Quantitative and Molecular Characterization of HIV Persistence and Rebound in Early and Very-Early ART Treated Children

早期和极早期 ART 治疗儿童中 HIV 持续性和反弹的定量和分子特征

• 批准号: 10246902
• 负责人: Deborah Persaud
• 金额: $ 28.31万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-11 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10246902
• 关键词: Address; Adolescent; Adult; Aftercare; Age-Months; Anatomy; Biology; Cells; Child; Childhood; Clinical Research; Clinical Trials; DNA; Data; Development; Disease remission; Early treatment; Evolution; Fostering; Funding; Goals; Growth; HIV; HIV-1; Hour; Immune system; Impairment; Individual; Infant; Infection; Interruption; Kinetics; Knowledge; Life; Lymphoid; Measurement; Mission; Mississippi; Modeling; Molecular; Pathogenesis; Patients; Perinatal; Perinatal Infection; Peripheral Blood Mononuclear Cell; Relapse; Reporting; Research; Research Priority; Rest; Rhesus; SIV; Sampling; Sampling Studies; T-Cell Development; Therapeutic; Time; Tissues; United States National Institutes of Health; Viral; Viral Genome; Viral reservoir; Virus Latency; antiretroviral therapy; direct application; immune activation; immune reconstitution; infancy; infant infection; latent HIV reservoir; mathematical model; memory CD4 T lymphocyte; neutralizing antibody; pediatric human immunodeficiency virus; peripheral blood; reactivation from latency; viral rebound; virology; young adult

Project Summary The overarching goal of this proposal is to better understand the dynamics of HIV-1 persistence in perinatal infection with very early treatment (VET) within 48 hours of life, early treatment by 2-3 months of age combined with long-term suppression, and when initial ART is combined with broadly neutralizing antibodies, to facilitate viral remission. Eliminating the resting memory CD4+ T cell latent HIV-1 reservoir is the major challenge for eradicating HIV-1 from treated individuals. VET and early treatment of perinatal infection leads to a dramatic reduction in HIV-1 reservoir size that may enable sustained HIV-1 remission, but requires additional studies including mathematical modelling of reservoir dynamics. The proposed project will address a critical barrier to assessing HIV remission and cure studies in perinatally infected children and adolescents, with direct application to the rapidly evolving and exciting field of HIV cure. The studies have direct relevance to the research mission of the National Institutes of Health where finding ways to achieve HIV-1 viral remission or cure is a top research priority.

项目总结