Objectively and dynamically measured human behaviors and their role in myopia development
客观、动态地测量人类行为及其在近视发展中的作用
基本信息
- 批准号:10247492
- 负责人:
- 金额:$ 17.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeAnimal ModelAnimalsAttentionAwardBehaviorBehavioralBinocular VisionBlindnessCellular PhoneChildChildhoodCircadian RhythmsClinicalDataData AnalysesData AnalyticsDevelopmentDevicesDoctor of PhilosophyDoseEconomic BurdenEconomicsEducationEnvironmentEnvironmental Risk FactorEyeFacultyFar EastFemaleFutureGenderGeneticGoalsGoldGrantGrowthHeadHumanImageInfluentialsInvestigationKnowledgeLengthLightLightingLongitudinal StudiesMeasuresMentorsMeta-AnalysisMethodsMissionMyopiaNatureOptometristOptometryParentsPatternPlayPoliciesPopulation StudyPrevalencePublic HealthQuality of lifeQuestionnairesRefractive ErrorsReportingResearchResearch TrainingRiskRisk FactorsRoleSavingsSchoolsSeasonsSeveritiesSex DifferencesStatistical Data InterpretationTechnical ExpertiseTechniquesTechnologyThinkingTimeTrainingVariantVideo RecordingVisionVision researchVisualVisual impairmentWorkWritingbaseburden of illnesscareercareer developmentclinical decision-makingclinical practiceevidence baseexperiencegazegenome wide association studyimprovedinterestluminancemalemembermodifiable risknovelresearch and developmentsensorsexstudent mentoringtoolvision scienceyoung adult
项目摘要
Candidate: Dr. Harb, a pediatric optometrist, has an overarching long-term goal of pursuing research that is
translatable to clinical practice. In addition to pursuing a PhD in Vision Science, the shorter-term goals of
additional training are to acquire: (1) an in-depth knowledge of current thinking in myopia development and
treatment options from mechanistic and clinical perspectives, (2) proficiency in advanced statistical analyses to
allow for novel data analysis, and (3) diverse career development opportunities. Environment: The UC
Berkeley School of Optometry offers a rich environment for vision research, with approximately 30 Vision
Science faculty members covering diverse research backgrounds. Dr. Harb’s mentors (Wildsoet, Levi, Banks)
have demonstrated significant support towards her research and career development and Dr. Harb’s
comprehensive training plan (grant/scientific writing, technical skills, clinical duties, coursework, mentoring
students and professional activities) will provide ample career development during the award period.
Research: The recent rapid rise in the prevalence of myopia is incompatible with a genetic explanation,
leading to increased interest in environmental factors. However, a significant deficiency in studies attempting to
quantify the visual environment has been the reliance on questionnaires, which are both inaccurate (Ostrin
2015, Chan 2016) and limited in their ability to capture potentially critical details such as the dosing of
exposure, which has proven influential in animal studies (Lan 2014). Therefore, it is plausible that as yet un-
discovered aspects of the visual environment and/or human behaviors, not captured in questionnaires will
prove to be strong risk factors for the development of myopia. The overall objective of this application is to
exploit objective technological methods and dynamic data analytics to assess human indoor/outdoor
behaviors, including nearwork, to explore associations with the presence and/or magnitude of myopia and
influence of gender/sex. Specific aims of the proposed project are: 1) To create a set of tools using objective
technologies that integrate dynamic analytic techniques to capture key aspects of human behavior of potential
relevance to myopia development, 2) To investigate the impact of nearwork behaviors on myopia presence,
magnitude and progression in young adults and children and 3) To investigate the impact of indoor/outdoor
behaviors on myopia presence, magnitude and progression in young adults and children. These aims will be
accomplished through the utilization of several objective, technological-based methods and dynamic data
analysis. The study will be conducted in both young adults and children, and will inform the rationale for a
future multi-centered longitudinal study investigating behaviors in children prior to the onset of myopia (in a
future R01 proposal). Myopia is a leading cause of preventable blindness, with significant economic and
disease burden. Thus, this project is in line with NEI’s mission to promote research that ‘leads to sight-saving
treatments, reduces visual impairment and blindness, and improves the quality of life for people of all ages.’
候选人:哈布博士是一名儿科验光师,他有一个重要的长期目标,那就是从事研究
可翻译成临床实践。除了攻读视觉科学博士学位外,短期目标是
额外的培训将获得:(1)对近视发展和发展的当前思维的深入知识
从机制和临床角度的治疗选择,(2)熟练掌握高级统计分析
允许进行新颖的数据分析,以及(3)提供多样化的职业发展机会。环境:统一通信
伯克利验光学院为视力研究提供了丰富的环境,拥有约30个视力
科学教员涵盖了不同的研究背景。哈布博士的导师(Wildsoet、Levi、Banks)
对她的研究和职业发展以及哈布博士的
综合培训计划(补助金/科学写作、技术技能、临床职责、课程作业、指导
学生和专业活动)将在获奖期间提供充分的职业发展。
研究:近视患病率最近的快速上升与遗传解释不相容,
导致人们对环境因素的兴趣增加。然而,试图在研究中发现的一个重大缺陷是
量化视觉环境一直依赖问卷调查,这两者都不准确(Ostrin
2015,Chan 2016),并且它们捕获潜在关键细节的能力有限,例如剂量
暴露,这在动物研究中已被证明具有影响力(Lan 2014)。因此,有可能到目前为止-
调查问卷中未记录的视觉环境和/或人类行为的已发现方面将
证明是近视发生的强烈危险因素。此应用程序的总体目标是
利用客观的技术方法和动态数据分析来评估室内/室外人体
行为,包括近距离工作,以探索与近视的存在和/或程度和
性别/性别的影响。拟议项目的具体目标是:1)创建一套使用目标的工具
集成动态分析技术以捕捉人类潜在行为的关键方面的技术
与近视发展的相关性,2)调查近距离工作行为对近视存在的影响,
在年轻人和儿童中的大小和进展以及3)调查室内/室外
青少年和儿童近视的存在、程度和进展的行为。这些目标将是
通过使用几种客观的、基于技术的方法和动态数据来实现
分析。这项研究将在年轻人和儿童中进行,并将为
未来的多中心纵向研究,调查儿童近视发病前的行为(在
未来的R01提案)。近视是可预防失明的主要原因,具有显著的经济和
疾病负担。因此,这个项目符合NEI的使命,即促进研究,使人们能够保护视力
治疗,减少视力障碍和失明,并提高所有年龄段的人的生活质量。
项目成果
期刊论文数量(0)
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会议论文数量(0)
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Elise N Harb的其他文献
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