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Project 2: Reaching Cancer Survivors with Distance-delivered Support for Physical Activity Behavior Change (REACH)

项目 2：为癌症幸存者提供远程身体活动行为改变支持 (REACH)

基本信息

批准号：
10247781
负责人：
LAURA Q ROGERS
金额：
$ 5.02万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10247781
关键词：
Accelerometer Accountability Address African American Aftercare Age Aging Attention Behavior Behavior Therapy Biological Markers Breast Cancer survivor Cancer Intervention Cancer Survivor Cancer Survivorship Caring Cessation of life Confidence Intervals Counseling Diagnosis Dissemination and Implementation Electronic Mail Elements Enrollment Exercise Facebook Goals Health Health Benefit Health Care Costs Individual Interferon Type II Interleukin-10 Interleukin-6 Internet Intervention Knowledge Malignant Neoplasms Marital Status Measures Mediating Mediator of activation protein Medical Monitor Odds Ratio Online Systems Outcome Participant Patient Self-Report Personal Satisfaction Physical Function Physical activity Positioning Attribute Public Health Quality of life Quality-Adjusted Life Years Race Randomized Controlled Trials Recommendation Research Research Personnel Rural Rural Minority Sampling Second Primary Cancers Self Efficacy Site Societies Subgroup Supervision Survivors Technology Telomerase Testing Time Translating Treatment Efficacy Ursidae Family Waiting Lists Woman Work arm base behavior change biopsychosocial cancer diagnosis cancer therapy cancer type comorbidity cost cost effective cost effectiveness cost-effectiveness evaluation effectiveness measure efficacy testing exercise adherence exercise intensity exercise training expectation experience falls immunological status improved intervention cost intervention effect intrinsic motivation lean body mass meetings men mortality mortality risk post intervention primary outcome programs psychosocial randomized controlled design randomized trial rural dwellers secondary outcome survivorship symposium systemic inflammatory response theories treatment arm vigorous intensity waist circumference

项目摘要

Reaching Cancer Survivors with Distance-delivered Support for Physical Activity Behavior Change Cancer is the second leading cause of mortality in the U.S., resulting in over a half a million deaths each year. Furthermore, cancer survivors are more likely to suffer from second cancers, medical comorbidities, and reduced quality of life. Vulnerable cancer survivors (e.g., older, rural residents, underserved) bear a disproportionate burden of suffering after a cancer diagnosis related to greater mortality and poorer health and well-being. Exercise is an important aspect of survivorship care that can reduce this burden of suffering. However, the majority of cancer survivors do not engage in regular exercise, and behavior change interventions aimed at increasing exercise behavior often fall short of achieving the recommended exercise amount of ≥ 150 weekly minutes of moderate-to-vigorous intensity exercise. Moreover, such interventions are rarely tested for cost-effectiveness or translated into broader use. This proposal addresses this research gap by adapting the BEAT Cancer intervention, proven to be efficacious in significantly improving the odds of meeting exercise recommendations in cancer survivors, to web-based delivery that will increase its dissemination and implementation (D&I) potential. Core intervention components (i.e., elements responsible for intervention efficacy) identified during efficacy testing will also be adapted to improve acceptability among diverse cancer survivors (e.g., older, rural residents, African-Americans). The adapted intervention will be called Reaching out for Exercise Adherence to improve Cancer survivors' Health (REACH). The 6-month REACH intervention will then be tested in 326 survivors of a variety of cancers and in whom significant proportions will be older, rural, and minority. Investigators will employ a 2-arm randomized controlled design in which survivors will be assigned with equal allocation to receive REACH or wait-list control. Our primary aim will be to determine between-arm differences with regard to meeting current exercise recommendations (≥ 150 weekly minutes of ≥ moderate intensity physical activity) measured by accelerometer. Our secondary aims will include REACH's effects on self-reported physical activity and on anthropometrics (e.g., waist circumference), lean body mass, physical function, quality of life, and biomarkers (i.e., telomerase [marker of successful aging], IFNγ [immune status], and high sensitivity CRP, IL-6, and IL-10 [systemic inflammation]). Intervention cost- effectiveness will also be assessed. This proposal is critical to improving the D&I potential and public health impact of the core intervention components identified in an efficacious exercise behavior change program for cancer survivors. Increasing access to efficacious exercise behavior change interventions is critical to addressing the significant mortality, comorbidity, and psychosocial burden experienced by millions of cancer survivors each year.

通过远程支持帮助癌症幸存者改变身体活动行为