MOLECULAR ONCOLOGY TRAINING GRANT

摘要 分子肿瘤学是一个快速变化的领域，在我们对肿瘤的理解方面取得了显著的新进展 肿瘤细胞的基础生物学及其与微环境的相互作用。这导致了越来越多的 肿瘤新药批准的数量，大多数针对信号的特定组件 小路。对基础癌症生物学家的现代培训需要广泛的技能和知识 纪律。这是华盛顿大学分子学院的第二次竞争性续签申请 肿瘤学培训计划，自2006年以来一直由NCI的T32奖项资助。它提供了 为1名博士后和4名博士后科学家提供津贴，目前的申请要求为 下一期的受训人数相同。这笔资金已经并将继续得到以下补充 西特曼癌症中心，该中心为另外6名博士前科学家提供津贴。每位实习生 参加该项目2年。到目前为止，该项目已培养了66名博士后学生和22名博士后 博士后研究员，几乎所有人都在继续他们的科学研究生涯。资金是 仅限于拥有博士学位的学员或获得博士学位的学员，不包括拥有MD或MD-PhD或其他 学位，或目前正在攻读这类研究生课程。因此，当前的计划填补了一个关键和重要的 该机构的教育角色不与其他培训计划重叠。该计划包括34个 多个不同部门的教职员工，在以下领域拥有大量研究资金和经验 指导学生和研究员，他们专注于了解实体肿瘤的分子基础和 血液系统恶性肿瘤的发生和发展。学员参加一年一度的授课课程 每年春季和期刊俱乐部每个秋季学期，每年一次的静修和研究进展会议 一年到头。学员还参加了临床和转化科学指导计划一 秋季学期每个月的一天。当前应用程序中的新功能是生物信息学训练营，以及 关于成像和药物发现的午餐研讨会系列，以及专注于 在我们癌症中心的集水区有需要。

ABSTRACT Molecular Oncology is a rapidly changing field, with remarkable new advances in our understanding of the basic biology of tumor cells and their interaction with the microenvironment. This has led to an increasing number of new oncology drug approvals, with the majority targeting specific components of signaling pathways. Modern training for basic cancer biologists requires diverse skills and knowledge in a wide range of disciplines. This is the second competitive renewal application of the Washington University Molecular Oncology Training Program, which has been funded by a T32 award from the NCI since 2006. It provides stipends for 1 predoctoral and 4 postdoctoral scientists, and the current application requests funds for the same number of trainees in the next period. This funding has been, and will continue to be supplemented by the Siteman Cancer Center, which provides stipends for 6 additional predoctoral scientists. Each trainee participates in the program for 2 years. Thus far, the program has trained 66 predoctoral students and 22 postdoctoral fellows, almost all of whom have continued their careers in scientific research. Funding is restricted to trainees with a PhD or those obtaining a PhD, and excludes those with MDs or MD-PhD or other degrees, or currently in such graduate programs. Thus, this current program fills a critical and important educational role for this institution that does not overlap with other training programs. The program includes 34 faculty members in many different departments who have substantial research funding and experience in mentoring students and fellows, who are focused on understanding the molecular basis of solid tumor and hematopoietic malignancy development and progression. Trainees participate in an annual didactic course each spring and journal clubs each fall semester, an annual retreat, and research-in-progress meetings throughout the year. Trainees also participate in a Clinical and Translational Science Mentoring Program one day each month in the fall semester. New in the current application are a bioinformatics boot camp, and luncheon seminar series in imaging and drug discovery, as well as a grant writing program focused on specific needs in our cancer's center's catchment area.