面取得了明显的成功， 拉丁裔。UACC成员产生的研究的特点是其影响，其相关性， 集水区及其创新。该战略计划建立在已导致1 756例癌症的工作基础上， 在报告所述期间，教科文组织出版了相关出版物，目前有4400万美元的同行评审支持资金。

Project Summary / Abstract: Overall The University of Arizona Cancer Center (UACC) in Tucson, Arizona has been an NCI-designated Cancer Center since 1978 and a Comprehensive Cancer Center since 1990. It was founded as a matrix center within the University of Arizona (UA), and its members represent 43 Colleges and 11 Departments. In 2014, the UACC was elevated to a status equivalent to that of a College, reporting directly to the Senior Vice President of Health Sciences. At this time, Andrew S. Kraft, MD, was appointed Director of the UACC. With authority for all cancer-related activities at the UA, he is spearheading the utilization of the significant Institutional support to enhance the Program. This includes the recently completed $100M 220,000 square foot outpatient clinic in Phoenix, which will greatly enhance translational research, an expansion of basic research space with occupancy of 20,000 square feet within two years, and an Institutional Commitment of $232M dollars over the next five years. The functionality of the Center has been enhanced by optimization of the Administration and Senior Leadership infrastructure. The UACC Strategic Plan for 2015–2020 calls for the continuation of the highly innovative and impactful team science based on four robust cornerstone Programs: Cancer Biology, Cancer Imaging, Therapeutic Development, and Cancer Prevention and Control. Strategic recruitment and pilot funding is focused on team building, including development of inter-programmatic collaborations and movement of research into the clinic. The UACC will continue to invest in its eight integrated Shared Resources that enhance the capabilities of UACC investigators in basic, prevention, translational, and clinical research, and another in development. The Clinical Trials Office has been strengthened, and investments supporting precision medicine initiatives are ongoing. The UACC is the only major academic Cancer Center in a 400 square mile area of driving distance and is committed to serving the residents in this region and its direct catchment area of southern Arizona. Thus, it has a focus on skin cancer and arsenic exposure as well as the needs of Hispanics, Native Americans, the elderly, and the economically disadvantaged. It has established a robust infrastructure of international, national, and regional collaborations and outreach programs together with research spanning epidemiology, genetics, epigenetics, cell biology, and signaling mechanisms, as well as targeted interventions and understudied survivorship issues. To capture the emerging synergies, the positions of Associate Director of Cancer Disparities and Associate Director of Precision Medicine and Bioinformatics have been created and filled by nationally recognized experts. The UACC emphasis on inclusive training of the next generation of cancer researchers has had demonstrable success in graduation of Native American and Latinos. The research generated by UACC members is characterized by its impact, its relevance to the catchment area, and its innovation. The Strategic Plan builds on the work that has resulted in 1,756 cancer- related publications in the reporting period and its current portfolio of $44M in peer-reviewed support.