Pathology and Biorepository Core (Core B)

摘要：病理学和生物库核心(核心B) MD Anderson癌症中心脑癌翻译研究的基本组成部分 孢子是涉及人体组织和血液样本的有针对性的翻译研究，允许 靶区和正常组织生物学调查及靶区和非靶区治疗效果评价 正常组织和特定的相关生物标记物的调节。病理学与生物信息库的核心 收集、处理和维护患者的人体组织样本，并将这些组织和 组织来源的原代胶质瘤干细胞(GSC)，以孢子研究。它一直是一种有效的资源 现有的孢子项目，严重依赖于组织，并将继续在 拟议中的孢子项目将继续推进。 病理学和生物库核心的具体目标如下： 目标1：组织银行。维护和加强现有的胶质瘤组织储存库，即胶质瘤干细胞(GSC) 来自MDACC患者的品系和患者匹配的血液样本。 目标2：资源分配。向孢子调查员提供胶质瘤组织、GSC和匹配的血液 促进基础研究、翻译研究和临床前研究。 目标3：病理学专业知识和基本服务。为组织病理学、 人体组织样本以及所产生的样本的免疫组织化学和分子特征 从动物模型到孢子调查过程。 目标4：综合数据基础。支持全面、集成的数据库，将详细的临床、 病理和放射学数据与生物储存库中的患者来源的组织资源。 目标5：孢子间合作。通过共享组织资源促进孢子间的合作。

SUMMARY: PATHOLOGY AND BIOREPOSITORY CORE (CORE B) A fundamental component of the translational research of the MD Anderson Cancer Center Brain Cancer SPORE is conduct of focused translational research involving human tissue and blood specimens, allowing investigation of the biology of target and normal tissues, and evaluation of treatment effects on both target and normal tissue and on modulation of specific, relevant biomarkers. The Pathology and Biorepository Core collects, processes and maintains human tissue specimens from patients and will disperse these tissues and tissue-derived primary glioma stem cell (GSC) to SPORE investigators. It has been an effective resource for the existing SPORE projects, which are heavily tissue-dependent and will continue to serve this function in the proposed SPORE Projects going forward. The specific aims of the Pathology and Biorepository Core are these: Aim 1: Tissue banking. Maintain and enhance the existing repository of glioma tissue, glioma stem cell (GSC) lines, and patient-matched blood specimens, derived from MDACC patients. Aim 2: Resource distribution. Provide glioma tissue, GSCs, and matched blood to SPORE investigators to facilitate basic, translational, and preclinical investigations. Aim 3: Pathology expertise and essential services. Provide comprehensive support for the histopathological, immunohistochemical, and molecular characterization of human tissue specimens as well as samples generated from animal models through the course of SPORE investigations. Aim 4: Integrated data basing. Support a comprehensive, integrated database linking detailed clinical, pathological, and radiographic data with patient-derived tissue resources in the biorepository. Aim 5: Inter-SPORE collaboration. Facilitate inter-SPORE collaborations through sharing of tissue resources.