2010 DNA Damage, Mutation, and Cancer

描述(申请人提供)：2000年，劳伦斯·勒布教授和爱德华·勒克勒教授发起了关于DNA损伤、突变和癌症的戈登会议。这次新会议和2010年会议的目的是关注突变与癌症之间的关系。细胞承受来自内源和外源的DNA损伤，它们已经进化出优雅的机制来修复这种损伤。缺陷或异常的修复会导致突变，从而导致癌症。 2010年DNA损伤、突变和癌症会议将介绍DNA修复、突变和癌症的生化、分子和细胞方面的尖端研究。将涵盖的主题包括DNA损伤的化学和识别，DNA修复的机制，耐受和损伤旁路，构象动力学，DNA修复的表观遗传学，人类癌症的小鼠模型，转录和翻译突变，以及DNA修复作为癌症治疗靶点的使用。受邀的演讲者处于各自领域的前沿，来自不同的学科，包括化学、生物化学、细胞生物学和进化生物学。大会将大力鼓励介绍和讨论未发表的成果。我们还将提供一个平台，让初级调查人员介绍简短的演讲，这些演讲将从摘要中挑选出来。我们期待这次会议上的科学交流将对癌症研究产生重大影响，并导致建立新的多学科合作努力。 2010年戈登DNA损伤、突变和癌症会议将于2010年3月21日至26日在加利福尼亚州文图拉海滩举行。为会议提供资金支持对于实现为会议确定的目标来说是至关重要的。在这项赠款申请中，我们要求为演讲者的旅费、注册费和住宿费提供资金，这将有助于抵消参加这次会议的财政负担，特别是年轻调查人员的经济负担。资金将优先用于本来无法参加会议的发言者、初级调查员发言者，并鼓励妇女和少数群体参加。 与公共健康相关：突变是通过各种机制获得的，包括作用于DNA的DNA聚合酶和其他酶造成的错误，以及不准确的病变旁路。人类癌症是由基因组突变引起的，这些突变发生在关键的生长控制基因、负责基因组维护的基因和基因组的调节区。这次多学科会议的重点是通过介绍和深入讨论从小鼠的病变结构到突变的获得等主题来了解突变的机制。因此，这次会议将为来自几个不同学科的科学家提供一个论坛，让他们参与可能导致我们对突变和人类癌症的理解取得进展的关键讨论。会议还将提供一个论坛，学生、博士后研究员和初级研究人员可以通过正式的科学会议和非正式的互动与知名科学家分享信息。初级调查人员的科学交流和指导都需要外部支持，以邀请演讲者旅行，并鼓励初级调查人员、妇女和少数族裔的参与。

DESCRIPTION (provided by applicant): The Gordon Conference on DNA Damage, Mutation, and Cancer was initiated in 2000 by Professors Lawrence Loeb and Edward Loechler. The purpose of this new conference and the 2010 conference is to focus on the relationship between mutations and cancer. Cells sustain DNA damage from both endogenous and external sources and they have evolved elegant machinery to repair this damage. Deficient or aberrant repair results in mutations that can lead to cancer. The 2010 conference on DNA Damage, Mutation, and Cancer will present cutting edge research into biochemical, molecular, and cellular aspects of DNA repair, mutagenesis, and cancer. Topics that will be covered include chemistry and recognition of DNA damage, mechanisms of DNA repair, tolerance, and lesion bypass, conformational dynamics, epigenetics of DNA repair, mouse models of human cancer, transcriptional and translational mutagenesis, and the use of DNA repair as a target for cancer therapy. The invited speakers, who are at the forefront of their fields, come from a variety of disciplines including chemistry, biochemistry, cell biology, and evolutionary biology. The conference will strongly encourage the presentation and discussion of unpublished results. We will also provide a platform for junior investigators to present short talks and these will be selected from the abstracts. We expect that the scientific exchange at the conference will impact cancer research in significant ways and result in establishing new multi-disciplinary collaborative efforts. The 2010 Gordon Conference on DNA Damage, Mutation, and Cancer will be held in Ventura Beach, California from March 21-26, 2010. Awarded funding support for the meeting is critically necessary in order to achieve the goals set forth for the conference. In this grant application, we are requesting funding for travel, registration, and accommodation expenses for speakers that will assist in offsetting the financial burden of participating in this meeting, especially for young investigators. Funding priorities will be for speakers who would otherwise be unable to participate in the meeting, junior investigator speakers, and to encourage the participation of women and minorities. PUBLIC HEALTH RELEVANCE: Mutations are acquired by a variety of mechanisms, including errors made by DNA polymerases and other enzymes that act on DNA, and by inaccurate lesion bypass. Human cancer results from mutations in the genome and these mutations occur in key growth control genes, genes that function in genome maintenance, and regulatory regions of the genome. The focus of this multidisciplinary conference is to understand the mechanisms of mutagenesis through the presentation and in-depth discussion of topics that range from lesion structure to acquisition of mutations in mice. Therefore, this meeting will provide a forum for scientists from several different disciplines to engage in key discussions that are likely to lead to advances in our understanding of mutagenesis and human cancer. The meeting will also provide a forum in which students, postdoctoral fellows, and beginning investigators can share information with established scientists through formal scientific sessions and informal interactions. Both the scientific cross-fertilization and mentoring of junior investigators require external support for invited speaker travel, and to encourage the participation of junior investigators, women, and minorities.